[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse IRGM

Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Golgi apparatus membrane Cell membrane Cytoplasmic vesicle, phagosome membrane Cytoplasmic vesicle, autophagosome membrane Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Domain PF05049 Interferon-inducible GTPase (IIGP)
Function

Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).

> Gene Ontology
 
Biological Process GO:0006914 autophagy
GO:0035456 response to interferon-beta
GO:0035458 cellular response to interferon-beta
Molecular Function GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0032561 guanyl ribonucleotide binding
Cellular Component GO:0000421 autophagosome membrane
GO:0001891 phagocytic cup
GO:0005776 autophagosome
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0045335 phagocytic vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between IRGM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of IRGM in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell logFC: -2.16; FDR: 0.04170 Resistant to T cell-mediated killing
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of IRGM in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3770.434
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6290.536
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.6460.168
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.2280.598
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.4550.479
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3030.156
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of IRGM in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IRGM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IRGM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IRGM.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IRGM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of IRGM expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between IRGM and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolIRGM
Nameimmunity-related GTPase family, M
Aliases LRG47; LRG-47; IFI1; IRGM1; immunity-related GTPase family, M1; IFI11; LPS-stimulated RAW 264.7 macrophage p ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting IRGM collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.