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Browse SLC24A3

Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF01699 Sodium/calcium exchanger protein
Function

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).

> Gene Ontology
 
Biological Process GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0015672 monovalent inorganic cation transport
GO:0035725 sodium ion transmembrane transport
GO:0055074 calcium ion homeostasis
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
Molecular Function GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0008273 calcium, potassium:sodium antiporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0015298 solute:cation antiporter activity
GO:0015368 calcium:cation antiporter activity
GO:0015491 cation:cation antiporter activity
GO:0022803 passive transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0022821 potassium ion antiporter activity
GO:0022838 substrate-specific channel activity
GO:0030955 potassium ion binding
GO:0031402 sodium ion binding
GO:0031420 alkali metal ion binding
GO:0046873 metal ion transmembrane transporter activity
GO:0072509 divalent inorganic cation transmembrane transporter activity
GO:0099516 ion antiporter activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-425561: Sodium/Calcium exchangers
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC24A3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC24A3 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC24A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0450.923
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4040.594
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2210.731
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.8390.0451
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7890.651
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.9050.662
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4030.538
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.40.69
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.1970.239
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2490.731
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7430.429
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5870.00186
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC24A3 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.11.49.70.0589
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.11.79.40.0895
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC24A3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC24A3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC24A3.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC24A3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC24A3 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC24A3 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC24A3
Namesolute carrier family 24 (sodium/potassium/calcium exchanger), member 3
Aliases NCKX3; Na(+)/K(+)/Ca(2+)-exchange protein 3; sodium calcium exchanger; solute carrier family 24 member 3; So ......
Chromosomal Location20p13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC24A3 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.