TISIDB

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm, cytoskeleton Nucleus Cell projection, dendritic spine Cell junction, synapse. Cell junction, adherens junction Cytoplasm. Cell membrane. Cell projection, lamellipodium. Cell projection, filopodium. Cell projection, ruffle membrane. Note=Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the postsynaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Domain	PF00595 PDZ domain (Also known as DHR or GLGF)
Function	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.

> Gene Ontology [ TOP ]
Biological Process	GO:0001558 regulation of cell growth GO:0001560 regulation of cell growth by extracellular stimulus GO:0007015 actin filament organization GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007088 regulation of mitotic nuclear division GO:0007096 regulation of exit from mitosis GO:0007346 regulation of mitotic cell cycle GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0008380 RNA splicing GO:0009991 response to extracellular stimulus GO:0010458 exit from mitosis GO:0014072 response to isoquinoline alkaloid GO:0016049 cell growth GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0030031 cell projection assembly GO:0030308 negative regulation of cell growth GO:0031668 cellular response to extracellular stimulus GO:0038003 opioid receptor signaling pathway GO:0043278 response to morphine GO:0043279 response to alkaloid GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0045786 negative regulation of cell cycle GO:0045926 negative regulation of growth GO:0046847 filopodium assembly GO:0050804 modulation of synaptic transmission GO:0051783 regulation of nuclear division GO:0071312 cellular response to alkaloid GO:0071315 cellular response to morphine GO:0071317 cellular response to isoquinoline alkaloid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:2000474 regulation of opioid receptor signaling pathway
Molecular Function	GO:0003779 actin binding GO:0004857 enzyme inhibitor activity GO:0004864 protein phosphatase inhibitor activity GO:0008157 protein phosphatase 1 binding GO:0019208 phosphatase regulator activity GO:0019212 phosphatase inhibitor activity GO:0019888 protein phosphatase regulator activity GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0051015 actin filament binding
Cellular Component	GO:0000164 protein phosphatase type 1 complex GO:0001726 ruffle GO:0008287 protein serine/threonine phosphatase complex GO:0014069 postsynaptic density GO:0015629 actin cytoskeleton GO:0030027 lamellipodium GO:0030175 filopodium GO:0030425 dendrite GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0032587 ruffle membrane GO:0043197 dendritic spine GO:0044309 neuron spine GO:0060076 excitatory synapse GO:0098794 postsynapse GO:0098858 actin-based cell projection GO:0099572 postsynaptic specialization GO:1903293 phosphatase complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between PPP1R9B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of PPP1R9B in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of PPP1R9B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.035	0.906
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.203	0.928
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.091	0.958
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.077	0.829
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.215	0.931
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.097	0.976
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.218	0.569
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.151	0.928
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.26	0.892
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.945	0.549
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.195	0.611
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.114	0.0664

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of PPP1R9B in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	14.8	0.00448
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	14.8	0.00826
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PPP1R9B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PPP1R9B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PPP1R9B. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PPP1R9B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of PPP1R9B expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between PPP1R9B and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	PPP1R9B
Name	protein phosphatase 1, regulatory subunit 9B
Aliases	SPINO; spinophilin; Neurabin-2; PPP1R9; protein phosphatase 1, regulatory subunit 9B, spinophilin; protein p ......
Chromosomal Location	17q21.33
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting PPP1R9B collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse PPP1R9B