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Browse DRD1

Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14.
Domain PF00001 7 transmembrane receptor (rhodopsin family)
Function

Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.

> Gene Ontology
 
Biological Process GO:0001504 neurotransmitter uptake
GO:0001505 regulation of neurotransmitter levels
GO:0001508 action potential
GO:0001659 temperature homeostasis
GO:0001661 conditioned taste aversion
GO:0001662 behavioral fear response
GO:0001764 neuron migration
GO:0001963 synaptic transmission, dopaminergic
GO:0001964 startle response
GO:0001975 response to amphetamine
GO:0002209 behavioral defense response
GO:0003012 muscle system process
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006140 regulation of nucleotide metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006171 cAMP biosynthetic process
GO:0006584 catecholamine metabolic process
GO:0006606 protein import into nucleus
GO:0006813 potassium ion transport
GO:0006816 calcium ion transport
GO:0006836 neurotransmitter transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006913 nucleocytoplasmic transport
GO:0006936 muscle contraction
GO:0006939 smooth muscle contraction
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190 activation of adenylate cyclase activity
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007212 dopamine receptor signaling pathway
GO:0007270 neuron-neuron synaptic transmission
GO:0007416 synapse assembly
GO:0007611 learning or memory
GO:0007612 learning
GO:0007613 memory
GO:0007617 mating behavior
GO:0007618 mating
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0007628 adult walking behavior
GO:0007631 feeding behavior
GO:0007632 visual behavior
GO:0008015 blood circulation
GO:0008306 associative learning
GO:0008344 adult locomotory behavior
GO:0008542 visual learning
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009150 purine ribonucleotide metabolic process
GO:0009152 purine ribonucleotide biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0009187 cyclic nucleotide metabolic process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0009260 ribonucleotide biosynthetic process
GO:0009308 amine metabolic process
GO:0009314 response to radiation
GO:0009416 response to light stimulus
GO:0009712 catechol-containing compound metabolic process
GO:0010001 glial cell differentiation
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0010959 regulation of metal ion transport
GO:0014002 astrocyte development
GO:0014075 response to amine
GO:0014821 phasic smooth muscle contraction
GO:0015672 monovalent inorganic cation transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015837 amine transport
GO:0015844 monoamine transport
GO:0015850 organic hydroxy compound transport
GO:0015872 dopamine transport
GO:0017038 protein import
GO:0018958 phenol-containing compound metabolic process
GO:0019098 reproductive behavior
GO:0019226 transmission of nerve impulse
GO:0019228 neuronal action potential
GO:0021537 telencephalon development
GO:0021542 dentate gyrus development
GO:0021543 pallium development
GO:0021544 subpallium development
GO:0021756 striatum development
GO:0021761 limbic system development
GO:0021766 hippocampus development
GO:0021782 glial cell development
GO:0021826 substrate-independent telencephalic tangential migration
GO:0021830 interneuron migration from the subpallium to the cortex
GO:0021843 substrate-independent telencephalic tangential interneuron migration
GO:0021853 cerebral cortex GABAergic interneuron migration
GO:0021872 forebrain generation of neurons
GO:0021879 forebrain neuron differentiation
GO:0021884 forebrain neuron development
GO:0021885 forebrain cell migration
GO:0021892 cerebral cortex GABAergic interneuron differentiation
GO:0021894 cerebral cortex GABAergic interneuron development
GO:0021895 cerebral cortex neuron differentiation
GO:0021953 central nervous system neuron differentiation
GO:0021954 central nervous system neuron development
GO:0022029 telencephalon cell migration
GO:0030335 positive regulation of cell migration
GO:0030432 peristalsis
GO:0030534 adult behavior
GO:0030799 regulation of cyclic nucleotide metabolic process
GO:0030801 positive regulation of cyclic nucleotide metabolic process
GO:0030802 regulation of cyclic nucleotide biosynthetic process
GO:0030804 positive regulation of cyclic nucleotide biosynthetic process
GO:0030808 regulation of nucleotide biosynthetic process
GO:0030810 positive regulation of nucleotide biosynthetic process
GO:0030814 regulation of cAMP metabolic process
GO:0030816 positive regulation of cAMP metabolic process
GO:0030817 regulation of cAMP biosynthetic process
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0030900 forebrain development
GO:0031279 regulation of cyclase activity
GO:0031281 positive regulation of cyclase activity
GO:0032102 negative regulation of response to external stimulus
GO:0032225 regulation of synaptic transmission, dopaminergic
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033238 regulation of cellular amine metabolic process
GO:0033555 multicellular organismal response to stress
GO:0034504 protein localization to nucleus
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035106 operant conditioning
GO:0035150 regulation of tube size
GO:0035249 synaptic transmission, glutamatergic
GO:0035637 multicellular organismal signaling
GO:0040017 positive regulation of locomotion
GO:0042053 regulation of dopamine metabolic process
GO:0042063 gliogenesis
GO:0042069 regulation of catecholamine metabolic process
GO:0042220 response to cocaine
GO:0042311 vasodilation
GO:0042391 regulation of membrane potential
GO:0042417 dopamine metabolic process
GO:0042493 response to drug
GO:0042596 fear response
GO:0042711 maternal behavior
GO:0043266 regulation of potassium ion transport
GO:0043268 positive regulation of potassium ion transport
GO:0043270 positive regulation of ion transport
GO:0043279 response to alkaloid
GO:0044106 cellular amine metabolic process
GO:0044708 single-organism behavior
GO:0044744 protein targeting to nucleus
GO:0045761 regulation of adenylate cyclase activity
GO:0045762 positive regulation of adenylate cyclase activity
GO:0045981 positive regulation of nucleotide metabolic process
GO:0046058 cAMP metabolic process
GO:0046323 glucose import
GO:0046390 ribose phosphate biosynthetic process
GO:0046958 nonassociative learning
GO:0046959 habituation
GO:0046960 sensitization
GO:0048148 behavioral response to cocaine
GO:0048167 regulation of synaptic plasticity
GO:0048708 astrocyte differentiation
GO:0048871 multicellular organismal homeostasis
GO:0050804 modulation of synaptic transmission
GO:0050805 negative regulation of synaptic transmission
GO:0050806 positive regulation of synaptic transmission
GO:0050808 synapse organization
GO:0050880 regulation of blood vessel size
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051272 positive regulation of cellular component movement
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051339 regulation of lyase activity
GO:0051349 positive regulation of lyase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0051580 regulation of neurotransmitter uptake
GO:0051583 dopamine uptake involved in synaptic transmission
GO:0051584 regulation of dopamine uptake involved in synaptic transmission
GO:0051588 regulation of neurotransmitter transport
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0051934 catecholamine uptake involved in synaptic transmission
GO:0051937 catecholamine transport
GO:0051940 regulation of catecholamine uptake involved in synaptic transmission
GO:0051952 regulation of amine transport
GO:0051966 regulation of synaptic transmission, glutamatergic
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0052652 cyclic purine nucleotide metabolic process
GO:0055074 calcium ion homeostasis
GO:0060134 prepulse inhibition
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0060291 long-term synaptic potentiation
GO:0060292 long term synaptic depression
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060746 parental behavior
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070838 divalent metal ion transport
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071867 response to monoamine
GO:0071868 cellular response to monoamine stimulus
GO:0071869 response to catecholamine
GO:0071870 cellular response to catecholamine stimulus
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072522 purine-containing compound biosynthetic process
GO:0090066 regulation of anatomical structure size
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0090493 catecholamine uptake
GO:0090494 dopamine uptake
GO:0090659 walking behavior
GO:0097154 GABAergic neuron differentiation
GO:0097553 calcium ion transmembrane import into cytosol
GO:0098657 import into cell
GO:0098810 neurotransmitter reuptake
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:1900371 regulation of purine nucleotide biosynthetic process
GO:1900373 positive regulation of purine nucleotide biosynthetic process
GO:1900542 regulation of purine nucleotide metabolic process
GO:1900544 positive regulation of purine nucleotide metabolic process
GO:1901293 nucleoside phosphate biosynthetic process
GO:1901615 organic hydroxy compound metabolic process
GO:1902593 single-organism nuclear import
GO:1902656 calcium ion import into cytosol
GO:1903169 regulation of calcium ion transmembrane transport
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:1904936 interneuron migration
GO:2000021 regulation of ion homeostasis
GO:2000147 positive regulation of cell motility
Molecular Function GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs
GO:0004952 dopamine neurotransmitter receptor activity
GO:0030594 neurotransmitter receptor activity
GO:0035240 dopamine binding
GO:1901338 catecholamine binding
Cellular Component GO:0005929 cilium
GO:0031253 cell projection membrane
GO:0031513 nonmotile primary cilium
GO:0044441 ciliary part
GO:0060170 ciliary membrane
GO:0072372 primary cilium
> KEGG and Reactome Pathway
 
KEGG hsa04020 Calcium signaling pathway
hsa04024 cAMP signaling pathway
hsa04080 Neuroactive ligand-receptor interaction
hsa04540 Gap junction
hsa04728 Dopaminergic synapse
Reactome R-HSA-375280: Amine ligand-binding receptors
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-390651: Dopamine receptors
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DRD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DRD1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DRD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6040.527
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0820.952
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.4670.35
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.2220.602
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.3110.615
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.8680.00892
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DRD1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131115.4015.40.482
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DRD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DRD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DRD1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DRD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DRD1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DRD1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDRD1
Namedopamine receptor D1
Aliases DADRA; dopamine D1 receptor; D(1A) dopamine receptor
Chromosomal Location5q34-q35
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DRD1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting DRD1.
ID Name Drug Type Targets #Targets
DB00246ZiprasidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB00248CabergolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......22
DB00248CabergolineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1 ......22
DB00268RopiniroleSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......14
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00334OlanzapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1 ......50
DB00353MethylergometrineSmall MoleculeDRD1, HTR2B2
DB00363ClozapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CALY, CHRM1, CHRM2, CHRM3, ......27
DB00370MirtazapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, DRD1 ......23
DB00372ThiethylperazineSmall MoleculeDRD1, DRD2, DRD43
DB00397PhenylpropanolamineSmall MoleculeADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD16
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00408LoxapineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, CHRM1, CHRM2, CHRM3 ......34
DB00413PramipexoleSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......14
DB00420PromazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00458ImipramineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......25
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00477ChlorpromazineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CH ......31
DB00502HaloperidolSmall MoleculeDRD1, DRD2, DRD3, GRIN2B, HTR2A, MCHR1, SLC18A27
DB00508TriflupromazineSmall MoleculeCHRM1, CHRM2, DRD1, DRD2, HTR2B5
DB00543AmoxapineSmall MoleculeADRA1A, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2A, ADRA2B, ADRA2C, CH ......48
DB00555LamotrigineSmall MoleculeADORA1, ADORA2A, ADRA1A, ADRA2A, ADRB1, CACNA1E, CHRM1, CHRM2, CHR ......44
DB00568CinnarizineSmall MoleculeCACNA1C, CACNA1D, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CHR ......16
DB00589LisurideSmall MoleculeADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, HTR1B ......15
DB00623FluphenazineSmall MoleculeAR, DRD1, DRD2, HTR2A, HTR2C5
DB00679ThioridazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR2A, KCNH26
DB00696ErgotamineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, DRD1, DRD2, DRD5, HTR1A, H ......16
DB00714ApomorphineSmall MoleculeADRA2A, ADRA2B, ADRA2C, CALY, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A, ......15
DB00726TrimipramineSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, ......24
DB00734RisperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, DRD4, HR ......15
DB00777PropiomazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, D ......14
DB00800FenoldopamSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD58
DB00805MinaprineSmall MoleculeACHE, CHRM1, DRD1, DRD2, HTR2A, HTR2B, HTR2C, MAOA, SLC6A49
DB00850PerphenazineSmall MoleculeDRD1, DRD22
DB00875FlupentixolSmall MoleculeADRA1A, CHRM1, DRD1, DRD2, HTR2A5
DB00988DopamineSmall MoleculeDBH, DRD1, DRD1, DRD2, DRD3, DRD4, DRD5, DRD5, HTR1A, HTR3A, HTR3B ......17
DB00988DopamineSmall MoleculeDBH, DRD1, DRD1, DRD2, DRD3, DRD4, DRD5, DRD5, HTR1A, HTR3A, HTR3B ......17
DB01038CarphenazineSmall MoleculeDRD1, DRD2, DRD53
DB01049Ergoloid mesylateSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, GABRA1 ......41
DB01063AcetophenazineSmall MoleculeAR, DRD1, DRD23
DB01186PergolideSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......17
DB01200BromocriptineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......18
DB01224QuetiapineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......26
DB01235LevodopaSmall MoleculeDRD1, DRD2, DRD3, DRD4, DRD55
DB01238AripiprazoleSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM3, CHRM4 ......25
DB01239ChlorprothixeneSmall MoleculeCHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, HRH1, HTR2A, ......12
DB01267PaliperidoneSmall MoleculeADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, CYP2D6, CYP3A4, CYP3A5, DR ......18
DB01403MethotrimeprazineSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, CHRM1, CHRM2, CHRM ......19
DB01608PropericiazineSmall MoleculeADRA1B, ADRA2A, AR, DRD14
DB01614AcepromazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A6
DB01621PipotiazineSmall MoleculeDRD1, DRD2, HTR1A, HTR2A4
DB01622ThioproperazineSmall MoleculeADRA1A, ADRA1B, DRD1, DRD2, HTR1A, HTR2A6
DB01623ThiothixeneSmall MoleculeDRD1, DRD2, HTR2A3
DB01624ZuclopenthixolSmall MoleculeADRA1A, ADRA2A, DRD1, DRD2, DRD5, HRH1, HTR2A7
DB04946IloperidoneSmall MoleculeADRA1A, ADRA2C, DRD1, DRD2, DRD3, DRD4, HRH1, HTR1A, HTR2A, HTR6, ......11
DB05271RotigotineSmall MoleculeADRA2B, DRD1, DRD2, DRD3, DRD4, DRD5, HTR1A7
DB06148MianserinSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, DRD1, DRD2, DRD3, ......23
DB06216AsenapineSmall MoleculeADRA1A, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, DRD1, DRD2, DRD3, DR ......20
DB09097QuinagolideSmall MoleculeDRD1, DRD2, DRD53
DB09225ZotepineSmall MoleculeDRD1, DRD2, DRD5, HTR2A, HTR6, HTR7, SLC6A2, SLC6A48
DB09286PipamperoneSmall MoleculeADRA1A, ADRA1B, ADRA1D, ADRA2A, DRD1, DRD2, DRD3, DRD4, HTR2A, HTR ......10
DB12093TetrahydropalmatineSmall MoleculeDRD1, DRD22
DB12890DihydrexidineSmall MoleculeDRD11