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Browse INPP5B

Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol Endoplasmic reticulum-Golgi intermediate compartment Early endosome membrane Membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic vesicle, phagosome membrane Golgi apparatus
Domain PF03372 Endonuclease/Exonuclease/phosphatase family
PF16776 Type II inositol 1
PF00620 RhoGAP domain
Function

Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.

> Gene Ontology
 
Biological Process GO:0001701 in utero embryonic development
GO:0006066 alcohol metabolic process
GO:0006644 phospholipid metabolic process
GO:0006650 glycerophospholipid metabolic process
GO:0007283 spermatogenesis
GO:0016311 dephosphorylation
GO:0016485 protein processing
GO:0019751 polyol metabolic process
GO:0030258 lipid modification
GO:0030317 flagellated sperm motility
GO:0043647 inositol phosphate metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0046839 phospholipid dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048232 male gamete generation
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051604 protein maturation
GO:0070613 regulation of protein processing
GO:0097722 sperm motility
GO:1901615 organic hydroxy compound metabolic process
GO:1903317 regulation of protein maturation
Molecular Function GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005096 GTPase activator activity
GO:0008047 enzyme activator activity
GO:0016791 phosphatase activity
GO:0030695 GTPase regulator activity
GO:0034593 phosphatidylinositol bisphosphate phosphatase activity
GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0046030 inositol trisphosphate phosphatase activity
GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052743 inositol tetrakisphosphate phosphatase activity
GO:0052745 inositol phosphate phosphatase activity
GO:0052866 phosphatidylinositol phosphate phosphatase activity
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component GO:0005769 early endosome
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0010008 endosome membrane
GO:0030139 endocytic vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0030670 phagocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0044440 endosomal part
GO:0045335 phagocytic vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04070 Phosphatidylinositol signaling system
hsa00562 Inositol phosphate metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-1483249: Inositol phosphate metabolism
R-HSA-1430728: Metabolism
R-HSA-194840: Rho GTPase cycle
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-1855183: Synthesis of IP2, IP, and Ins in the cytosol
R-HSA-1855204: Synthesis of IP3 and IP4 in the cytosol
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between INPP5B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of INPP5B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen Total # shRNA with >= 4-fold: 5 Resistant to T-cell proliferation
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of INPP5B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2210.301
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.20.871
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2380.794
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0050.985
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1530.934
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1840.939
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0970.737
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2260.866
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0250.987
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2180.812
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.170.894
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0010.984
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of INPP5B in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.407.40.0709
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.407.40.096
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.811.8-70.577
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.533.3-20.80.538
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of INPP5B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of INPP5B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by INPP5B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of INPP5B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of INPP5B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between INPP5B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolINPP5B
Nameinositol polyphosphate-5-phosphatase B
Aliases inositol polyphosphate-5-phosphatase, 75kD; inositol polyphosphate-5-phosphatase, 75kDa; 75 kDa inositol pol ......
Chromosomal Location1p34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting INPP5B collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting INPP5B.
ID Name Drug Type Targets #Targets
DB03158D-Myo-Inositol-1,4-BisphosphateSmall MoleculeINPP5B1