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Browse RPS19

Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Note=Located more specifically in the nucleoli.
Domain PF01090 Ribosomal protein S19e
Function

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

> Gene Ontology
 
Biological Process GO:0000028 ribosomal small subunit assembly
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0002262 myeloid cell homeostasis
GO:0002532 production of molecular mediator involved in inflammatory response
GO:0002536 respiratory burst involved in inflammatory response
GO:0002548 monocyte chemotaxis
GO:0002679 respiratory burst involved in defense response
GO:0002683 negative regulation of immune system process
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002699 positive regulation of immune effector process
GO:0006364 rRNA processing
GO:0006401 RNA catabolic process
GO:0006402 mRNA catabolic process
GO:0006413 translational initiation
GO:0006612 protein targeting to membrane
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006997 nucleus organization
GO:0007000 nucleolus organization
GO:0007219 Notch signaling pathway
GO:0009991 response to extracellular stimulus
GO:0016072 rRNA metabolic process
GO:0019058 viral life cycle
GO:0019080 viral gene expression
GO:0019083 viral transcription
GO:0019439 aromatic compound catabolic process
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0030099 myeloid cell differentiation
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0030595 leukocyte chemotaxis
GO:0031348 negative regulation of defense response
GO:0031349 positive regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0032103 positive regulation of response to external stimulus
GO:0034101 erythrocyte homeostasis
GO:0034470 ncRNA processing
GO:0034655 nucleobase-containing compound catabolic process
GO:0042254 ribosome biogenesis
GO:0042255 ribosome assembly
GO:0042274 ribosomal small subunit biogenesis
GO:0044033 multi-organism metabolic process
GO:0044270 cellular nitrogen compound catabolic process
GO:0045047 protein targeting to ER
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045730 respiratory burst
GO:0045824 negative regulation of innate immune response
GO:0046700 heterocycle catabolic process
GO:0048872 homeostasis of number of cells
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050900 leukocyte migration
GO:0051259 protein oligomerization
GO:0051262 protein tetramerization
GO:0051272 positive regulation of cellular component movement
GO:0060263 regulation of respiratory burst
GO:0060264 regulation of respiratory burst involved in inflammatory response
GO:0060265 positive regulation of respiratory burst involved in inflammatory response
GO:0060266 negative regulation of respiratory burst involved in inflammatory response
GO:0060267 positive regulation of respiratory burst
GO:0060268 negative regulation of respiratory burst
GO:0060326 cell chemotaxis
GO:0070972 protein localization to endoplasmic reticulum
GO:0071674 mononuclear cell migration
GO:0071826 ribonucleoprotein complex subunit organization
GO:0072599 establishment of protein localization to endoplasmic reticulum
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0097529 myeloid leukocyte migration
GO:1901361 organic cyclic compound catabolic process
Molecular Function GO:0003735 structural constituent of ribosome
GO:0017134 fibroblast growth factor binding
GO:0019838 growth factor binding
Cellular Component GO:0005840 ribosome
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030055 cell-substrate junction
GO:0044391 ribosomal subunit
GO:0044445 cytosolic part
> KEGG and Reactome Pathway
 
KEGG hsa03010 Ribosome
Reactome R-HSA-157279: 3' -UTR-mediated translational regulation
R-HSA-72662: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-HSA-72737: Cap-dependent Translation Initiation
R-HSA-1643685: Disease
R-HSA-156842: Eukaryotic Translation Elongation
R-HSA-72613: Eukaryotic Translation Initiation
R-HSA-72764: Eukaryotic Translation Termination
R-HSA-72689: Formation of a pool of free 40S subunits
R-HSA-72695: Formation of the ternary complex, and subsequently, the 43S complex
R-HSA-72706: GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-74160: Gene Expression
R-HSA-5663205: Infectious disease
R-HSA-168254: Influenza Infection
R-HSA-168255: Influenza Life Cycle
R-HSA-168273: Influenza Viral RNA Transcription and Replication
R-HSA-156827: L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-6791226: Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-392499: Metabolism of proteins
R-HSA-975957: Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
R-HSA-975956: Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-927802: Nonsense-Mediated Decay (NMD)
R-HSA-156902: Peptide chain elongation
R-HSA-72702: Ribosomal scanning and start codon recognition
R-HSA-1799339: SRP-dependent cotranslational protein targeting to membrane
R-HSA-2408522: Selenoamino acid metabolism
R-HSA-2408557: Selenocysteine synthesis
R-HSA-72766: Translation
R-HSA-72649: Translation initiation complex formation
R-HSA-192823: Viral mRNA Translation
R-HSA-72312: rRNA processing
R-HSA-8868773: rRNA processing in the nucleus and cytosol
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RPS19 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between RPS19 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
28228558Breast Carcinoma; Ovarian CarcinomaInhibit immunity (T cell function)RPS19 also induces the production of immunosuppressive cytokines, including TGF-β, by myeloid-derived suppressor cells in tumor-draining lymph nodes, leading to T cell responses skewed toward Th2 phenotypes.
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RPS19 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RPS19 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1650.669
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1630.974
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3980.915
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4350.284
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.540.84
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3040.929
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1190.844
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4060.876
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1520.959
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1040.977
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3120.956
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0210.805
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RPS19 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPS19. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPS19. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPS19.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPS19. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RPS19 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RPS19 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRPS19
Nameribosomal protein S19
Aliases S19; Diamond-Blackfan anemia; DBA1; 40S ribosomal protein S19
Chromosomal Location19q13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RPS19 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting RPS19.
ID Name Drug Type Targets #Targets
DB11638ArtenimolSmall MoleculeACTG1, ALB, ALDH7A1, ALDOA, ANXA2, ATP5A1, ATP5L, ATP5O, CAST, CCT ......79