TISIDB

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm Nucleus
Domain	PF00514 Armadillo/beta-catenin-like repeat PF16186 Atypical Arm repeat PF01749 Importin beta binding domain
Function	Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

> Gene Ontology [ TOP ]
Biological Process	GO:0000018 regulation of DNA recombination GO:0000737 DNA catabolic process, endonucleolytic GO:0006308 DNA catabolic process GO:0006309 apoptotic DNA fragmentation GO:0006310 DNA recombination GO:0006606 protein import into nucleus GO:0006607 NLS-bearing protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0017038 protein import GO:0019048 modulation by virus of host morphology or physiology GO:0019054 modulation by virus of host process GO:0019058 viral life cycle GO:0019439 aromatic compound catabolic process GO:0030262 apoptotic nuclear changes GO:0034504 protein localization to nucleus GO:0034655 nucleobase-containing compound catabolic process GO:0035821 modification of morphology or physiology of other organism GO:0044003 modification by symbiont of host morphology or physiology GO:0044068 modulation by symbiont of host cellular process GO:0044270 cellular nitrogen compound catabolic process GO:0044744 protein targeting to nucleus GO:0044766 multi-organism transport GO:0046700 heterocycle catabolic process GO:0046794 transport of virus GO:0051052 regulation of DNA metabolic process GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051701 interaction with host GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction GO:0075733 intracellular transport of virus GO:0090305 nucleic acid phosphodiester bond hydrolysis GO:0097194 execution phase of apoptosis GO:1901361 organic cyclic compound catabolic process GO:1902579 multi-organism localization GO:1902581 multi-organism cellular localization GO:1902583 multi-organism intracellular transport GO:1902593 single-organism nuclear import
Molecular Function	GO:0005048 signal sequence binding GO:0008139 nuclear localization sequence binding GO:0008565 protein transporter activity GO:0033218 amide binding GO:0042277 peptide binding
Cellular Component	GO:0005635 nuclear envelope GO:0005643 nuclear pore GO:0030425 dendrite

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-168276: NS1 Mediated Effects on Host Pathways R-HSA-211227: Activation of DNA fragmentation factor R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes R-HSA-109581: Apoptosis R-HSA-140342: Apoptosis induced DNA fragmentation R-HSA-75153: Apoptotic execution phase R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-1643685: Disease R-HSA-162594: Early Phase of HIV Life Cycle R-HSA-162906: HIV Infection R-HSA-162587: HIV Life Cycle R-HSA-162909: Host Interactions of HIV factors R-HSA-168253: Host Interactions with Influenza Factors R-HSA-1169408: ISG15 antiviral mechanism R-HSA-168256: Immune System R-HSA-5663205: Infectious disease R-HSA-168254: Influenza Infection R-HSA-168255: Influenza Life Cycle R-HSA-162592: Integration of provirus R-HSA-176033: Interactions of Vpr with host cellular proteins R-HSA-913531: Interferon Signaling R-HSA-5357801: Programmed Cell Death R-HSA-168271: Transport of Ribonucleoproteins into the Host Nucleus R-HSA-180910: Vpr-mediated nuclear import of PICs

> KEGG and Reactome Pathway

[ TOP ]

KEGG

Reactome

R-HSA-168276: NS1 Mediated Effects on Host Pathways
R-HSA-211227: Activation of DNA fragmentation factor
R-HSA-1169410: Antiviral mechanism by IFN-stimulated genes
R-HSA-109581: Apoptosis
R-HSA-140342: Apoptosis induced DNA fragmentation
R-HSA-75153: Apoptotic execution phase
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-1643685: Disease
R-HSA-162594: Early Phase of HIV Life Cycle
R-HSA-162906: HIV Infection
R-HSA-162587: HIV Life Cycle
R-HSA-162909: Host Interactions of HIV factors
R-HSA-168253: Host Interactions with Influenza Factors
R-HSA-1169408: ISG15 antiviral mechanism
R-HSA-168256: Immune System
R-HSA-5663205: Infectious disease
R-HSA-168254: Influenza Infection
R-HSA-168255: Influenza Life Cycle
R-HSA-162592: Integration of provirus
R-HSA-176033: Interactions of Vpr with host cellular proteins
R-HSA-913531: Interferon Signaling
R-HSA-5357801: Programmed Cell Death
R-HSA-168271: Transport of Ribonucleoproteins into the Host Nucleus
R-HSA-180910: Vpr-mediated nuclear import of PICs

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between KPNA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of KPNA1 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.57	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the expression difference of KPNA1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.006	0.979
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.352	0.833
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.244	0.835
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0.165	0.585
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.081	0.967
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.273	0.914
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.1	0.817
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.155	0.932
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.018	0.993
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.522	0.695
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.628	0.375
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	0.035	0.47

> Mutation difference between responders and non-responders

[ TOP ]

Points in the above scatter plot represent the mutation difference of KPNA1 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	1.4	2.3	0.469
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	1.7	2	0.532
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	11.1	0	11.1	0.36
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	20	0	20	0.357
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of KPNA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of KPNA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by KPNA1. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of KPNA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of KPNA1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between KPNA1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	KPNA1
Name	karyopherin alpha 1 (importin alpha 5)
Aliases	RCH2; NPI-1; IPOA5; RAG cohort protein 2; SRP1-beta; importin alpha 5; importin-alpha-S1; karyopherin subuni ......
Chromosomal Location	3q21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting KPNA1 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

Browse KPNA1