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Browse MOV10L1

Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis.
Domain -
Function

ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

> Gene Ontology
 
Biological Process GO:0006304 DNA modification
GO:0006305 DNA alkylation
GO:0006306 DNA methylation
GO:0007126 meiotic nuclear division
GO:0007127 meiosis I
GO:0007140 male meiosis
GO:0007141 male meiosis I
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0032259 methylation
GO:0034587 piRNA metabolic process
GO:0043046 DNA methylation involved in gamete generation
GO:0043414 macromolecule methylation
GO:0044728 DNA methylation or demethylation
GO:0048232 male gamete generation
GO:0051321 meiotic cell cycle
GO:1903046 meiotic cell cycle process
Molecular Function GO:0000287 magnesium ion binding
GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0008026 ATP-dependent helicase activity
GO:0008186 RNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0042623 ATPase activity, coupled
GO:0070035 purine NTP-dependent helicase activity
Cellular Component GO:0035770 ribonucleoprotein granule
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043186 P granule
GO:0045495 pole plasm
GO:0060293 germ plasm
GO:0071546 pi-body
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-74160: Gene Expression
R-HSA-211000: Gene Silencing by RNA
R-HSA-5601884: PIWI-interacting RNA (piRNA) biogenesis
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between MOV10L1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of MOV10L1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of MOV10L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1370.533
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.1750.754
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1160.757
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.3340.0227
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.3970.263
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.2510.419
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.1980.075
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9880.405
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11121.460.253
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4410.371
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.7040.3
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2980.121
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of MOV10L1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.86.880.247
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.88.56.30.453
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.55.93.61
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.49.16.31
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MOV10L1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MOV10L1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MOV10L1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MOV10L1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of MOV10L1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between MOV10L1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolMOV10L1
NameMov10 RISC complex RNA helicase like 1
Aliases DJ402G11.8; DKFZp434B0717; cardiac helicase activated by MEF2C protein; Mov10 (mouse)-like 1; Mov10l1, Molon ......
Chromosomal Location22q13.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting MOV10L1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.