TISIDB

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytosol Membrane
Domain	PF08737 Rgp1
Function	The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors.

> Gene Ontology [ TOP ]
Biological Process	GO:0007034 vacuolar transport GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0016197 endosomal transport GO:0016482 cytosolic transport GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0042147 retrograde transport, endosome to Golgi GO:0042176 regulation of protein catabolic process GO:0042177 negative regulation of protein catabolic process GO:1903362 regulation of cellular protein catabolic process GO:1903363 negative regulation of cellular protein catabolic process
Molecular Function	GO:0005085 guanyl-nucleotide exchange factor activity GO:0005088 Ras guanyl-nucleotide exchange factor activity GO:0017016 Ras GTPase binding GO:0017112 Rab guanyl-nucleotide exchange factor activity GO:0017137 Rab GTPase binding GO:0031267 small GTPase binding GO:0051020 GTPase binding
Cellular Component	GO:0005802 trans-Golgi network GO:0031984 organelle subcompartment GO:0032045 guanyl-nucleotide exchange factor complex GO:0032588 trans-Golgi network membrane GO:0034066 RIC1-RGP1 guanyl-nucleotide exchange factor complex GO:0098791 Golgi subcompartment

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-6811442: Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-6811438: Intra-Golgi traffic R-HSA-199991: Membrane Trafficking R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-6811440: Retrograde transport at the Trans-Golgi-Network R-HSA-5653656: Vesicle-mediated transport

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between RGP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of RGP1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	logFC: -2.09; FDR: 0.04630	Resistant to T cell-mediated killing
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.51	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of RGP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.473	0.0927
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.893	0.509
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.171	0.856
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.697	0.00946
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.571	0.784
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.86	0.755
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.221	0.416
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.24	0.791
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.246	0.795
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.212	0.847
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.939	0.525
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.019	0.758

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of RGP1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	7.1	0	7.1	0.452
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	10	0	10	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	1.4	-1.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	1.7	-1.7	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RGP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RGP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RGP1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RGP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of RGP1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between RGP1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	RGP1
Name	RGP1 homolog, RAB6A GEF complex partner 1
Aliases	KIAA0258; RGP1 retrograde golgi transport homolog (S. cerevisiae); RGP1 retrograde golgi transport homolog; ......
Chromosomal Location	9p13.3
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting RGP1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse RGP1