TISIDB

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Nucleus
Domain	PF00069 Protein kinase domain
Function	Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (PubMed:10747973). ; FUNCTION: JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

> Gene Ontology [ TOP ]
Biological Process	GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:0002237 response to molecule of bacterial origin GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0006476 protein deacetylation GO:0006839 mitochondrial transport GO:0006914 autophagy GO:0007006 mitochondrial membrane organization GO:0007254 JNK cascade GO:0007258 JUN phosphorylation GO:0007623 circadian rhythm GO:0008637 apoptotic mitochondrial changes GO:0009314 response to radiation GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009612 response to mechanical stimulus GO:0010506 regulation of autophagy GO:0010821 regulation of mitochondrion organization GO:0010822 positive regulation of mitochondrion organization GO:0016236 macroautophagy GO:0016241 regulation of macroautophagy GO:0016570 histone modification GO:0016575 histone deacetylation GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0031056 regulation of histone modification GO:0031063 regulation of histone deacetylation GO:0031098 stress-activated protein kinase signaling cascade GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0032091 negative regulation of protein binding GO:0032496 response to lipopolysaccharide GO:0035601 protein deacylation GO:0035794 positive regulation of mitochondrial membrane permeability GO:0038093 Fc receptor signaling pathway GO:0038095 Fc-epsilon receptor signaling pathway GO:0042752 regulation of circadian rhythm GO:0043393 regulation of protein binding GO:0046902 regulation of mitochondrial membrane permeability GO:0048511 rhythmic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051204 protein insertion into mitochondrial membrane GO:0051205 protein insertion into membrane GO:0051403 stress-activated MAPK cascade GO:0070585 protein localization to mitochondrion GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071396 cellular response to lipid GO:0071496 cellular response to external stimulus GO:0072655 establishment of protein localization to mitochondrion GO:0072657 protein localization to membrane GO:0090045 positive regulation of deacetylase activity GO:0090150 establishment of protein localization to membrane GO:0090311 regulation of protein deacetylation GO:0090559 regulation of membrane permeability GO:0097345 mitochondrial outer membrane permeabilization GO:0098732 macromolecule deacylation GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:1902275 regulation of chromatin organization GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death GO:1903747 regulation of establishment of protein localization to mitochondrion GO:1903749 positive regulation of establishment of protein localization to mitochondrion GO:1903829 positive regulation of cellular protein localization GO:1904951 positive regulation of establishment of protein localization GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway
Molecular Function	GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004705 JUN kinase activity GO:0004707 MAP kinase activity GO:0005057 receptor signaling protein activity GO:0016909 SAP kinase activity GO:0035033 histone deacetylase regulator activity GO:0042826 histone deacetylase binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04024 cAMP signaling pathway hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04140 Regulation of autophagy hsa04141 Protein processing in endoplasmic reticulum hsa04210 Apoptosis hsa04310 Wnt signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04530 Tight junction hsa04620 Toll-like receptor signaling pathway hsa04621 NOD-like receptor signaling pathway hsa04622 RIG-I-like receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04723 Retrograde endocannabinoid signaling hsa04728 Dopaminergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04910 Insulin signaling pathway hsa04912 GnRH signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04917 Prolactin signaling pathway hsa04920 Adipocytokine signaling pathway
Reactome	R-HSA-166054: Activated TLR4 signalling R-HSA-114452: Activation of BH3-only proteins R-HSA-111446: Activation of BIM and translocation to mitochondria R-HSA-139910: Activation of BMF and translocation to mitochondria R-HSA-450341: Activation of the AP-1 family of transcription factors R-HSA-109581: Apoptosis R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE R-HSA-1500931: Cell-Cell communication R-HSA-2559583: Cellular Senescence R-HSA-2262752: Cellular responses to stress R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-376172: DSCAM interactions R-HSA-2871796: FCERI mediated MAPK activation R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450294: MAP kinase activation in TLR cascade R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-975871: MyD88 cascade initiated on plasma membrane R-HSA-975155: MyD88 dependent cascade initiated on endosome R-HSA-166166: MyD88-independent TLR3/TLR4 cascade R-HSA-166058: MyD88 R-HSA-193648: NRAGE signals death through JNK R-HSA-205043: NRIF signals cell death from the nucleus R-HSA-2559580: Oxidative Stress Induced Senescence R-HSA-5357801: Programmed Cell Death R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-162582: Signal Transduction R-HSA-166520: Signalling by NGF R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade R-HSA-168179: Toll Like Receptor TLR1 R-HSA-168188: Toll Like Receptor TLR6 R-HSA-168898: Toll-Like Receptors Cascades R-HSA-193704: p75 NTR receptor-mediated signalling

> KEGG and Reactome Pathway

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KEGG

hsa04010 MAPK signaling pathway
hsa04012 ErbB signaling pathway
hsa04014 Ras signaling pathway
hsa04024 cAMP signaling pathway
hsa04068 FoxO signaling pathway
hsa04071 Sphingolipid signaling pathway
hsa04140 Regulation of autophagy
hsa04141 Protein processing in endoplasmic reticulum
hsa04210 Apoptosis
hsa04310 Wnt signaling pathway
hsa04380 Osteoclast differentiation
hsa04510 Focal adhesion
hsa04530 Tight junction
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04668 TNF signaling pathway
hsa04722 Neurotrophin signaling pathway
hsa04723 Retrograde endocannabinoid signaling
hsa04728 Dopaminergic synapse
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04910 Insulin signaling pathway
hsa04912 GnRH signaling pathway
hsa04914 Progesterone-mediated oocyte maturation
hsa04917 Prolactin signaling pathway
hsa04920 Adipocytokine signaling pathway

Reactome

R-HSA-166054: Activated TLR4 signalling
R-HSA-114452: Activation of BH3-only proteins
R-HSA-111446: Activation of BIM and translocation to mitochondria
R-HSA-139910: Activation of BMF and translocation to mitochondria
R-HSA-450341: Activation of the AP-1 family of transcription factors
R-HSA-109581: Apoptosis
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE
R-HSA-1500931: Cell-Cell communication
R-HSA-2559583: Cellular Senescence
R-HSA-2262752: Cellular responses to stress
R-HSA-5693606: DNA Double Strand Break Response
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-376172: DSCAM interactions
R-HSA-2871796: FCERI mediated MAPK activation
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-450321: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-450294: MAP kinase activation in TLR cascade
R-HSA-450282: MAPK targets/ Nuclear events mediated by MAP kinases
R-HSA-975871: MyD88 cascade initiated on plasma membrane
R-HSA-975155: MyD88 dependent cascade initiated on endosome
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-166058: MyD88
R-HSA-193648: NRAGE signals death through JNK
R-HSA-205043: NRIF signals cell death from the nucleus
R-HSA-2559580: Oxidative Stress Induced Senescence
R-HSA-5357801: Programmed Cell Death
R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-162582: Signal Transduction
R-HSA-166520: Signalling by NGF
R-HSA-168180: TRAF6 Mediated Induction of proinflammatory cytokines
R-HSA-975138: TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-168142: Toll Like Receptor 10 (TLR10) Cascade
R-HSA-181438: Toll Like Receptor 2 (TLR2) Cascade
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168176: Toll Like Receptor 5 (TLR5) Cascade
R-HSA-168181: Toll Like Receptor 7/8 (TLR7/8) Cascade
R-HSA-168138: Toll Like Receptor 9 (TLR9) Cascade
R-HSA-168179: Toll Like Receptor TLR1
R-HSA-168188: Toll Like Receptor TLR6
R-HSA-168898: Toll-Like Receptors Cascades
R-HSA-193704: p75 NTR receptor-mediated signalling

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MAPK8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between MAPK8 and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
23935194	Melanoma	Promote immunity	We also show that the AICD in TCReng CD4 T cells is a death receptor-independent process and that JNK and p53 play critical roles in this process as pharmacological inhibitors targeting JNK activation and p-53-mediated transcription-independent mitochondria-centric death cascade rescued a significant fraction of TCReng CD4 T cells from undergoing AICD without affecting their effector function.
16237070	Melanoma; Lymphoma	Promote immunity (T cell function)	JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. JNK1-/- CD8+ T cells have an intrinsic defect in early IFN-gamma gene transcription and production after activation by either anti-CD3/anti-CD28 Abs or dendritic cells loaded with specific Ag in vitro. The impaired IFN-gamma production in JNK1-/- CD8+ T cells is associated with reduced expression of both T-bet and Eomesodermin, indicating that JNK1 regulates the transcription program of CD8+ T cells. Finally, JNK1-/- CD8+ T cells showed reduced perforin expression and impaired CTL function.

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of MAPK8 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MAPK8 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.105	0.673
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.155	0.888
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.063	0.932
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.297	0.365
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.524	0.718
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.009	0.996
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.062	0.825
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.095	0.927
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.016	0.989
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.912	0.432
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.193	0.9
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.032	0.57

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MAPK8 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	7.4	7.4	0.0709
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	7.4	7.4	0.096
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAPK8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAPK8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAPK8. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAPK8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MAPK8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MAPK8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MAPK8
Name	mitogen-activated protein kinase 8
Aliases	JNK; JNK1; SAPK1; JUN N-terminal kinase; PRKM8; JNK-46; JNK1A2; JNK21B1/2; SAPK1c; MAP kinase 8; c-Jun N-ter ......
Chromosomal Location	10q11
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MAPK8 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting MAPK8.

ID	Name	Drug Type	Targets	#Targets
DB01782	2,6-Dihydroanthra/1,9-Cd/Pyrazol-6-One	Small Molecule	MAPK10, MAPK8, MAPK8IP1, TTK	4
DB07218	6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE	Small Molecule	MAPK8, MAPK8IP1	2
DB07268	2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE	Small Molecule	MAPK8	1
DB07272	N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE	Small Molecule	MAPK8, MAPK8IP1	2
DB07276	5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE	Small Molecule	MAPK8, MAPK8IP1	2
DB07845	2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide	Small Molecule	MAPK8	1

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