TISIDB

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Isoform 1: Secreted.; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.; SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.
Domain	PF00340 Interleukin-1 / 18
Function	Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. Binds functional interleukin-1 receptor IL1R1 with greater affinity than decoy receptor IL1R2; however, the physiological relevance of the latter association is unsure.

> Gene Ontology [ TOP ]
Biological Process	GO:0001959 regulation of cytokine-mediated signaling pathway GO:0001960 negative regulation of cytokine-mediated signaling pathway GO:0002790 peptide secretion GO:0007162 negative regulation of cell adhesion GO:0007369 gastrulation GO:0009306 protein secretion GO:0009914 hormone transport GO:0010470 regulation of gastrulation GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0031960 response to corticosteroid GO:0034113 heterotypic cell-cell adhesion GO:0034114 regulation of heterotypic cell-cell adhesion GO:0034115 negative regulation of heterotypic cell-cell adhesion GO:0042886 amide transport GO:0045995 regulation of embryonic development GO:0046879 hormone secretion GO:0048545 response to steroid hormone GO:0051384 response to glucocorticoid GO:0060759 regulation of response to cytokine stimulus GO:0060761 negative regulation of response to cytokine stimulus GO:0070498 interleukin-1-mediated signaling pathway GO:0070555 response to interleukin-1 GO:0070586 cell-cell adhesion involved in gastrulation GO:0070587 regulation of cell-cell adhesion involved in gastrulation GO:0071347 cellular response to interleukin-1 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:2000659 regulation of interleukin-1-mediated signaling pathway GO:2000660 negative regulation of interleukin-1-mediated signaling pathway
Molecular Function	GO:0005125 cytokine activity GO:0005126 cytokine receptor binding GO:0005149 interleukin-1 receptor binding GO:0005150 interleukin-1, Type I receptor binding GO:0005151 interleukin-1, Type II receptor binding GO:0005152 interleukin-1 receptor antagonist activity GO:0019838 growth factor binding GO:0019955 cytokine binding GO:0019966 interleukin-1 binding GO:0030545 receptor regulator activity GO:0030547 receptor inhibitor activity GO:0045352 interleukin-1 Type I receptor antagonist activity GO:0045353 interleukin-1 Type II receptor antagonist activity GO:0048019 receptor antagonist activity GO:0070851 growth factor receptor binding
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	-
Reactome	R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-168256: Immune System R-HSA-446652: Interleukin-1 signaling R-HSA-6783783: Interleukin-10 signaling R-HSA-449147: Signaling by Interleukins

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between IL1RN and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining

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Literatures describing the relation between IL1RN and anti-tumor immunity in human cancer.

PMID	Cancer type	Relation to immunity	Evidence sentences
17942936	Breast Carcinoma	Promote immunity (T cell function)	In contrast, excessive inflammation in IL-1R antagonist-deficient mice promotes the accumulation of MDSC and produces MDSC with enhanced suppressive activity.

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of IL1RN in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of IL1RN in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.299	0.652
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.835	0.585
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	0.112	0.911
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-1.279	0.093
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-2.192	0.207
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.134	0.946
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.121	0.851
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.566	0.639
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.362	0.783
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.25	0.853
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	-1.575	0.41
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.153	0.455

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of IL1RN in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	5.9	-5.9	0.447
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	9.1	-9.1	0.458
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	0	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	0	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	1

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of IL1RN. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of IL1RN. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by IL1RN. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of IL1RN. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of IL1RN expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between IL1RN and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	IL1RN
Name	interleukin 1 receptor antagonist
Aliases	ICIL-1RA; IL1F3; IL-1RN; MGC10430; interleukin-1 receptor antagonist protein; intracellular interleukin-1 re ......
Chromosomal Location	2q14.2
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting IL1RN collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting IL1RN.

ID	Name	Drug Type	Targets	#Targets
DB06372	Rilonacept	Biotech	IL1A, IL1B, IL1RN	3

Browse IL1RN