[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse GRM7

Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane; Multi-pass membrane protein.
Domain PF00003 7 transmembrane sweet-taste receptor of 3 GCPR
PF01094 Receptor family ligand binding region
PF07562 Nine Cysteines Domain of family 3 GPCR
Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

> Gene Ontology
 
Biological Process GO:0001661 conditioned taste aversion
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0006816 calcium ion transport
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007215 glutamate receptor signaling pathway
GO:0007216 G-protein coupled glutamate receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007605 sensory perception of sound
GO:0007608 sensory perception of smell
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007614 short-term memory
GO:0007631 feeding behavior
GO:0008306 associative learning
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0014047 glutamate secretion
GO:0014048 regulation of glutamate secretion
GO:0014050 negative regulation of glutamate secretion
GO:0015711 organic anion transport
GO:0019226 transmission of nerve impulse
GO:0030534 adult behavior
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030800 negative regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030803 negative regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030809 negative regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030815 negative regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030818 negative regulation of cAMP biosynthetic process
GO:0031279 regulation of cyclase activity
GO:0035249 synaptic transmission, glutamatergic
GO:0035637 multicellular organismal signaling
GO:0043271 negative regulation of ion transport
GO:0044070 regulation of anion transport
GO:0044708 single-organism behavior
GO:0045980 negative regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046390 ribose phosphate biosynthetic process
GO:0046942 carboxylic acid transport
GO:0050804 modulation of synaptic transmission
GO:0050890 cognition
GO:0050954 sensory perception of mechanical stimulus
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0052652 cyclic purine nucleotide metabolic process
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:0072522 purine-containing compound biosynthetic process
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900372 negative regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900543 negative regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1903531 negative regulation of secretion by cell
GO:1903792 negative regulation of anion transport
Molecular Function GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity
GO:0001642 group III metabotropic glutamate receptor activity
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005246 calcium channel regulator activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0008066 glutamate receptor activity
GO:0010851 cyclase regulator activity
GO:0010854 adenylate cyclase regulator activity
GO:0010855 adenylate cyclase inhibitor activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0016247 channel regulator activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0043177 organic acid binding
GO:0046873 metal ion transmembrane transporter activity
GO:0070905 serine binding
GO:0072509 divalent inorganic cation transmembrane transporter activity
GO:0098988 G-protein coupled glutamate receptor activity
Cellular Component GO:0005938 cell cortex
GO:0030424 axon
GO:0030425 dendrite
GO:0032279 asymmetric synapse
GO:0042734 presynaptic membrane
GO:0043198 dendritic shaft
GO:0043235 receptor complex
GO:0045211 postsynaptic membrane
GO:0048786 presynaptic active zone
GO:0097060 synaptic membrane
GO:0098793 presynapse
GO:0098794 postsynapse
GO:0098984 neuron to neuron synapse
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04724 Glutamatergic synapse
Reactome R-HSA-420499: Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594: G alpha (i) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GRM7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GRM7 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GRM7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1140.809
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.4310.718
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.290.83
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.9740.208
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-1.3390.344
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.6010.694
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.5880.421
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.5880.554
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7690.00576
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GRM7 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.15.55.60.384
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.16.84.30.673
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211738.111.826.30.136
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131138.518.220.30.386
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.97.40.51
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.17.71.41
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GRM7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GRM7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GRM7.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GRM7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GRM7 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GRM7 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGRM7
Nameglutamate receptor, metabotropic 7
Aliases GPRC1G; mGlu7; MGLUR7; PPP1R87; protein phosphatase 1, regulatory subunit 87; Metabotropic glutamate recepto ......
Chromosomal Location3p26-p25
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GRM7 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting GRM7.
ID Name Drug Type Targets #Targets
DB00142Glutamic AcidSmall MoleculeAADAT, AASS, ABAT, ALDH18A1, ASNS, BCAT1, BCAT2, CCBL2, CPQ, DNPEP ......69