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Browse SMARCE1

Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus
Domain PF00505 HMG (high mobility group) box
Function

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells.

> Gene Ontology
 
Biological Process GO:0006333 chromatin assembly or disassembly
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0031498 chromatin disassembly
GO:0032984 macromolecular complex disassembly
GO:0032986 protein-DNA complex disassembly
GO:0034728 nucleosome organization
GO:0043044 ATP-dependent chromatin remodeling
GO:0043241 protein complex disassembly
GO:0071824 protein-DNA complex subunit organization
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001158 enhancer sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0003682 chromatin binding
GO:0003713 transcription coactivator activity
GO:0008080 N-acetyltransferase activity
GO:0016407 acetyltransferase activity
GO:0016410 N-acyltransferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0016922 ligand-dependent nuclear receptor binding
GO:0031490 chromatin DNA binding
GO:0031491 nucleosome binding
GO:0031492 nucleosomal DNA binding
GO:0035326 enhancer binding
GO:0043566 structure-specific DNA binding
GO:0047485 protein N-terminus binding
Cellular Component GO:0000785 chromatin
GO:0000790 nuclear chromatin
GO:0016514 SWI/SNF complex
GO:0017053 transcriptional repressor complex
GO:0044454 nuclear chromosome part
GO:0070603 SWI/SNF superfamily-type complex
GO:0071564 npBAF complex
GO:0071565 nBAF complex
GO:0090544 BAF-type complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-3247509: Chromatin modifying enzymes
R-HSA-4839726: Chromatin organization
R-HSA-3214858: RMTs methylate histone arginines
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SMARCE1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SMARCE1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.15; FDR: 0.02150 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.86; FDR: 0.007 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SMARCE1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0530.781
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.190.94
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0540.978
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2580.445
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.020.992
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6130.807
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0460.909
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0850.965
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0460.983
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2090.911
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3180.91
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0680.3
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SMARCE1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SMARCE1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SMARCE1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SMARCE1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SMARCE1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SMARCE1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SMARCE1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSMARCE1
NameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Aliases BAF57; BRG1-associated factor 57; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e ......
Chromosomal Location17q21.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SMARCE1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SMARCE1.
ID Name Drug Type Targets #Targets
DB12695Phenethyl IsothiocyanateSmall MoleculeACTA2, ACTB, ATP5B, ATP5I, ATP5L, CYB5B, DIABLO, FBXO41, HNRNPF, H ......45