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Browse SLC4A7

Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Basolateral cell membrane; Multi-pass membrane protein. Apical cell membrane Multi-pass membrane protein Cell projection, stereocilium Note=Also described at the apical cell membrane. Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells (By similarity).
Domain PF07565 Band 3 cytoplasmic domain
PF00955 HCO3- transporter family
Function

Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity.

> Gene Ontology
 
Biological Process GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002066 columnar/cuboidal epithelial cell development
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0006885 regulation of pH
GO:0007423 sensory organ development
GO:0008544 epidermis development
GO:0009913 epidermal cell differentiation
GO:0015672 monovalent inorganic cation transport
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0015711 organic anion transport
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030641 regulation of cellular pH
GO:0035315 hair cell differentiation
GO:0035725 sodium ion transmembrane transport
GO:0042490 mechanoreceptor differentiation
GO:0042491 auditory receptor cell differentiation
GO:0043583 ear development
GO:0048839 inner ear development
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0060113 inner ear receptor cell differentiation
GO:0060117 auditory receptor cell development
GO:0060119 inner ear receptor cell development
GO:0060563 neuroepithelial cell differentiation
GO:0098656 anion transmembrane transport
Molecular Function GO:0005452 inorganic anion exchanger activity
GO:0008509 anion transmembrane transporter activity
GO:0008510 sodium:bicarbonate symporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015077 monovalent inorganic cation transmembrane transporter activity
GO:0015081 sodium ion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015291 secondary active transmembrane transporter activity
GO:0015293 symporter activity
GO:0015294 solute:cation symporter activity
GO:0015296 anion:cation symporter activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0046873 metal ion transmembrane transporter activity
Cellular Component GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0045177 apical part of cell
GO:0098858 actin-based cell projection
GO:0098862 cluster of actin-based cell projections
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-425381: Bicarbonate transporters
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-425393: Transport of inorganic cations/anions and amino acids/oligopeptides
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SLC4A7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SLC4A7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SLC4A7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.3870.259
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3990.77
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3760.707
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.370.203
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2940.896
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.4680.868
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0260.949
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1470.93
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1340.942
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.3150.714
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.3140.792
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0850.279
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SLC4A7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.33.71.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SLC4A7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SLC4A7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SLC4A7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SLC4A7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SLC4A7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SLC4A7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSLC4A7
Namesolute carrier family 4, sodium bicarbonate cotransporter, member 7
Aliases SBC2; SLC4A6; NBCN1; bicarbonate transporter; electroneutral Na/HCO(3) cotransporter; sodium bicarbonate cot ......
Chromosomal Location3p24.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SLC4A7 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.