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Browse GAS6

Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted
Domain PF12662 Complement Clr-like EGF-like
PF07645 Calcium-binding EGF domain
PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
PF12661 Human growth factor-like EGF
PF00054 Laminin G domain
PF02210 Laminin G domain
Function

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. ; FUNCTION: (Microbial infection) Can bridges virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688).

> Gene Ontology
 
Biological Process GO:0000060 protein import into nucleus, translocation
GO:0001678 cellular glucose homeostasis
GO:0001764 neuron migration
GO:0001779 natural killer cell differentiation
GO:0001818 negative regulation of cytokine production
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0001977 renal system process involved in regulation of blood volume
GO:0002367 cytokine production involved in immune response
GO:0002407 dendritic cell chemotaxis
GO:0002440 production of molecular mediator of immune response
GO:0002521 leukocyte differentiation
GO:0002576 platelet degranulation
GO:0002685 regulation of leukocyte migration
GO:0002687 positive regulation of leukocyte migration
GO:0002688 regulation of leukocyte chemotaxis
GO:0002690 positive regulation of leukocyte chemotaxis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0003013 circulatory system process
GO:0003014 renal system process
GO:0003071 renal system process involved in regulation of systemic arterial blood pressure
GO:0003073 regulation of systemic arterial blood pressure
GO:0003093 regulation of glomerular filtration
GO:0003094 glomerular filtration
GO:0003104 positive regulation of glomerular filtration
GO:0006465 signal peptide processing
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006612 protein targeting to membrane
GO:0006816 calcium ion transport
GO:0006887 exocytosis
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0006909 phagocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007009 plasma membrane organization
GO:0007050 cell cycle arrest
GO:0007584 response to nutrient
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008217 regulation of blood pressure
GO:0009267 cellular response to starvation
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009991 response to extracellular stimulus
GO:0010466 negative regulation of peptidase activity
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0010934 macrophage cytokine production
GO:0010951 negative regulation of endopeptidase activity
GO:0016485 protein processing
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018212 peptidyl-tyrosine modification
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019079 viral genome replication
GO:0030098 lymphocyte differentiation
GO:0030100 regulation of endocytosis
GO:0030101 natural killer cell activation
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0030260 entry into host cell
GO:0030335 positive regulation of cell migration
GO:0030595 leukocyte chemotaxis
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031214 biomineral tissue development
GO:0031589 cell-substrate adhesion
GO:0031667 response to nutrient levels
GO:0031668 cellular response to extracellular stimulus
GO:0031669 cellular response to nutrient levels
GO:0031670 cellular response to nutrient
GO:0031929 TOR signaling
GO:0032006 regulation of TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032103 positive regulation of response to external stimulus
GO:0032147 activation of protein kinase activity
GO:0032148 activation of protein kinase B activity
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032571 response to vitamin K
GO:0032609 interferon-gamma production
GO:0032612 interleukin-1 production
GO:0032635 interleukin-6 production
GO:0032640 tumor necrosis factor production
GO:0032649 regulation of interferon-gamma production
GO:0032652 regulation of interleukin-1 production
GO:0032675 regulation of interleukin-6 production
GO:0032680 regulation of tumor necrosis factor production
GO:0032689 negative regulation of interferon-gamma production
GO:0032692 negative regulation of interleukin-1 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032814 regulation of natural killer cell activation
GO:0032816 positive regulation of natural killer cell activation
GO:0032823 regulation of natural killer cell differentiation
GO:0032825 positive regulation of natural killer cell differentiation
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033157 regulation of intracellular protein transport
GO:0033158 regulation of protein import into nucleus, translocation
GO:0033159 negative regulation of protein import into nucleus, translocation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033273 response to vitamin
GO:0033500 carbohydrate homeostasis
GO:0033674 positive regulation of kinase activity
GO:0034109 homotypic cell-cell adhesion
GO:0034284 response to monosaccharide
GO:0034349 glial cell apoptotic process
GO:0034350 regulation of glial cell apoptotic process
GO:0034351 negative regulation of glial cell apoptotic process
GO:0034504 protein localization to nucleus
GO:0034612 response to tumor necrosis factor
GO:0035455 response to interferon-alpha
GO:0035457 cellular response to interferon-alpha
GO:0035690 cellular response to drug
GO:0035701 hematopoietic stem cell migration
GO:0035754 B cell chemotaxis
GO:0036336 dendritic cell migration
GO:0039663 membrane fusion involved in viral entry into host cell
GO:0040017 positive regulation of locomotion
GO:0042306 regulation of protein import into nucleus
GO:0042308 negative regulation of protein import into nucleus
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0043062 extracellular structure organization
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043491 protein kinase B signaling
GO:0044057 regulation of system process
GO:0044346 fibroblast apoptotic process
GO:0044406 adhesion of symbiont to host
GO:0044409 entry into host
GO:0044650 adhesion of symbiont to host cell
GO:0044744 protein targeting to nucleus
GO:0044800 multi-organism membrane fusion
GO:0044803 multi-organism membrane organization
GO:0045055 regulated exocytosis
GO:0045619 regulation of lymphocyte differentiation
GO:0045621 positive regulation of lymphocyte differentiation
GO:0045786 negative regulation of cell cycle
GO:0045807 positive regulation of endocytosis
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0046825 regulation of protein export from nucleus
GO:0046827 positive regulation of protein export from nucleus
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048193 Golgi vesicle transport
GO:0048247 lymphocyte chemotaxis
GO:0050663 cytokine secretion
GO:0050701 interleukin-1 secretion
GO:0050704 regulation of interleukin-1 secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050709 negative regulation of protein secretion
GO:0050710 negative regulation of cytokine secretion
GO:0050711 negative regulation of interleukin-1 secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050764 regulation of phagocytosis
GO:0050766 positive regulation of phagocytosis
GO:0050817 coagulation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050878 regulation of body fluid levels
GO:0050900 leukocyte migration
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0051048 negative regulation of secretion
GO:0051051 negative regulation of transport
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051224 negative regulation of protein transport
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051272 positive regulation of cellular component movement
GO:0051346 negative regulation of hydrolase activity
GO:0051604 protein maturation
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060326 cell chemotaxis
GO:0060627 regulation of vesicle-mediated transport
GO:0060759 regulation of response to cytokine stimulus
GO:0060760 positive regulation of response to cytokine stimulus
GO:0060761 negative regulation of response to cytokine stimulus
GO:0061025 membrane fusion
GO:0061082 myeloid leukocyte cytokine production
GO:0061097 regulation of protein tyrosine kinase activity
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070167 regulation of biomineral tissue development
GO:0070168 negative regulation of biomineral tissue development
GO:0070293 renal absorption
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071295 cellular response to vitamin
GO:0071307 cellular response to vitamin K
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071496 cellular response to external stimulus
GO:0071706 tumor necrosis factor superfamily cytokine production
GO:0071887 leukocyte apoptotic process
GO:0072511 divalent inorganic cation transport
GO:0072577 endothelial cell apoptotic process
GO:0072604 interleukin-6 secretion
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0072661 protein targeting to plasma membrane
GO:0072676 lymphocyte migration
GO:0085029 extracellular matrix assembly
GO:0090002 establishment of protein localization to plasma membrane
GO:0090150 establishment of protein localization to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0090317 negative regulation of intracellular protein transport
GO:0097017 renal protein absorption
GO:0097018 renal albumin absorption
GO:0097028 dendritic cell differentiation
GO:0097048 dendritic cell apoptotic process
GO:0097205 renal filtration
GO:0097241 hematopoietic stem cell migration to bone marrow
GO:0097252 oligodendrocyte apoptotic process
GO:0098801 regulation of renal system process
GO:1900141 regulation of oligodendrocyte apoptotic process
GO:1900142 negative regulation of oligodendrocyte apoptotic process
GO:1900165 negative regulation of interleukin-6 secretion
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902593 single-organism nuclear import
GO:1903531 negative regulation of secretion by cell
GO:1903533 regulation of protein targeting
GO:1903555 regulation of tumor necrosis factor superfamily cytokine production
GO:1903556 negative regulation of tumor necrosis factor superfamily cytokine production
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903828 negative regulation of cellular protein localization
GO:1903829 positive regulation of cellular protein localization
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904589 regulation of protein import
GO:1904590 negative regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:1990778 protein localization to cell periphery
GO:2000106 regulation of leukocyte apoptotic process
GO:2000107 negative regulation of leukocyte apoptotic process
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000147 positive regulation of cell motility
GO:2000269 regulation of fibroblast apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000508 regulation of dendritic cell chemotaxis
GO:2000510 positive regulation of dendritic cell chemotaxis
GO:2000532 regulation of renal albumin absorption
GO:2000533 negative regulation of renal albumin absorption
GO:2000668 regulation of dendritic cell apoptotic process
GO:2000669 negative regulation of dendritic cell apoptotic process
Molecular Function GO:0001786 phosphatidylserine binding
GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005543 phospholipid binding
GO:0008047 enzyme activator activity
GO:0015085 calcium ion transmembrane transporter activity
GO:0015267 channel activity
GO:0019207 kinase regulator activity
GO:0019209 kinase activator activity
GO:0019887 protein kinase regulator activity
GO:0022803 passive transmembrane transporter activity
GO:0022832 voltage-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022843 voltage-gated cation channel activity
GO:0030295 protein kinase activator activity
GO:0030296 protein tyrosine kinase activator activity
GO:0030414 peptidase inhibitor activity
GO:0030545 receptor regulator activity
GO:0030546 receptor activator activity
GO:0030971 receptor tyrosine kinase binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process
GO:0046873 metal ion transmembrane transporter activity
GO:0048018 receptor agonist activity
GO:0060090 binding, bridging
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
GO:0072341 modified amino acid binding
GO:0072509 divalent inorganic cation transmembrane transporter activity
GO:1990782 protein tyrosine kinase binding
Cellular Component GO:0005788 endoplasmic reticulum lumen
GO:0005796 Golgi lumen
GO:0030141 secretory granule
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0031983 vesicle lumen
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic membrane-bounded vesicle lumen
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-163841: Gamma carboxylation, hypusine formation and arylsulfatase activation
R-HSA-159740: Gamma-carboxylation of protein precursors
R-HSA-159854: Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
R-HSA-109582: Hemostasis
R-HSA-392499: Metabolism of proteins
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-597592: Post-translational protein modification
R-HSA-159782: Removal of aminoterminal propeptides from gamma-carboxylated proteins
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-HSA-159763: Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GAS6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GAS6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GAS6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.950.0187
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.2930.55
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.7050.678
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3440.485
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.6040.833
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.010.998
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0720.857
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.4970.716
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.7770.629
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.310.507
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.2140.425
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3360.0548
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of GAS6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277304.1-4.10.561
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GAS6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GAS6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GAS6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GAS6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GAS6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GAS6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGAS6
Namegrowth arrest-specific 6
Aliases AXSF; FLJ34709; DKFZp666G247; AXL stimulatory factor; AXLLG; AXL receptor tyrosine kinase ligand; GAS-6; Gro ......
Chromosomal Location13q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GAS6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.