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Browse SELPLG

Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Membrane; Single-pass type I membrane protein.
Domain -
Function

A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. ; FUNCTION: (Microbial infection) Acts as a receptor for enterovirus 71.

> Gene Ontology
 
Biological Process GO:0019058 viral life cycle
GO:0030260 entry into host cell
GO:0044409 entry into host
GO:0045123 cellular extravasation
GO:0046718 viral entry into host cell
GO:0050900 leukocyte migration
GO:0050902 leukocyte adhesive activation
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0070741 response to interleukin-6
GO:0071354 cellular response to interleukin-6
Molecular Function GO:0001618 virus receptor activity
Cellular Component GO:0001931 uropod
GO:0031254 cell trailing edge
> KEGG and Reactome Pathway
 
KEGG hsa04514 Cell adhesion molecules (CAMs)
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SELPLG and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SELPLG and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27192578MelanomaInhibit immunity (T cell function)In models of melanoma cancer in which T cell dysfunction occurs, PSGL-1 deficiency led to PD-1 downregulation, improved T cell responses, and tumor control.
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SELPLG in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SELPLG in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0870.818
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.110.944
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2320.847
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2180.725
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6570.671
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3330.536
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2780.578
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.6260.632
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1730.91
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.4920.316
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4020.55
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0920.605
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SELPLG. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SELPLG. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SELPLG.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SELPLG. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SELPLG expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SELPLG and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSELPLG
Nameselectin P ligand
Aliases PSGL-1; CD162; CLA; PSGL1; cutaneous lymphocyte-associated associated antigen; CD antigen CD162; P-selectin ......
Chromosomal Location12q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SELPLG collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.