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Browse NTN1

Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted, extracellular space, extracellular matrix
Domain PF00053 Laminin EGF domain
PF00055 Laminin N-terminal (Domain VI)
PF01759 UNC-6/NTR/C345C module
Function

Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

> Gene Ontology
 
Biological Process GO:0001558 regulation of cell growth
GO:0001764 neuron migration
GO:0006929 substrate-dependent cell migration
GO:0006930 substrate-dependent cell migration, cell extension
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0007409 axonogenesis
GO:0007411 axon guidance
GO:0007423 sensory organ development
GO:0008361 regulation of cell size
GO:0010720 positive regulation of cell development
GO:0010721 negative regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010771 negative regulation of cell morphogenesis involved in differentiation
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0010977 negative regulation of neuron projection development
GO:0016049 cell growth
GO:0022604 regulation of cell morphogenesis
GO:0022612 gland morphogenesis
GO:0030031 cell projection assembly
GO:0030307 positive regulation of cell growth
GO:0030308 negative regulation of cell growth
GO:0030516 regulation of axon extension
GO:0030517 negative regulation of axon extension
GO:0030879 mammary gland development
GO:0031345 negative regulation of cell projection organization
GO:0031346 positive regulation of cell projection organization
GO:0032488 Cdc42 protein signal transduction
GO:0032535 regulation of cellular component size
GO:0033564 anterior/posterior axon guidance
GO:0035239 tube morphogenesis
GO:0040017 positive regulation of locomotion
GO:0040023 establishment of nucleus localization
GO:0042471 ear morphogenesis
GO:0042472 inner ear morphogenesis
GO:0043583 ear development
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045773 positive regulation of axon extension
GO:0045926 negative regulation of growth
GO:0045927 positive regulation of growth
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048639 positive regulation of developmental growth
GO:0048640 negative regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048675 axon extension
GO:0048732 gland development
GO:0048839 inner ear development
GO:0050768 negative regulation of neurogenesis
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050771 negative regulation of axonogenesis
GO:0050772 positive regulation of axonogenesis
GO:0051272 positive regulation of cellular component movement
GO:0051640 organelle localization
GO:0051647 nucleus localization
GO:0051656 establishment of organelle localization
GO:0051961 negative regulation of nervous system development
GO:0051962 positive regulation of nervous system development
GO:0060443 mammary gland morphogenesis
GO:0060560 developmental growth involved in morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060603 mammary gland duct morphogenesis
GO:0061180 mammary gland epithelium development
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0090066 regulation of anatomical structure size
GO:0090596 sensory organ morphogenesis
GO:0097485 neuron projection guidance
GO:1990138 neuron projection extension
GO:2000147 positive regulation of cell motility
Molecular Function -
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0044420 extracellular matrix component
> KEGG and Reactome Pathway
 
KEGG hsa04360 Axon guidance
Reactome R-HSA-422475: Axon guidance
R-HSA-1500931: Cell-Cell communication
R-HSA-418885: DCC mediated attractive signaling
R-HSA-376172: DSCAM interactions
R-HSA-1266738: Developmental Biology
R-HSA-418886: Netrin mediated repulsion signals
R-HSA-373752: Netrin-1 signaling
R-HSA-418890: Role of second messengers in netrin-1 signaling
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NTN1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NTN1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NTN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.6530.0396
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.970.0771
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4160.372
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4160.356
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.5070.732
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3030.873
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.440.448
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.4250.0919
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7630.42
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6380.24
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.710.324
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.1090.686
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NTN1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NTN1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NTN1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NTN1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NTN1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NTN1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NTN1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNTN1
Namenetrin 1
Aliases NTN1L; Netrin-1; epididymis tissue protein Li 131P; netrin 1, mouse, homolog of
Chromosomal Location17p13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NTN1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.