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Browse G6PC

Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Domain PF01569 PAP2 superfamily
Function

Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.

> Gene Ontology
 
Biological Process GO:0000272 polysaccharide catabolic process
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006094 gluconeogenesis
GO:0006112 energy reserve metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0008202 steroid metabolic process
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009251 glucan catabolic process
GO:0009991 response to extracellular stimulus
GO:0015712 hexose phosphate transport
GO:0015748 organophosphate ester transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015760 glucose-6-phosphate transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016051 carbohydrate biosynthetic process
GO:0016052 carbohydrate catabolic process
GO:0016311 dephosphorylation
GO:0019318 hexose metabolic process
GO:0019319 hexose biosynthetic process
GO:0031667 response to nutrient levels
GO:0032094 response to food
GO:0033500 carbohydrate homeostasis
GO:0035264 multicellular organism growth
GO:0042593 glucose homeostasis
GO:0042632 cholesterol homeostasis
GO:0044042 glucan metabolic process
GO:0044247 cellular polysaccharide catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044275 cellular carbohydrate catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0046364 monosaccharide biosynthetic process
GO:0046415 urate metabolic process
GO:0046486 glycerolipid metabolic process
GO:0046838 phosphorylated carbohydrate dephosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0055088 lipid homeostasis
GO:0055092 sterol homeostasis
GO:1901264 carbohydrate derivative transport
Molecular Function GO:0004346 glucose-6-phosphatase activity
GO:0016791 phosphatase activity
GO:0019203 carbohydrate phosphatase activity
GO:0042301 phosphate ion binding
GO:0042578 phosphoric ester hydrolase activity
GO:0043168 anion binding
GO:0050308 sugar-phosphatase activity
GO:0050309 sugar-terminal-phosphatase activity
Cellular Component GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031227 intrinsic component of endoplasmic reticulum membrane
> KEGG and Reactome Pathway
 
KEGG hsa04068 FoxO signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04910 Insulin signaling pathway
hsa04920 Adipocytokine signaling pathway
hsa04922 Glucagon signaling pathway
hsa04973 Carbohydrate digestion and absorption
hsa00010 Glycolysis / Gluconeogenesis
hsa00052 Galactose metabolism
hsa00500 Starch and sucrose metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-70153: Glucose transport
R-HSA-189200: Hexose transport
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-425407: SLC-mediated transmembrane transport
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between G6PC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of G6PC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of G6PC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.6870.242
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)871.2030.158
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.9220.233
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.7030.57
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1850.366
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.9160.338
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2470.517
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2690.882
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1520.898
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2230.42
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.6890.0377
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of G6PC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of G6PC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of G6PC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by G6PC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of G6PC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of G6PC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between G6PC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolG6PC
Nameglucose-6-phosphatase, catalytic subunit
Aliases GSD1a; glycogen storage disease type I, von Gierke disease; G6PT; glucose-6-phosphatase, catalytic (glycogen ......
Chromosomal Location17q21
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting G6PC collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.