TISIDB

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase.
Domain	PF00069 Protein kinase domain
Function	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells.

> Gene Ontology [ TOP ]
Biological Process	GO:0001894 tissue homeostasis GO:0001895 retina homeostasis GO:0007283 spermatogenesis GO:0010639 negative regulation of organelle organization GO:0010927 cellular component assembly involved in morphogenesis GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0031345 negative regulation of cell projection organization GO:0035058 nonmotile primary cilium assembly GO:0042384 cilium assembly GO:0044782 cilium organization GO:0045494 photoreceptor cell maintenance GO:0046777 protein autophosphorylation GO:0048232 male gamete generation GO:0048871 multicellular organismal homeostasis GO:0060249 anatomical structure homeostasis GO:0060271 cilium morphogenesis GO:0060491 regulation of cell projection assembly GO:1902017 regulation of cilium assembly GO:1902018 negative regulation of cilium assembly GO:1902115 regulation of organelle assembly GO:1902116 negative regulation of organelle assembly GO:1902855 regulation of nonmotile primary cilium assembly GO:1902856 negative regulation of nonmotile primary cilium assembly
Molecular Function	GO:0003713 transcription coactivator activity GO:0004674 protein serine/threonine kinase activity GO:0004693 cyclin-dependent protein serine/threonine kinase activity GO:0097472 cyclin-dependent protein kinase activity
Cellular Component	GO:0001750 photoreceptor outer segment GO:0001917 photoreceptor inner segment GO:0005813 centrosome GO:0005819 spindle GO:0005929 cilium GO:0005930 axoneme GO:0030496 midbody GO:0031513 nonmotile primary cilium GO:0031514 motile cilium GO:0032391 photoreceptor connecting cilium GO:0044441 ciliary part GO:0072372 primary cilium GO:0072686 mitotic spindle GO:0097014 ciliary plasm GO:0097542 ciliary tip

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	-

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between MAK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of MAK in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of MAK in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.133	0.449
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.286	0.543
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.027	0.932
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.238	0.571
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.107	0.957
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.405	0.872
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.232	0.473
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.27	0.607
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.105	0.851
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.142	0.737
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-0.097	0.868
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.243	0.352

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of MAK in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	14.8	1.4	13.4	0.0181
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	14.8	1.7	13.1	0.032
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	0	0	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	0	0	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	5.3	3.7	1.6	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	0	4.5	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	7.1	-0.9	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of MAK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of MAK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by MAK. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of MAK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of MAK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between MAK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	MAK
Name	male germ cell-associated kinase
Aliases	dJ417M14.2; RP62; male germ cell-associated kinase retinal-enriched isoform; serine/threonine protein kinase ......
Chromosomal Location	6p24.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting MAK collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse MAK