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Browse PGLYRP1

Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted Cytoplasmic granule
Domain PF01510 N-acetylmuramoyl-L-alanine amidase
Function

Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.

> Gene Ontology
 
Biological Process GO:0000270 peptidoglycan metabolic process
GO:0001779 natural killer cell differentiation
GO:0001818 negative regulation of cytokine production
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0002325 natural killer cell differentiation involved in immune response
GO:0002366 leukocyte activation involved in immune response
GO:0002521 leukocyte differentiation
GO:0002683 negative regulation of immune system process
GO:0002694 regulation of leukocyte activation
GO:0002695 negative regulation of leukocyte activation
GO:0002697 regulation of immune effector process
GO:0002698 negative regulation of immune effector process
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0006022 aminoglycan metabolic process
GO:0006026 aminoglycan catabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0009253 peptidoglycan catabolic process
GO:0009595 detection of biotic stimulus
GO:0016045 detection of bacterium
GO:0030098 lymphocyte differentiation
GO:0030101 natural killer cell activation
GO:0030203 glycosaminoglycan metabolic process
GO:0031348 negative regulation of defense response
GO:0031349 positive regulation of defense response
GO:0032102 negative regulation of response to external stimulus
GO:0032609 interferon-gamma production
GO:0032649 regulation of interferon-gamma production
GO:0032689 negative regulation of interferon-gamma production
GO:0032814 regulation of natural killer cell activation
GO:0032815 negative regulation of natural killer cell activation
GO:0032823 regulation of natural killer cell differentiation
GO:0032824 negative regulation of natural killer cell differentiation
GO:0032826 regulation of natural killer cell differentiation involved in immune response
GO:0032827 negative regulation of natural killer cell differentiation involved in immune response
GO:0042742 defense response to bacterium
GO:0044110 growth involved in symbiotic interaction
GO:0044116 growth of symbiont involved in interaction with host
GO:0044117 growth of symbiont in host
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045619 regulation of lymphocyte differentiation
GO:0045620 negative regulation of lymphocyte differentiation
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050777 negative regulation of immune response
GO:0050830 defense response to Gram-positive bacterium
GO:0050865 regulation of cell activation
GO:0050866 negative regulation of cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051250 negative regulation of lymphocyte activation
GO:0098542 defense response to other organism
GO:0098543 detection of other organism
GO:0098581 detection of external biotic stimulus
GO:1901136 carbohydrate derivative catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1902105 regulation of leukocyte differentiation
GO:1902106 negative regulation of leukocyte differentiation
GO:1903706 regulation of hemopoiesis
GO:1903707 negative regulation of hemopoiesis
Molecular Function GO:0005539 glycosaminoglycan binding
GO:0008329 signaling pattern recognition receptor activity
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity
GO:0016019 peptidoglycan receptor activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0038187 pattern recognition receptor activity
GO:0042834 peptidoglycan binding
GO:0061783 peptidoglycan muralytic activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-6803157: Antimicrobial peptides
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-6798695: Neutrophil degranulation
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PGLYRP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PGLYRP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PGLYRP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.8870.0228
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.010.432
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7330.648
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6730.332
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2490.771
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1820.267
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PGLYRP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PGLYRP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PGLYRP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PGLYRP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PGLYRP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PGLYRP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPGLYRP1
Namepeptidoglycan recognition protein 1
Aliases TAG7; PGRP; PGRP-S; PGRPS; TNFSF3L; PGLYRP; peptidoglycan recognition protein; TNF superfamily, member 3 (LT ......
Chromosomal Location19q13.32
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PGLYRP1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.