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Browse GLI1

Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Nucleus Note=Tethered in the cytoplasm by binding to SUFU (PubMed:10806483). Activation and translocation to the nucleus is promoted by interaction with STK36 (PubMed:10806483). Phosphorylation by ULK3 may promote nuclear localization (PubMed:19878745). Translocation to the nucleus is promoted by interaction with ZIC1 (PubMed:11238441). ; SUBCELLULAR LOCATION: Isoform 2: Cytoplasm Nucleus
Domain -
Function

Acts as a transcriptional activator (PubMed:19706761, PubMed:10806483, PubMed:19878745, PubMed:24311597, PubMed:24217340). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:2105456, PubMed:8378770, PubMed:24217340). May regulate the transcription of specific genes during normal development (PubMed:19706761). May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling (PubMed:19706761). Plays a role in cell proliferation and differentiation via its role in SHH signaling (Probable). ; FUNCTION: Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.

> Gene Ontology
 
Biological Process GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0001889 liver development
GO:0003002 regionalization
GO:0006260 DNA replication
GO:0006275 regulation of DNA replication
GO:0007224 smoothened signaling pathway
GO:0007283 spermatogenesis
GO:0007389 pattern specification process
GO:0007418 ventral midline development
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009913 epidermal cell differentiation
GO:0009953 dorsal/ventral pattern formation
GO:0009954 proximal/distal pattern formation
GO:0016055 Wnt signaling pathway
GO:0021536 diencephalon development
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0021695 cerebellar cortex development
GO:0021696 cerebellar cortex morphogenesis
GO:0021936 regulation of cerebellar granule cell precursor proliferation
GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation
GO:0021938 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation
GO:0021940 positive regulation of cerebellar granule cell precursor proliferation
GO:0021983 pituitary gland development
GO:0022037 metencephalon development
GO:0022612 gland morphogenesis
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030278 regulation of ossification
GO:0030323 respiratory tube development
GO:0030324 lung development
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0030903 notochord development
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0035239 tube morphogenesis
GO:0035270 endocrine system development
GO:0045667 regulation of osteoblast differentiation
GO:0045740 positive regulation of DNA replication
GO:0045880 positive regulation of smoothened signaling pathway
GO:0048232 male gamete generation
GO:0048546 digestive tract morphogenesis
GO:0048562 embryonic organ morphogenesis
GO:0048565 digestive tract development
GO:0048568 embryonic organ development
GO:0048570 notochord morphogenesis
GO:0048732 gland development
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051962 positive regulation of nervous system development
GO:0055123 digestive system development
GO:0060032 notochord regression
GO:0060033 anatomical structure regression
GO:0060070 canonical Wnt signaling pathway
GO:0060541 respiratory system development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0061008 hepaticobiliary system development
GO:0072574 hepatocyte proliferation
GO:0072575 epithelial cell proliferation involved in liver morphogenesis
GO:0072576 liver morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0097421 liver regeneration
GO:0198738 cell-cell signaling by wnt
GO:2000027 regulation of organ morphogenesis
GO:2000177 regulation of neural precursor cell proliferation
GO:2000179 positive regulation of neural precursor cell proliferation
GO:2000345 regulation of hepatocyte proliferation
Molecular Function GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001159 core promoter proximal region DNA binding
GO:0003682 chromatin binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
Cellular Component GO:0005929 cilium
GO:0005930 axoneme
GO:0044441 ciliary part
GO:0072372 primary cilium
GO:0097014 ciliary plasm
GO:0097542 ciliary tip
GO:0097546 ciliary base
> KEGG and Reactome Pathway
 
KEGG hsa04024 cAMP signaling pathway
hsa04340 Hedgehog signaling pathway
Reactome R-HSA-5610780: Degradation of GLI1 by the proteasome
R-HSA-5635851: GLI proteins bind promoters of Hh responsive genes to promote transcription
R-HSA-5610787: Hedgehog 'off' state
R-HSA-5632684: Hedgehog 'on' state
R-HSA-162582: Signal Transduction
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GLI1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GLI1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GLI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.260.24
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2340.585
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.620.0817
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3470.443
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.2170.899
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.5060.824
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.9280.0656
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.1110.15
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.6590.412
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.530.572
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0370.975
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7520.00147
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GLI1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.19.61.51
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.110.20.91
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.57.7-3.21
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GLI1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GLI1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GLI1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GLI1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GLI1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GLI1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGLI1
NameGLI family zinc finger 1
Aliases GLI; glioma-associated oncogene homolog 1 (zinc finger protein); glioma-associated oncogene family zinc fing ......
Chromosomal Location12q13.2-q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GLI1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.