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Browse FLNA

Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cell cortex. Cytoplasm, cytoskeleton.
Domain PF00307 Calponin homology (CH) domain
PF00630 Filamin/ABP280 repeat
Function

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity).

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0002011 morphogenesis of an epithelial sheet
GO:0002576 platelet degranulation
GO:0006356 regulation of transcription from RNA polymerase I promoter
GO:0006360 transcription from RNA polymerase I promoter
GO:0006606 protein import into nucleus
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007015 actin filament organization
GO:0007051 spindle organization
GO:0007067 mitotic nuclear division
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0009299 mRNA transcription
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010770 positive regulation of cell morphogenesis involved in differentiation
GO:0010810 regulation of cell-substrate adhesion
GO:0010811 positive regulation of cell-substrate adhesion
GO:0010927 cellular component assembly involved in morphogenesis
GO:0016479 negative regulation of transcription from RNA polymerase I promoter
GO:0017038 protein import
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0030168 platelet activation
GO:0031532 actin cytoskeleton reorganization
GO:0031589 cell-substrate adhesion
GO:0031647 regulation of protein stability
GO:0032386 regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032507 maintenance of protein location in cell
GO:0033157 regulation of intracellular protein transport
GO:0034109 homotypic cell-cell adhesion
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034394 protein localization to cell surface
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034504 protein localization to nucleus
GO:0042176 regulation of protein catabolic process
GO:0042177 negative regulation of protein catabolic process
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042384 cilium assembly
GO:0042789 mRNA transcription from RNA polymerase II promoter
GO:0042990 regulation of transcription factor import into nucleus
GO:0042991 transcription factor import into nucleus
GO:0042993 positive regulation of transcription factor import into nucleus
GO:0043113 receptor clustering
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044319 wound healing, spreading of cells
GO:0044744 protein targeting to nucleus
GO:0044782 cilium organization
GO:0045055 regulated exocytosis
GO:0045185 maintenance of protein location
GO:0045785 positive regulation of cell adhesion
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046824 positive regulation of nucleocytoplasmic transport
GO:0050817 coagulation
GO:0050821 protein stabilization
GO:0050878 regulation of body fluid levels
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051220 cytoplasmic sequestering of protein
GO:0051222 positive regulation of protein transport
GO:0051225 spindle assembly
GO:0051235 maintenance of location
GO:0051651 maintenance of location in cell
GO:0051668 localization within membrane
GO:0051764 actin crosslink formation
GO:0060271 cilium morphogenesis
GO:0070527 platelet aggregation
GO:0071526 semaphorin-plexin signaling pathway
GO:0072657 protein localization to membrane
GO:0090307 mitotic spindle assembly
GO:0090316 positive regulation of intracellular protein transport
GO:0090504 epiboly
GO:0090505 epiboly involved in wound healing
GO:1900024 regulation of substrate adhesion-dependent cell spreading
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1902593 single-organism nuclear import
GO:1902850 microtubule cytoskeleton organization involved in mitosis
GO:1903533 regulation of protein targeting
GO:1903829 positive regulation of cellular protein localization
GO:1904589 regulation of protein import
GO:1904591 positive regulation of protein import
GO:1904951 positive regulation of establishment of protein localization
GO:2001044 regulation of integrin-mediated signaling pathway
GO:2001046 positive regulation of integrin-mediated signaling pathway
Molecular Function GO:0001664 G-protein coupled receptor binding
GO:0001948 glycoprotein binding
GO:0003779 actin binding
GO:0008134 transcription factor binding
GO:0017016 Ras GTPase binding
GO:0017048 Rho GTPase binding
GO:0017160 Ral GTPase binding
GO:0031267 small GTPase binding
GO:0031628 opioid receptor binding
GO:0031852 mu-type opioid receptor binding
GO:0034987 immunoglobulin receptor binding
GO:0034988 Fc-gamma receptor I complex binding
GO:0045296 cadherin binding
GO:0046332 SMAD binding
GO:0048365 Rac GTPase binding
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0051020 GTPase binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0005884 actin filament
GO:0005913 cell-cell adherens junction
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0015629 actin cytoskeleton
GO:0030055 cell-substrate junction
GO:0030425 dendrite
GO:0030863 cortical cytoskeleton
GO:0031523 Myb complex
GO:0031941 filamentous actin
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0044297 cell body
GO:0044448 cell cortex part
GO:0097440 apical dendrite
GO:0099568 cytoplasmic region
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04510 Focal adhesion
Reactome R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-446353: Cell-extracellular matrix interactions
R-HSA-430116: GP1b-IX-V activation signalling
R-HSA-109582: Hemostasis
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-114608: Platelet degranulation
R-HSA-195258: RHO GTPase Effectors
R-HSA-5627123: RHO GTPases activate PAKs
R-HSA-76005: Response to elevated platelet cytosolic Ca2+
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between FLNA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of FLNA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of FLNA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0060.985
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3180.924
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.2180.927
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.5460.429
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.470.911
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.6430.905
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2270.698
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0530.983
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.430.876
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1810.684
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.5620.722
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.3290.0232
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of FLNA in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277314.81.413.40.0181
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275914.81.713.10.032
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382713.23.79.50.388
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.57.15.41
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of FLNA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of FLNA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by FLNA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of FLNA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of FLNA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between FLNA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolFLNA
Namefilamin A, alpha
Aliases FLN1; FLN; OPD2; OPD1; filamin A, alpha (actin binding protein 280); ABPX; CVD1; FLN-A; NHBP; OPD; XLVD; XMV ......
Chromosomal LocationXq28
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting FLNA collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting FLNA.
ID Name Drug Type Targets #Targets
DB11638ArtenimolSmall MoleculeACTG1, ALB, ALDH7A1, ALDOA, ANXA2, ATP5A1, ATP5L, ATP5O, CAST, CCT ......79