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Browse RPS6KB1

Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell junction, synapse, synaptosome Mitochondrion outer membrane. Mitochondrion. Note=Colocalizes with URI1 at mitochondrion.; SUBCELLULAR LOCATION: Isoform Alpha I: Nucleus. Cytoplasm.; SUBCELLULAR LOCATION: Isoform Alpha II: Cytoplasm.
Domain PF00069 Protein kinase domain
PF00433 Protein kinase C terminal domain
Function

Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR (PubMed:11500364, PubMed:12801526, PubMed:14673156, PubMed:15071500, PubMed:15341740, PubMed:16286006, PubMed:17052453, PubMed:17053147, PubMed:17936702, PubMed:18952604, PubMed:19085255, PubMed:19720745, PubMed:19935711, PubMed:19995915, PubMed:23429703). Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition (PubMed:28178239).

> Gene Ontology
 
Biological Process GO:0000082 G1/S transition of mitotic cell cycle
GO:0001101 response to acid chemical
GO:0001662 behavioral fear response
GO:0002209 behavioral defense response
GO:0002237 response to molecule of bacterial origin
GO:0003009 skeletal muscle contraction
GO:0003012 muscle system process
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006446 regulation of translational initiation
GO:0006936 muscle contraction
GO:0006941 striated muscle contraction
GO:0007281 germ cell development
GO:0007346 regulation of mitotic cell cycle
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007568 aging
GO:0007584 response to nutrient
GO:0007611 learning or memory
GO:0007613 memory
GO:0007616 long-term memory
GO:0008286 insulin receptor signaling pathway
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0009612 response to mechanical stimulus
GO:0009636 response to toxic substance
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009991 response to extracellular stimulus
GO:0010608 posttranscriptional regulation of gene expression
GO:0010827 regulation of glucose transport
GO:0014706 striated muscle tissue development
GO:0014732 skeletal muscle atrophy
GO:0014812 muscle cell migration
GO:0014874 response to stimulus involved in regulation of muscle adaptation
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation
GO:0014888 striated muscle adaptation
GO:0014889 muscle atrophy
GO:0014891 striated muscle atrophy
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0014911 positive regulation of smooth muscle cell migration
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0016202 regulation of striated muscle tissue development
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030335 positive regulation of cell migration
GO:0031667 response to nutrient levels
GO:0031929 TOR signaling
GO:0031960 response to corticosteroid
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0033002 muscle cell proliferation
GO:0033555 multicellular organismal response to stress
GO:0033574 response to testosterone
GO:0033762 response to glucagon
GO:0034248 regulation of cellular amide metabolic process
GO:0034250 positive regulation of cellular amide metabolic process
GO:0034284 response to monosaccharide
GO:0034612 response to tumor necrosis factor
GO:0040017 positive regulation of locomotion
GO:0042493 response to drug
GO:0042596 fear response
GO:0043200 response to amino acid
GO:0043201 response to leucine
GO:0043434 response to peptide hormone
GO:0043491 protein kinase B signaling
GO:0043500 muscle adaptation
GO:0043501 skeletal muscle adaptation
GO:0043502 regulation of muscle adaptation
GO:0044057 regulation of system process
GO:0044708 single-organism behavior
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045471 response to ethanol
GO:0045727 positive regulation of translation
GO:0045787 positive regulation of cell cycle
GO:0045844 positive regulation of striated muscle tissue development
GO:0045927 positive regulation of growth
GO:0045931 positive regulation of mitotic cell cycle
GO:0045948 positive regulation of translational initiation
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048545 response to steroid hormone
GO:0048630 skeletal muscle tissue growth
GO:0048631 regulation of skeletal muscle tissue growth
GO:0048633 positive regulation of skeletal muscle tissue growth
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0050879 multicellular organismal movement
GO:0050881 musculoskeletal movement
GO:0050890 cognition
GO:0051272 positive regulation of cellular component movement
GO:0051384 response to glucocorticoid
GO:0051602 response to electrical stimulus
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0071375 cellular response to peptide hormone stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0090257 regulation of muscle system process
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097305 response to alcohol
GO:1900076 regulation of cellular response to insulin stimulus
GO:1900077 negative regulation of cellular response to insulin stimulus
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
GO:2000147 positive regulation of cell motility
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030165 PDZ domain binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0051721 protein phosphatase 2A binding
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031968 organelle outer membrane
> KEGG and Reactome Pathway
 
KEGG hsa04012 ErbB signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04350 TGF-beta signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04910 Insulin signaling pathway
Reactome R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-109704: PI3K Cascade
R-HSA-109703: PKB-mediated events
R-HSA-162582: Signal Transduction
R-HSA-74752: Signaling by Insulin receptor
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-165159: mTOR signalling
R-HSA-166208: mTORC1-mediated signalling
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RPS6KB1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RPS6KB1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 4.58; FDR: 0.011 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX STARS Score: 4.96; FDR: 0.009 Sensitive to T cell-mediated killing
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RPS6KB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.060.785
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2230.872
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.0610.95
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0240.915
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1360.941
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2280.924
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0370.912
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1120.943
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2010.909
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1740.894
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2510.897
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.050.253
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RPS6KB1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RPS6KB1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RPS6KB1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RPS6KB1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RPS6KB1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RPS6KB1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RPS6KB1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRPS6KB1
Nameribosomal protein S6 kinase, 70kDa, polypeptide 1
Aliases S6K1; p70(S6K)-alpha; PS6K; STK14A; ribosomal protein S6 kinase, 70kD, polypeptide 1; S6K; S6K-beta-1; p70 S ......
Chromosomal Location17q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RPS6KB1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.