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Browse MYF6

Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF01586 Myogenic Basic domain
PF00010 Helix-loop-helix DNA-binding domain
Function

Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.

> Gene Ontology
 
Biological Process GO:0000768 syncytium formation by plasma membrane fusion
GO:0001756 somitogenesis
GO:0003002 regionalization
GO:0006949 syncytium formation
GO:0007389 pattern specification process
GO:0007517 muscle organ development
GO:0007519 skeletal muscle tissue development
GO:0007520 myoblast fusion
GO:0009952 anterior/posterior pattern specification
GO:0010720 positive regulation of cell development
GO:0010830 regulation of myotube differentiation
GO:0010831 positive regulation of myotube differentiation
GO:0014706 striated muscle tissue development
GO:0014902 myotube differentiation
GO:0014904 myotube cell development
GO:0016202 regulation of striated muscle tissue development
GO:0031099 regeneration
GO:0035282 segmentation
GO:0035914 skeletal muscle cell differentiation
GO:0042246 tissue regeneration
GO:0042692 muscle cell differentiation
GO:0042693 muscle cell fate commitment
GO:0043403 skeletal muscle tissue regeneration
GO:0045165 cell fate commitment
GO:0045445 myoblast differentiation
GO:0045661 regulation of myoblast differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045844 positive regulation of striated muscle tissue development
GO:0048634 regulation of muscle organ development
GO:0048636 positive regulation of muscle organ development
GO:0048641 regulation of skeletal muscle tissue development
GO:0048643 positive regulation of skeletal muscle tissue development
GO:0048644 muscle organ morphogenesis
GO:0048741 skeletal muscle fiber development
GO:0048742 regulation of skeletal muscle fiber development
GO:0048743 positive regulation of skeletal muscle fiber development
GO:0048747 muscle fiber development
GO:0051146 striated muscle cell differentiation
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051153 regulation of striated muscle cell differentiation
GO:0051155 positive regulation of striated muscle cell differentiation
GO:0055001 muscle cell development
GO:0055002 striated muscle cell development
GO:0060142 regulation of syncytium formation by plasma membrane fusion
GO:0060143 positive regulation of syncytium formation by plasma membrane fusion
GO:0060415 muscle tissue morphogenesis
GO:0060537 muscle tissue development
GO:0060538 skeletal muscle organ development
GO:0061053 somite development
GO:1901739 regulation of myoblast fusion
GO:1901741 positive regulation of myoblast fusion
GO:1901861 regulation of muscle tissue development
GO:1901863 positive regulation of muscle tissue development
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0046982 protein heterodimerization activity
GO:0070888 E-box binding
Cellular Component GO:0005667 transcription factor complex
GO:0044798 nuclear transcription factor complex
GO:0090575 RNA polymerase II transcription factor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-375170: CDO in myogenesis
R-HSA-1266738: Developmental Biology
R-HSA-525793: Myogenesis
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MYF6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MYF6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.57 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MYF6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2920.283
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.1260.832
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4180.413
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.4440.114
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.5860.313
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.270.513
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.6770.437
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.6770.562
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.3420.11
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MYF6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103033.3-33.30.231
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MYF6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MYF6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MYF6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MYF6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MYF6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MYF6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMYF6
Namemyogenic factor 6 (herculin)
Aliases MRF4; bHLHc4; muscle-specific regulatory factor 4; CNM3; myf-6; class C basic helix-loop-helix protein 4; My ......
Chromosomal Location12q21.31
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MYF6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.