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Browse SLC34A1

Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Multi-pass membrane protein
Domain PF02690 Na+/Pi-cotransporter
Function

Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001655 urogenital system development
GO:0001822 kidney development
GO:0006066 alcohol metabolic process
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0006820 anion transport
GO:0007584 response to nutrient
GO:0009100 glycoprotein metabolic process
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010288 response to lead ion
GO:0010966 regulation of phosphate transport
GO:0015672 monovalent inorganic cation transport
GO:0015698 inorganic anion transport
GO:0016137 glycoside metabolic process
GO:0019751 polyol metabolic process
GO:0030002 cellular anion homeostasis
GO:0030643 cellular phosphate ion homeostasis
GO:0030647 aminoglycoside antibiotic metabolic process
GO:0031667 response to nutrient levels
GO:0032026 response to magnesium ion
GO:0032355 response to estradiol
GO:0033189 response to vitamin A
GO:0033273 response to vitamin
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035435 phosphate ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0035864 response to potassium ion
GO:0042391 regulation of membrane potential
GO:0042430 indole-containing compound metabolic process
GO:0042431 indole metabolic process
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042493 response to drug
GO:0043270 positive regulation of ion transport
GO:0043279 response to alkaloid
GO:0043434 response to peptide hormone
GO:0044070 regulation of anion transport
GO:0044341 sodium-dependent phosphate transport
GO:0045838 positive regulation of membrane potential
GO:0046686 response to cadmium ion
GO:0046689 response to mercury ion
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0055062 phosphate ion homeostasis
GO:0055081 anion homeostasis
GO:0060416 response to growth hormone
GO:0071107 response to parathyroid hormone
GO:0071241 cellular response to inorganic substance
GO:0071248 cellular response to metal ion
GO:0071312 cellular response to alkaloid
GO:0071374 cellular response to parathyroid hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0072001 renal system development
GO:0072350 tricarboxylic acid metabolic process
GO:0072502 cellular trivalent inorganic anion homeostasis
GO:0072506 trivalent inorganic anion homeostasis
GO:0072733 response to staurosporine
GO:0072734 cellular response to staurosporine
GO:0097066 response to thyroid hormone
GO:0097187 dentinogenesis
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1901128 gentamycin metabolic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901652 response to peptide
GO:1901657 glycosyl compound metabolic process
GO:1901684 arsenate ion transmembrane transport
GO:1903793 positive regulation of anion transport
GO:1903795 regulation of inorganic anion transmembrane transport
GO:1903797 positive regulation of inorganic anion transmembrane transport
GO:1903959 regulation of anion transmembrane transport
GO:1903961 positive regulation of anion transmembrane transport
GO:1990267 response to transition metal nanoparticle
GO:2000118 regulation of sodium-dependent phosphate transport
GO:2000120 positive regulation of sodium-dependent phosphate transport
GO:2000185 regulation of phosphate transmembrane transport
GO:2000187 positive regulation of phosphate transmembrane transport
Molecular Function GO:0005315 inorganic phosphate transmembrane transporter activity
GO:0005436 sodium:phosphate symporter activity
GO:0008509 anion transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015114 phosphate ion transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015296 anion:cation symporter activity
GO:0015321 sodium-dependent phosphate transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0046873 metal ion transmembrane transporter activity
GO:1901677 phosphate transmembrane transporter activity
Cellular Component GO:0005903 brush border
GO:0016324 apical plasma membrane
GO:0031253 cell projection membrane
GO:0031526 brush border membrane
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-427652: Sodium-coupled phosphate cotransporters
R-HSA-5683826: Surfactant metabolism
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-427589: Type II Na+/Pi cotransporters
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC34A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC34A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC34A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.7190.449
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3640.812
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472.0730.193
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5410.22
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5410.407
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.730.00598
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC34A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC34A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC34A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC34A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC34A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC34A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC34A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC34A1
Namesolute carrier family 34 (type II sodium/phosphate cotransporter), member 1
Aliases NAPI-3; NPTIIa; SLC11; sodium/phosphate co-transporter; Na+-phosphate cotransporter type II; NPT2; solute ca ......
Chromosomal Location5q35.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC34A1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.