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Browse SLC6A1

Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Note=Localized at the plasma membrane and in a subset of intracellular vesicles. Localized at the presynaptic terminals of interneurons (By similarity).
Domain PF00209 Sodium
Function

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

> Gene Ontology
 
Biological Process GO:0006820 anion transport
GO:0006836 neurotransmitter transport
GO:0006865 amino acid transport
GO:0007270 neuron-neuron synaptic transmission
GO:0007611 learning or memory
GO:0007612 learning
GO:0009636 response to toxic substance
GO:0009743 response to carbohydrate
GO:0009744 response to sucrose
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010288 response to lead ion
GO:0014051 gamma-aminobutyric acid secretion
GO:0014052 regulation of gamma-aminobutyric acid secretion
GO:0014054 positive regulation of gamma-aminobutyric acid secretion
GO:0014074 response to purine-containing compound
GO:0015711 organic anion transport
GO:0015800 acidic amino acid transport
GO:0015812 gamma-aminobutyric acid transport
GO:0015849 organic acid transport
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032355 response to estradiol
GO:0034285 response to disaccharide
GO:0042220 response to cocaine
GO:0043270 positive regulation of ion transport
GO:0043279 response to alkaloid
GO:0044070 regulation of anion transport
GO:0044708 single-organism behavior
GO:0046717 acid secretion
GO:0046942 carboxylic acid transport
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050890 cognition
GO:0051047 positive regulation of secretion
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051592 response to calcium ion
GO:0051932 synaptic transmission, GABAergic
GO:0051939 gamma-aminobutyric acid import
GO:1903793 positive regulation of anion transport
Molecular Function GO:0005283 sodium:amino acid symporter activity
GO:0005326 neurotransmitter transporter activity
GO:0005328 neurotransmitter:sodium symporter activity
GO:0005332 gamma-aminobutyric acid:sodium symporter activity
GO:0005342 organic acid transmembrane transporter activity
GO:0005343 organic acid:sodium symporter activity
GO:0005416 cation:amino acid symporter activity
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015185 gamma-aminobutyric acid transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015370 solute:sodium symporter activity
GO:0022804 active transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component GO:0030424 axon
> KEGG and Reactome Pathway
 
KEGG hsa04727 GABAergic synapse
Reactome R-HSA-425428: Amine compound SLC transporters
R-HSA-888590: GABA synthesis, release, reuptake and degradation
R-HSA-442660: Na+/Cl- dependent neurotransmitter transporters
R-HSA-112316: Neuronal System
R-HSA-112310: Neurotransmitter Release Cycle
R-HSA-888593: Reuptake of GABA
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-112315: Transmission across Chemical Synapses
R-HSA-425366: Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC6A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC6A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC6A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1280.739
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4980.431
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5920.285
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.8180.144
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3470.28
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1610.901
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0320.961
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0730.94
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0570.956
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.140.876
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.9550.389
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6169.61e-05
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC6A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.517.6-8.10.64
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.516.7-4.21
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.718.2-10.50.576
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC6A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC6A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC6A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC6A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC6A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC6A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC6A1
Namesolute carrier family 6 (neurotransmitter transporter), member 1
Aliases GAT1; GABATR; GABATHG; GABA transporter 1; solute carrier family 6 (neurotransmitter transporter, GABA), mem ......
Chromosomal Location3p25.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC6A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting SLC6A1.
ID Name Drug Type Targets #Targets
DB00906TiagabineSmall MoleculeSLC6A11
DB08848GuvacineSmall MoleculeSLC6A1, SLC6A11, SLC6A12, SLC6A134