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Browse SLC5A8

Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Multi-pass membrane protein Note=Expressed at the apical membrane of normal tall thyrocytes and of colonic epithelial cells.
Domain PF00474 Sodium
Function

Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), lactate, mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1. Catalyzes passive carrier mediated diffusion of iodide. Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane. May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract. Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines. May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons.

> Gene Ontology
 
Biological Process GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0015672 monovalent inorganic cation transport
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0046942 carboxylic acid transport
Molecular Function GO:0005342 organic acid transmembrane transporter activity
GO:0008028 monocarboxylic acid transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0022803 passive transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425374: Amino acid and oligopeptide SLC transporters
R-HSA-1430728: Metabolism
R-HSA-196854: Metabolism of vitamins and cofactors
R-HSA-196849: Metabolism of water-soluble vitamins and cofactors
R-HSA-197264: Nicotinamide salvaging
R-HSA-196807: Nicotinate metabolism
R-HSA-428643: Organic anion transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC5A8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SLC5A8 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25984582Colon CarcinomaInhibit immunity (T cell function)Slc5a8-null DCs do not induce IDO1 and Aldh1A2 and do not generate Tregs or suppress IFN-γ-producing T-cells in response to butyrate.
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC5A8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC5A8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4990.486
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7990.494
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1370.91
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.4580.562
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.0920.496
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-2.0040.299
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2580.821
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2160.41
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0450.873
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC5A8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.48.2-0.81
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.48.5-1.11
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211723.85.917.90.197
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC5A8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC5A8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC5A8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC5A8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC5A8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC5A8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC5A8
Namesolute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
Aliases AIT; solute carrier family 5 (iodide transporter), member 8; SMCT; SMCT1; apical iodide transporter; electro ......
Chromosomal Location12q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC5A8 collected from DrugBank database.
> Drugs from DrugBank database
 

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