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Browse SLC12A1

Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Multi-pass membrane protein.
Domain PF00324 Amino acid permease
PF08403 Amino acid permease N-terminal
PF03522 Solute carrier family 12
Function

Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

> Gene Ontology
 
Biological Process GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0015672 monovalent inorganic cation transport
GO:0015698 inorganic anion transport
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1902476 chloride transmembrane transport
Molecular Function GO:0008509 anion transmembrane transporter activity
GO:0008511 sodium:potassium:chloride symporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015296 anion:cation symporter activity
GO:0015377 cation:chloride symporter activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
Cellular Component GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-426117: Cation-coupled Chloride cotransporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC12A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC12A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC12A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.6390.404
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1570.923
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.2350.472
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0280.969
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.8940.5
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.0110.49
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0890.819
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3420.563
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.9370.0451
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC12A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC12A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC12A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC12A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC12A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC12A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC12A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC12A1
Namesolute carrier family 12 (sodium/potassium/chloride transporter), member 1
Aliases NKCC2; BSC1; NKCC2A variant A; Na-K-2Cl cotransporter; bumetanide-sensitive sodium-(potassium)-chloride cotr ......
Chromosomal Location15q15-q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC12A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC12A1.
ID Name Drug Type Targets #Targets
DB00214TorasemideSmall MoleculeSLC12A11
DB00232MethyclothiazideSmall MoleculeCA1, CA2, CA4, SLC12A14
DB00310ChlorthalidoneSmall MoleculeSLC12A11
DB00534ChlormerodrinSmall MoleculeALDH5A1, SLC12A12
DB00695FurosemideSmall MoleculeCA2, SLC12A12
DB00761Potassium ChlorideSmall MoleculeSLC12A1, SLC12A2, SLC12A4, SLC12A5, SLC12A6, SLC12A76
DB00774HydroflumethiazideSmall MoleculeATP1A1, CA1, CA12, CA2, CA4, CA9, KCNMA1, SLC12A18
DB00887BumetanideSmall MoleculeCFTR, SLC12A1, SLC12A2, SLC12A4, SLC12A55
DB00903Etacrynic acidSmall MoleculeATP1A1, GSTP1, LEF1, SLC12A14
DB01021TrichlormethiazideSmall MoleculeATP1A1, CA1, CA2, CA4, SLC12A15
DB01325QuinethazoneSmall MoleculeCA1, CA2, SLC12A1, SLC12A2, SLC12A35
DB02925PiretanideSmall MoleculeSLC12A11