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Browse PAM16

Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion inner membrane Peripheral membrane protein Matrix side
Domain -
Function

Regulates ATP-dependent protein translocation into the mitochondrial matrix. Inhibits DNAJC19 stimulation of HSPA9/Mortalin ATPase activity.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0017038 protein import
GO:0030150 protein import into mitochondrial matrix
GO:0032780 negative regulation of ATPase activity
GO:0043462 regulation of ATPase activity
GO:0044743 intracellular protein transmembrane import
GO:0051346 negative regulation of hydrolase activity
GO:0065002 intracellular protein transmembrane transport
GO:0070585 protein localization to mitochondrion
GO:0071806 protein transmembrane transport
GO:0072655 establishment of protein localization to mitochondrion
GO:1990542 mitochondrial transmembrane transport
Molecular Function -
Cellular Component GO:0001405 presequence translocase-associated import motor
GO:0005743 mitochondrial inner membrane
GO:0005744 mitochondrial inner membrane presequence translocase complex
GO:0005759 mitochondrial matrix
GO:0019898 extrinsic component of membrane
GO:0031312 extrinsic component of organelle membrane
GO:0031314 extrinsic component of mitochondrial inner membrane
GO:0044455 mitochondrial membrane part
GO:0098798 mitochondrial protein complex
GO:0098800 inner mitochondrial membrane protein complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-392499: Metabolism of proteins
R-HSA-1268020: Mitochondrial protein import
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between PAM16 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of PAM16 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.52 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of PAM16 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0580.875
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.2720.915
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2890.887
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0110.976
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.10.946
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1050.953
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.1680.423
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-1.6140.46
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0750.692
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of PAM16. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of PAM16. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by PAM16.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of PAM16. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of PAM16 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between PAM16 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolPAM16
Namepresequence translocase-associated motor 16 homolog (S. cerevisiae)
Aliases Magmas; Tim16; TIMM16; mitochondria associated protein involved in granulocyte macrophage colony stimulating ......
Chromosomal Location16p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting PAM16 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.