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Browse GADD45B

Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF01248 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Function

Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

> Gene Ontology
 
Biological Process GO:0000185 activation of MAPKKK activity
GO:0000186 activation of MAPKK activity
GO:0001933 negative regulation of protein phosphorylation
GO:0006469 negative regulation of protein kinase activity
GO:0007254 JNK cascade
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032147 activation of protein kinase activity
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032874 positive regulation of stress-activated MAPK cascade
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0038066 p38MAPK cascade
GO:0042326 negative regulation of phosphorylation
GO:0043405 regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045860 positive regulation of protein kinase activity
GO:0046328 regulation of JNK cascade
GO:0046330 positive regulation of JNK cascade
GO:0051348 negative regulation of transferase activity
GO:0051403 stress-activated MAPK cascade
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070304 positive regulation of stress-activated protein kinase signaling cascade
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:1900744 regulation of p38MAPK cascade
GO:1900745 positive regulation of p38MAPK cascade
Molecular Function -
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04064 NF-kappa B signaling pathway
hsa04068 FoxO signaling pathway
hsa04110 Cell cycle
hsa04115 p53 signaling pathway
hsa04210 Apoptosis
Reactome -
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between GADD45B and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between GADD45B and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
29279355Hepatocellular carcinoma, ovarian adenocarcinomaInhibit immunity (infiltration); immunotherapy targetIn various models of solid cancers refractory to immunotherapies, including hepatocellular carcinoma and ovarian adenocarcinoma, Gadd45b inhibition in myeloid cells restored activation of proinflammatory tumor-associated macrophages (TAM) and intratumoral immune infiltration, thereby diminishing oncogenesis.
19688743MelanomaInhibit immunityGadd45b, a signaling molecule highly up-regulated during Th1 type responses, is studied for its role in limiting tumor growth. Mouse B16 melanoma cells implanted into Gadd45b(-/-) mice grew faster than those in WT or Gadd45b(+/-) littermate controls. The defect of Gadd45b(-/-) mice in tumor immunosurveillance was attributed to the reduced expression of IFN-gamma, granzyme B, and CCR5 in Gadd45b(-/-) CD8(+) T cells at the tumor site.
16826163lymphomaInhibit immunityThese results demonstrated that this immunization may activate T cells in vivo. Furthermore, the splenocytes from immunized mice revealed resistance to activation-induced cell death (AICD) in vitro. To further study the relative genes that are responsible for the higher proliferation and resistance to AICD, the expression of Fas/Fas ligand (FasL) and GADD45b was measured by real-time PCR. The results indicated that GADD45beta transcription was higher in the splenocytes from immunized mice than that in the naive mice. In addition, the Fas expression showed a parallel higher, but FasL did not change obviously.
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of GADD45B in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of GADD45B in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.7240.0832
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.110.604
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.4350.769
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2220.764
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.2740.485
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1130.647
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0150.97
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1710.887
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2720.845
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3610.838
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.0010.7
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1480.329
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of GADD45B. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of GADD45B. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by GADD45B.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of GADD45B. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of GADD45B expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between GADD45B and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolGADD45B
Namegrowth arrest and DNA-damage-inducible, beta
Aliases GADD45BETA; DKFZP566B133; myeloid differentiation primary response; growth arrest and DNA-damage-inducible b ......
Chromosomal Location19p13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting GADD45B collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.