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Browse DNLZ

Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion
Domain PF05180 DNL zinc finger
Function

May function as a co-chaperone towards HSPA9/mortalin which, by itself, is prone to self-aggregation.

> Gene Ontology
 
Biological Process GO:0006457 protein folding
GO:0006626 protein targeting to mitochondrion
GO:0006839 mitochondrial transport
GO:0017038 protein import
GO:0030150 protein import into mitochondrial matrix
GO:0031647 regulation of protein stability
GO:0044743 intracellular protein transmembrane import
GO:0050821 protein stabilization
GO:0065002 intracellular protein transmembrane transport
GO:0070585 protein localization to mitochondrion
GO:0071806 protein transmembrane transport
GO:0072655 establishment of protein localization to mitochondrion
GO:1990542 mitochondrial transmembrane transport
Molecular Function GO:0051087 chaperone binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG -
Reactome -
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DNLZ and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DNLZ in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DNLZ in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8770.0387
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-1.3560.464
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.540.73
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2580.621
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0750.951
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6820.62
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4250.199
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0510.925
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.7530.179
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.6890.569
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2270.889
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1140.26
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DNLZ. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DNLZ. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DNLZ.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DNLZ. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DNLZ expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DNLZ and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDNLZ
NameDNL-type zinc finger
Aliases RP11-413M3.2; ZIM17; bA413M3.2; TIMM15; translocase of inner mitochondrial membrane 15 homolog (yeast); HSP7 ......
Chromosomal Location9q34.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DNLZ collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.