[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse NKD2

Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Cytoplasm Cytoplasmic vesicle
Domain -
Function

Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity (By similarity). Required for processing of TGFA and for targeting of TGFA to the basolateral membrane of polarized epithelial cells.

> Gene Ontology
 
Biological Process GO:0006612 protein targeting to membrane
GO:0006887 exocytosis
GO:0006906 vesicle fusion
GO:0007009 plasma membrane organization
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0010498 proteasomal protein catabolic process
GO:0010954 positive regulation of protein processing
GO:0016050 vesicle organization
GO:0016055 Wnt signaling pathway
GO:0016485 protein processing
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0042176 regulation of protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044801 single-organism membrane fusion
GO:0045732 positive regulation of protein catabolic process
GO:0045862 positive regulation of proteolysis
GO:0048193 Golgi vesicle transport
GO:0048210 Golgi vesicle fusion to target membrane
GO:0048284 organelle fusion
GO:0051604 protein maturation
GO:0060070 canonical Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061025 membrane fusion
GO:0061136 regulation of proteasomal protein catabolic process
GO:0070613 regulation of protein processing
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090150 establishment of protein localization to membrane
GO:0090174 organelle membrane fusion
GO:0198738 cell-cell signaling by wnt
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903076 regulation of protein localization to plasma membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903317 regulation of protein maturation
GO:1903319 positive regulation of protein maturation
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903729 regulation of plasma membrane organization
GO:1903829 positive regulation of cellular protein localization
GO:1904375 regulation of protein localization to cell periphery
GO:1904377 positive regulation of protein localization to cell periphery
GO:1904951 positive regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
Molecular Function GO:0019838 growth factor binding
GO:0031625 ubiquitin protein ligase binding
GO:0044389 ubiquitin-like protein ligase binding
Cellular Component GO:0016323 basolateral plasma membrane
GO:0016328 lateral plasma membrane
> KEGG and Reactome Pathway
 
KEGG hsa04310 Wnt signaling pathway
Reactome -
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between NKD2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of NKD2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of NKD2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5680.19
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.6630.0285
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2240.754
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.0870.0344
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.8820.613
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.3470.54
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2960.634
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1240.892
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.360.704
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.8870.348
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.2950.81
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1710.434
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of NKD2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of NKD2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of NKD2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by NKD2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of NKD2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of NKD2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between NKD2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolNKD2
Namenaked cuticle homolog 2 (Drosophila)
Aliases Naked2; naked cuticle-2; Dvl-binding protein NKD2; hNkd2; Naked-2; Protein naked cuticle homolog 2
Chromosomal Location5p15.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting NKD2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.