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Browse SCRIB

Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Peripheral membrane protein. Cell junction, adherens junction. Cell projection, lamellipodium. Cytoplasm. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity. Localizes to neuronal post- and pre-synaptic regions.
Domain PF13855 Leucine rich repeat
PF00595 PDZ domain (Also known as DHR or GLGF)
Function

Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0001838 embryonic epithelial tube formation
GO:0001841 neural tube formation
GO:0001843 neural tube closure
GO:0001881 receptor recycling
GO:0001919 regulation of receptor recycling
GO:0001921 positive regulation of receptor recycling
GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002066 columnar/cuboidal epithelial cell development
GO:0002093 auditory receptor cell morphogenesis
GO:0006836 neurotransmitter transport
GO:0006887 exocytosis
GO:0006898 receptor-mediated endocytosis
GO:0006903 vesicle targeting
GO:0007163 establishment or maintenance of cell polarity
GO:0007269 neurotransmitter secretion
GO:0007346 regulation of mitotic cell cycle
GO:0007423 sensory organ development
GO:0008105 asymmetric protein localization
GO:0008347 glial cell migration
GO:0008544 epidermis development
GO:0009913 epidermal cell differentiation
GO:0014020 primary neural tube formation
GO:0016079 synaptic vesicle exocytosis
GO:0016080 synaptic vesicle targeting
GO:0016331 morphogenesis of embryonic epithelium
GO:0017156 calcium ion regulated exocytosis
GO:0021548 pons development
GO:0021747 cochlear nucleus development
GO:0021915 neural tube development
GO:0022037 metencephalon development
GO:0022612 gland morphogenesis
GO:0023061 signal release
GO:0030010 establishment of cell polarity
GO:0030879 mammary gland development
GO:0030902 hindbrain development
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0035089 establishment of apical/basal cell polarity
GO:0035148 tube formation
GO:0035239 tube morphogenesis
GO:0035315 hair cell differentiation
GO:0036465 synaptic vesicle recycling
GO:0042063 gliogenesis
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042490 mechanoreceptor differentiation
GO:0042491 auditory receptor cell differentiation
GO:0043112 receptor metabolic process
GO:0043583 ear development
GO:0043615 astrocyte cell migration
GO:0045055 regulated exocytosis
GO:0045786 negative regulation of cell cycle
GO:0045930 negative regulation of mitotic cell cycle
GO:0048488 synaptic vesicle endocytosis
GO:0048489 synaptic vesicle transport
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048732 gland development
GO:0048839 inner ear development
GO:0048857 neural nucleus development
GO:0050918 positive chemotaxis
GO:0051640 organelle localization
GO:0051648 vesicle localization
GO:0051650 establishment of vesicle localization
GO:0051656 establishment of organelle localization
GO:0060088 auditory receptor cell stereocilium organization
GO:0060113 inner ear receptor cell differentiation
GO:0060117 auditory receptor cell development
GO:0060119 inner ear receptor cell development
GO:0060122 inner ear receptor stereocilium organization
GO:0060443 mammary gland morphogenesis
GO:0060561 apoptotic process involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060563 neuroepithelial cell differentiation
GO:0060603 mammary gland duct morphogenesis
GO:0060606 tube closure
GO:0061162 establishment of monopolar cell polarity
GO:0061180 mammary gland epithelium development
GO:0061245 establishment or maintenance of bipolar cell polarity
GO:0061339 establishment or maintenance of monopolar cell polarity
GO:0071896 protein localization to adherens junction
GO:0072175 epithelial tube formation
GO:0072583 clathrin-dependent endocytosis
GO:0090596 sensory organ morphogenesis
GO:0090630 activation of GTPase activity
GO:0097479 synaptic vesicle localization
GO:0097480 establishment of synaptic vesicle localization
GO:0099003 vesicle-mediated transport in synapse
GO:0099504 synaptic vesicle cycle
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1902414 protein localization to cell junction
GO:1902742 apoptotic process involved in development
Molecular Function GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005913 cell-cell adherens junction
GO:0016323 basolateral plasma membrane
GO:0030027 lamellipodium
GO:0031252 cell leading edge
GO:0034750 Scrib-APC-beta-catenin complex
GO:0035748 myelin sheath abaxonal region
GO:0042734 presynaptic membrane
GO:0043209 myelin sheath
GO:0045211 postsynaptic membrane
GO:0097060 synaptic membrane
GO:0098793 presynapse
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG hsa04390 Hippo signaling pathway
hsa04530 Tight junction
Reactome R-HSA-4608870: Asymmetric localization of PCP proteins
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-4086400: PCP/CE pathway
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between SCRIB and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between SCRIB and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
24276238Non-Small Cell Lung CarcinomaInhibit immunityScrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo. A survey of genomic databases reveals deregulation of SCRIB in human lung cancer and we show that Scrib(+/-) mutant mice develop lung cancer by 540 days with a penetrance of 43%. We show that loss of Scrib and activated oncogenic KRas cooperate in vivo, resulting in more aggressive lung tumors, likely due to a synergistic elevation in RAS-MAPK signaling.
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of SCRIB in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.14; FDR: 0.015 Resistant to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of SCRIB in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1460.617
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.6150.778
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.190.912
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.5170.238
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8740.753
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.0680.985
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2350.568
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0450.976
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5220.762
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2590.854
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.0950.963
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1150.253
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of SCRIB in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.74.1-0.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59022.2-22.20.505
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 6116.7016.71
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of SCRIB. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of SCRIB. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by SCRIB.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of SCRIB. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of SCRIB expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between SCRIB and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolSCRIB
Namescribbled planar cell polarity protein
Aliases KIAA0147; SCRB1; Vartul; scribbled homolog (Drosophila); CRIB1; SCRB11; scribbled homolog; Protein LAP4; hSc ......
Chromosomal Location8q24.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting SCRIB collected from DrugBank database.
> Drugs from DrugBank database
 

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