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Browse HOXA11

Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus.
Domain PF12045 Protein of unknown function (DUF3528)
PF00046 Homeobox domain
Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

> Gene Ontology
 
Biological Process GO:0001501 skeletal system development
GO:0001655 urogenital system development
GO:0001656 metanephros development
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001704 formation of primary germ layer
GO:0001707 mesoderm formation
GO:0001708 cell fate specification
GO:0001710 mesodermal cell fate commitment
GO:0001759 organ induction
GO:0001763 morphogenesis of a branching structure
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002062 chondrocyte differentiation
GO:0003002 regionalization
GO:0003156 regulation of animal organ formation
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0007369 gastrulation
GO:0007389 pattern specification process
GO:0007498 mesoderm development
GO:0007501 mesodermal cell fate specification
GO:0007548 sex differentiation
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0009566 fertilization
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0010092 specification of animal organ identity
GO:0010720 positive regulation of cell development
GO:0030326 embryonic limb morphogenesis
GO:0031128 developmental induction
GO:0032330 regulation of chondrocyte differentiation
GO:0032332 positive regulation of chondrocyte differentiation
GO:0035107 appendage morphogenesis
GO:0035108 limb morphogenesis
GO:0035113 embryonic appendage morphogenesis
GO:0035115 embryonic forelimb morphogenesis
GO:0035136 forelimb morphogenesis
GO:0035239 tube morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0045137 development of primary sexual characteristics
GO:0045165 cell fate commitment
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0048232 male gamete generation
GO:0048332 mesoderm morphogenesis
GO:0048333 mesodermal cell differentiation
GO:0048562 embryonic organ morphogenesis
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048645 animal organ formation
GO:0048704 embryonic skeletal system morphogenesis
GO:0048705 skeletal system morphogenesis
GO:0048706 embryonic skeletal system development
GO:0048736 appendage development
GO:0048754 branching morphogenesis of an epithelial tube
GO:0051216 cartilage development
GO:0060065 uterus development
GO:0060173 limb development
GO:0060272 embryonic skeletal joint morphogenesis
GO:0060348 bone development
GO:0060349 bone morphogenesis
GO:0060350 endochondral bone morphogenesis
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0060562 epithelial tube morphogenesis
GO:0060675 ureteric bud morphogenesis
GO:0060795 cell fate commitment involved in formation of primary germ layer
GO:0060993 kidney morphogenesis
GO:0061035 regulation of cartilage development
GO:0061036 positive regulation of cartilage development
GO:0061138 morphogenesis of a branching epithelium
GO:0061326 renal tubule development
GO:0061333 renal tubule morphogenesis
GO:0061448 connective tissue development
GO:0061458 reproductive system development
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072009 nephron epithelium development
GO:0072028 nephron morphogenesis
GO:0072073 kidney epithelium development
GO:0072078 nephron tubule morphogenesis
GO:0072080 nephron tubule development
GO:0072088 nephron epithelium morphogenesis
GO:0072163 mesonephric epithelium development
GO:0072164 mesonephric tubule development
GO:0072171 mesonephric tubule morphogenesis
GO:0072498 embryonic skeletal joint development
GO:2000027 regulation of organ morphogenesis
Molecular Function -
Cellular Component GO:0005667 transcription factor complex
GO:0032993 protein-DNA complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between HOXA11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of HOXA11 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of HOXA11 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.2160.0167
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.8820.0493
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7370.395
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3020.474
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1130.93
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5390.724
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.760.236
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.110.283
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2140.833
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.4270.619
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2610.815
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1470.45
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of HOXA11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of HOXA11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by HOXA11.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of HOXA11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of HOXA11 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between HOXA11 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolHOXA11
Namehomeobox A11
Aliases HOX1I; homeo box A11; homeo box 1I; homeobox protein HOXA11; homeobox protein Hox-1I; Homeobox protein Hox-A ......
Chromosomal Location7p15.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting HOXA11 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.