[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse RAC1

Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Lipid-anchor Cytoplasmic side Melanosome Cytoplasm Note=Inner surface of plasma membrane possibly with attachment requiring prenylation of the C-terminal cysteine (By similarity). Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Found in the ruffled border (a late endosomal-like compartment in the plasma membrane) of bone-resorbing osteoclasts (By similarity).
Domain PF00071 Ras family
Function

Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3.; FUNCTION: Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction.

> Gene Ontology
 
Biological Process GO:0001667 ameboidal-type cell migration
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001818 negative regulation of cytokine production
GO:0001894 tissue homeostasis
GO:0001952 regulation of cell-matrix adhesion
GO:0001954 positive regulation of cell-matrix adhesion
GO:0002064 epithelial cell development
GO:0002065 columnar/cuboidal epithelial cell differentiation
GO:0002066 columnar/cuboidal epithelial cell development
GO:0002093 auditory receptor cell morphogenesis
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002551 mast cell chemotaxis
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0002831 regulation of response to biotic stimulus
GO:0003382 epithelial cell morphogenesis
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0006644 phospholipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0006909 phagocytosis
GO:0006911 phagocytosis, engulfment
GO:0006970 response to osmotic stress
GO:0006972 hyperosmotic response
GO:0007009 plasma membrane organization
GO:0007015 actin filament organization
GO:0007044 cell-substrate junction assembly
GO:0007045 cell-substrate adherens junction assembly
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007164 establishment of tissue polarity
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007270 neuron-neuron synaptic transmission
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007423 sensory organ development
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008064 regulation of actin polymerization or depolymerization
GO:0008154 actin polymerization or depolymerization
GO:0008361 regulation of cell size
GO:0008544 epidermis development
GO:0009612 response to mechanical stimulus
GO:0009615 response to virus
GO:0009913 epidermal cell differentiation
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010324 membrane invagination
GO:0010591 regulation of lamellipodium assembly
GO:0010592 positive regulation of lamellipodium assembly
GO:0010720 positive regulation of cell development
GO:0010761 fibroblast migration
GO:0010762 regulation of fibroblast migration
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0014041 regulation of neuron maturation
GO:0016055 Wnt signaling pathway
GO:0016358 dendrite development
GO:0019216 regulation of lipid metabolic process
GO:0021537 telencephalon development
GO:0021543 pallium development
GO:0021700 developmental maturation
GO:0021772 olfactory bulb development
GO:0021795 cerebral cortex cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021826 substrate-independent telencephalic tangential migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0021843 substrate-independent telencephalic tangential interneuron migration
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021885 forebrain cell migration
GO:0021889 olfactory bulb interneuron differentiation
GO:0021891 olfactory bulb interneuron development
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021894 cerebral cortex GABAergic interneuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0021987 cerebral cortex development
GO:0021988 olfactory lobe development
GO:0022028 tangential migration from the subventricular zone to the olfactory bulb
GO:0022029 telencephalon cell migration
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0030032 lamellipodium assembly
GO:0030038 contractile actin filament bundle assembly
GO:0030041 actin filament polymerization
GO:0030100 regulation of endocytosis
GO:0030168 platelet activation
GO:0030335 positive regulation of cell migration
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0030832 regulation of actin filament length
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0031032 actomyosin structure organization
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031334 positive regulation of protein complex assembly
GO:0031346 positive regulation of cell projection organization
GO:0031529 ruffle organization
GO:0031589 cell-substrate adhesion
GO:0032103 positive regulation of response to external stimulus
GO:0032231 regulation of actin filament bundle assembly
GO:0032233 positive regulation of actin filament bundle assembly
GO:0032271 regulation of protein polymerization
GO:0032273 positive regulation of protein polymerization
GO:0032535 regulation of cellular component size
GO:0032627 interleukin-23 production
GO:0032667 regulation of interleukin-23 production
GO:0032707 negative regulation of interleukin-23 production
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033674 positive regulation of kinase activity
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0034333 adherens junction assembly
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035023 regulation of Rho protein signal transduction
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035315 hair cell differentiation
GO:0035567 non-canonical Wnt signaling pathway
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0040017 positive regulation of locomotion
GO:0042110 T cell activation
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0042490 mechanoreceptor differentiation
GO:0042491 auditory receptor cell differentiation
GO:0042551 neuron maturation
GO:0042743 hydrogen peroxide metabolic process
GO:0043149 stress fiber assembly
GO:0043254 regulation of protein complex assembly
GO:0043277 apoptotic cell clearance
GO:0043550 regulation of lipid kinase activity
GO:0043551 regulation of phosphatidylinositol 3-kinase activity
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043583 ear development
GO:0043652 engulfment of apoptotic cell
GO:0043900 regulation of multi-organism process
GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism
GO:0044089 positive regulation of cellular component biogenesis
GO:0045216 cell-cell junction organization
GO:0045453 bone resorption
GO:0045730 respiratory burst
GO:0045740 positive regulation of DNA replication
GO:0045785 positive regulation of cell adhesion
GO:0045806 negative regulation of endocytosis
GO:0045834 positive regulation of lipid metabolic process
GO:0046578 regulation of Ras protein signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046849 bone remodeling
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048041 focal adhesion assembly
GO:0048259 regulation of receptor-mediated endocytosis
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048469 cell maturation
GO:0048532 anatomical structure arrangement
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048771 tissue remodeling
GO:0048813 dendrite morphogenesis
GO:0048839 inner ear development
GO:0048871 multicellular organismal homeostasis
GO:0048872 homeostasis of number of cells
GO:0048873 homeostasis of number of cells within a tissue
GO:0050688 regulation of defense response to virus
GO:0050690 regulation of defense response to virus by virus
GO:0050792 regulation of viral process
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051017 actin filament bundle assembly
GO:0051051 negative regulation of transport
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051258 protein polymerization
GO:0051272 positive regulation of cellular component movement
GO:0051492 regulation of stress fiber assembly
GO:0051493 regulation of cytoskeleton organization
GO:0051495 positive regulation of cytoskeleton organization
GO:0051496 positive regulation of stress fiber assembly
GO:0051607 defense response to virus
GO:0051668 localization within membrane
GO:0051893 regulation of focal adhesion assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0051932 synaptic transmission, GABAergic
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060113 inner ear receptor cell differentiation
GO:0060117 auditory receptor cell development
GO:0060119 inner ear receptor cell development
GO:0060249 anatomical structure homeostasis
GO:0060263 regulation of respiratory burst
GO:0060326 cell chemotaxis
GO:0060491 regulation of cell projection assembly
GO:0060563 neuroepithelial cell differentiation
GO:0060627 regulation of vesicle-mediated transport
GO:0061564 axon development
GO:0061572 actin filament bundle organization
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071496 cellular response to external stimulus
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0071593 lymphocyte aggregation
GO:0071621 granulocyte chemotaxis
GO:0071622 regulation of granulocyte chemotaxis
GO:0071624 positive regulation of granulocyte chemotaxis
GO:0072593 reactive oxygen species metabolic process
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090022 regulation of neutrophil chemotaxis
GO:0090023 positive regulation of neutrophil chemotaxis
GO:0090066 regulation of anatomical structure size
GO:0090102 cochlea development
GO:0090103 cochlea morphogenesis
GO:0090109 regulation of cell-substrate junction assembly
GO:0090175 regulation of establishment of planar polarity
GO:0090218 positive regulation of lipid kinase activity
GO:0090596 sensory organ morphogenesis
GO:0097154 GABAergic neuron differentiation
GO:0097178 ruffle assembly
GO:0097485 neuron projection guidance
GO:0097529 myeloid leukocyte migration
GO:0097530 granulocyte migration
GO:0097531 mast cell migration
GO:0097581 lamellipodium organization
GO:0098542 defense response to other organism
GO:0099024 plasma membrane invagination
GO:0198738 cell-cell signaling by wnt
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1901888 regulation of cell junction assembly
GO:1901890 positive regulation of cell junction assembly
GO:1902622 regulation of neutrophil migration
GO:1902624 positive regulation of neutrophil migration
GO:1902743 regulation of lamellipodium organization
GO:1902745 positive regulation of lamellipodium organization
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903391 regulation of adherens junction organization
GO:1903393 positive regulation of adherens junction organization
GO:1903429 regulation of cell maturation
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1904948 midbrain dopaminergic neuron differentiation
GO:1905330 regulation of morphogenesis of an epithelium
GO:1990266 neutrophil migration
GO:1990778 protein localization to cell periphery
GO:2000027 regulation of organ morphogenesis
GO:2000147 positive regulation of cell motility
GO:2000377 regulation of reactive oxygen species metabolic process
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0017016 Ras GTPase binding
GO:0017137 Rab GTPase binding
GO:0019001 guanyl nucleotide binding
GO:0030742 GTP-dependent protein binding
GO:0031267 small GTPase binding
GO:0031996 thioesterase binding
GO:0032561 guanyl ribonucleotide binding
GO:0042826 histone deacetylase binding
GO:0051020 GTPase binding
GO:0051021 GDP-dissociation inhibitor binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Cellular Component GO:0001726 ruffle
GO:0001891 phagocytic cup
GO:0005769 early endosome
GO:0005802 trans-Golgi network
GO:0005884 actin filament
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0010008 endosome membrane
GO:0015629 actin cytoskeleton
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0030055 cell-substrate junction
GO:0031252 cell leading edge
GO:0031253 cell projection membrane
GO:0031256 leading edge membrane
GO:0031901 early endosome membrane
GO:0031984 organelle subcompartment
GO:0032587 ruffle membrane
GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0044440 endosomal part
GO:0048770 pigment granule
GO:0098791 Golgi subcompartment
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04071 Sphingolipid signaling pathway
hsa04145 Phagosome
hsa04151 PI3K-Akt signaling pathway
hsa04310 Wnt signaling pathway
hsa04360 Axon guidance
hsa04370 VEGF signaling pathway
hsa04380 Osteoclast differentiation
hsa04510 Focal adhesion
hsa04520 Adherens junction
hsa04530 Tight junction
hsa04620 Toll-like receptor signaling pathway
hsa04650 Natural killer cell mediated cytotoxicity
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04670 Leukocyte transendothelial migration
hsa04722 Neurotrophin signaling pathway
hsa04810 Regulation of actin cytoskeleton
hsa04972 Pancreatic secretion
Reactome R-HSA-428540: Activation of Rac
R-HSA-1280218: Adaptive Immune System
R-HSA-422475: Axon guidance
R-HSA-3858494: Beta-catenin independent WNT signaling
R-HSA-389356: CD28 co-stimulation
R-HSA-389359: CD28 dependent Vav1 pathway
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE
R-HSA-1500931: Cell-Cell communication
R-HSA-388841: Costimulation by the CD28 family
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-418885: DCC mediated attractive signaling
R-HSA-376172: DSCAM interactions
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-2682334: EPH-Ephrin signaling
R-HSA-3928665: EPH-ephrin mediated repulsion of cells
R-HSA-3928662: EPHB-mediated forward signaling
R-HSA-3928664: Ephrin signaling
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-416482: G alpha (12/13) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-162906: HIV Infection
R-HSA-109582: Hemostasis
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168256: Immune System
R-HSA-428543: Inactivation of Cdc42 and Rac
R-HSA-5663205: Infectious disease
R-HSA-168249: Innate Immune System
R-HSA-373760: L1CAM interactions
R-HSA-5683057: MAPK family signaling cascades
R-HSA-5687128: MAPK6/MAPK4 signaling
R-HSA-8875555: MET activates RAP1 and RAC1
R-HSA-8875878: MET promotes cell motility
R-HSA-199991: Membrane Trafficking
R-HSA-193648: NRAGE signals death through JNK
R-HSA-164944: Nef and signal transduction
R-HSA-373752: Netrin-1 signaling
R-HSA-6798695: Neutrophil degranulation
R-HSA-4086400: PCP/CE pathway
R-HSA-8849471: PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-195258: RHO GTPase Effectors
R-HSA-5663220: RHO GTPases Activate Formins
R-HSA-5668599: RHO GTPases Activate NADPH Oxidases
R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs
R-HSA-5625900: RHO GTPases activate CIT
R-HSA-5626467: RHO GTPases activate IQGAPs
R-HSA-5625970: RHO GTPases activate KTN1
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-5625740: RHO GTPases activate PKNs
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-194840: Rho GTPase cycle
R-HSA-399955: SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399954: Sema3A PAK dependent Axon repulsion
R-HSA-400685: Sema4D in semaphorin signaling
R-HSA-416572: Sema4D induced cell migration and growth-cone collapse
R-HSA-416550: Sema4D mediated inhibition of cell attachment and migration
R-HSA-373755: Semaphorin interactions
R-HSA-162582: Signal Transduction
R-HSA-445144: Signal transduction by L1
R-HSA-372790: Signaling by GPCR
R-HSA-6806834: Signaling by MET
R-HSA-8848021: Signaling by PTK6
R-HSA-194315: Signaling by Rho GTPases
R-HSA-376176: Signaling by Robo receptor
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-194138: Signaling by VEGF
R-HSA-195721: Signaling by Wnt
R-HSA-166520: Signalling by NGF
R-HSA-164952: The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218920: VEGFR2 mediated vascular permeability
R-HSA-5653656: Vesicle-mediated transport
R-HSA-193704: p75 NTR receptor-mediated signalling
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between RAC1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between RAC1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
23325833leukemiaPromote immunityWe show that following the coculture of previously healthy T cells with CLL cells, subsequent LFA-1 engagement leads to altered Rho GTPase activation signaling by downregulating RhoA and Rac1, while upregulating Cdc42
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of RAC1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of RAC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0680.752
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0490.989
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0820.975
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2710.359
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1560.937
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.420.874
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.1390.78
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1670.944
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0790.976
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5530.808
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7750.829
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.180.0325
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of RAC1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.72.711
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.73.40.31
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of RAC1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of RAC1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by RAC1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of RAC1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of RAC1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between RAC1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolRAC1
Nameras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Aliases TC-25; p21-Rac1; Rac-1; MIG5; cell migration-inducing gene 5 protein; ras-like protein TC25; Ras-related C3 ......
Chromosomal Location7p22
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting RAC1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting RAC1.
ID Name Drug Type Targets #Targets
DB00514DextromethorphanSmall MoleculeCHRNA2, CHRNA3, CHRNA4, CHRNA7, CHRNB2, CHRNB4, CYBA, CYBB, GRIN3A ......21
DB00993AzathioprineSmall MoleculeHPRT1, RAC12
DB04315Guanosine-5'-DiphosphateSmall MoleculeADSSL1, ARF1, ARF4, ARF6, ARL1, ARL3, ARL5A, ARL5B, CDC42, EEF1A1, ......36