TISIDB

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane Multi-pass membrane protein Cell surface Apical cell membrane Multi-pass membrane protein. Note=Colocalizes with FZD6 at the apical face of the cell (By similarity).
Domain	PF01534 Frizzled/Smoothened family membrane region PF01392 Fz domain
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Required for the development of major fiber tracts in the central nervous system, including: the anterior commissure, the corpus callosum, the thalamocortical, corticothalamic and nigrostriatal tracts, the corticospinal tract, the fasciculus retroflexus, the mammillothalamic tract, the medial lemniscus, and ascending fiber tracts from the spinal cord to the brain. In the peripheral nervous system, controls axon growth in distinct populations of cranial and spinal motor neurons, including the facial branchimotor nerve, the hypoglossal nerve, the phrenic nerve, and motor nerves innervating dorsal limbs. Involved in the migration of cranial neural crest cells. May also be implicated in the transmission of sensory information from the trunk and limbs to the brain. Controls commissural sensory axons guidance after midline crossing along the anterior-posterior axis in the developing spinal cord in a Wnt-dependent signaling pathway. Together with FZD6, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle in a beta-catenin-dependent manner (By similarity).

> Gene Ontology [ TOP ]
Biological Process	GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001764 neuron migration GO:0001838 embryonic epithelial tube formation GO:0001841 neural tube formation GO:0001843 neural tube closure GO:0001942 hair follicle development GO:0002052 positive regulation of neuroblast proliferation GO:0007164 establishment of tissue polarity GO:0007223 Wnt signaling pathway, calcium modulating pathway GO:0007346 regulation of mitotic cell cycle GO:0007405 neuroblast proliferation GO:0007409 axonogenesis GO:0007411 axon guidance GO:0007423 sensory organ development GO:0008544 epidermis development GO:0009794 regulation of mitotic cell cycle, embryonic GO:0010720 positive regulation of cell development GO:0014020 primary neural tube formation GO:0016055 Wnt signaling pathway GO:0016331 morphogenesis of embryonic epithelium GO:0021915 neural tube development GO:0022404 molting cycle process GO:0022405 hair cycle process GO:0030901 midbrain development GO:0033278 cell proliferation in midbrain GO:0035148 tube formation GO:0035239 tube morphogenesis GO:0035567 non-canonical Wnt signaling pathway GO:0036342 post-anal tail morphogenesis GO:0036514 dopaminergic neuron axon guidance GO:0036515 serotonergic neuron axon guidance GO:0042303 molting cycle GO:0042471 ear morphogenesis GO:0042472 inner ear morphogenesis GO:0042493 response to drug GO:0042633 hair cycle GO:0043583 ear development GO:0043588 skin development GO:0045448 mitotic cell cycle, embryonic GO:0045786 negative regulation of cell cycle GO:0045930 negative regulation of mitotic cell cycle GO:0045976 negative regulation of mitotic cell cycle, embryonic GO:0045992 negative regulation of embryonic development GO:0045995 regulation of embryonic development GO:0048483 autonomic nervous system development GO:0048485 sympathetic nervous system development GO:0048562 embryonic organ morphogenesis GO:0048568 embryonic organ development GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048839 inner ear development GO:0048854 brain morphogenesis GO:0050769 positive regulation of neurogenesis GO:0051602 response to electrical stimulus GO:0051962 positive regulation of nervous system development GO:0060070 canonical Wnt signaling pathway GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060562 epithelial tube morphogenesis GO:0060606 tube closure GO:0061351 neural precursor cell proliferation GO:0061548 ganglion development GO:0061549 sympathetic ganglion development GO:0061564 axon development GO:0071679 commissural neuron axon guidance GO:0072089 stem cell proliferation GO:0072091 regulation of stem cell proliferation GO:0072175 epithelial tube formation GO:0090175 regulation of establishment of planar polarity GO:0090596 sensory organ morphogenesis GO:0097194 execution phase of apoptosis GO:0097485 neuron projection guidance GO:0098773 skin epidermis development GO:0198738 cell-cell signaling by wnt GO:1900117 regulation of execution phase of apoptosis GO:1900118 negative regulation of execution phase of apoptosis GO:1902692 regulation of neuroblast proliferation GO:1904693 midbrain morphogenesis GO:1904938 planar cell polarity pathway involved in axon guidance GO:1905330 regulation of morphogenesis of an epithelium GO:2000027 regulation of organ morphogenesis GO:2000177 regulation of neural precursor cell proliferation GO:2000179 positive regulation of neural precursor cell proliferation GO:2000648 positive regulation of stem cell proliferation
Molecular Function	GO:0017147 Wnt-protein binding GO:0030165 PDZ domain binding GO:0042813 Wnt-activated receptor activity
Cellular Component	GO:0016324 apical plasma membrane GO:0016328 lateral plasma membrane GO:0030175 filopodium GO:0030424 axon GO:0030425 dendrite GO:0032433 filopodium tip GO:0043025 neuronal cell body GO:0044297 cell body GO:0045177 apical part of cell GO:0048786 presynaptic active zone GO:0098793 presynapse GO:0098858 actin-based cell projection

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa04150 mTOR signaling pathway hsa04310 Wnt signaling pathway hsa04360 Axon guidance hsa04390 Hippo signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04916 Melanogenesis
Reactome	R-HSA-4608870: Asymmetric localization of PCP proteins R-HSA-3858494: Beta-catenin independent WNT signaling R-HSA-4086398: Ca2+ pathway R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-500792: GPCR ligand binding R-HSA-4086400: PCP/CE pathway R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-195721: Signaling by Wnt

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between FZD3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

[ TOP ]

Statistical results of FZD3 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA	Resistant to T cell-mediated killing
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of FZD3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.053	0.833
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	0.14	0.837
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.198	0.732
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.261	0.504
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0.002	0.999
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.593	0.751
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.13	0.753
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	-0.478	0.728
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	0.302	0.835
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.108	0.85
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.252	0.736
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.05	0.725

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of FZD3 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	0	0	0	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	0	0	0	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	4.8	0	4.8	1
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	0	7.7	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	0	3.7	-3.7	0.415
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	0	7.7	-7.7	0.371
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	0	0	0	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FZD3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FZD3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FZD3. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FZD3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of FZD3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between FZD3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	FZD3
Name	frizzled class receptor 3
Aliases	frizzled (Drosophila) homolog 3; frizzled homolog 3 (Drosophila); frizzled 3, seven transmembrane spanning r ......
Chromosomal Location	8p21
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting FZD3 collected from DrugBank database.

> Drugs from DrugBank database [ TOP ]
There is no record.

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