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Browse DHH

Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Desert hedgehog protein N-product: Cell membrane Lipid-anchor Extracellular side Note=The N-terminal peptide remains associated with the cell surface. ; SUBCELLULAR LOCATION: Desert hedgehog protein C-product: Secreted, extracellular space Note=The C-terminal peptide diffuses from the cell.
Domain PF01085 Hedgehog amino-terminal signalling domain
PF01079 Hint module
Function

Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.

> Gene Ontology
 
Biological Process GO:0006694 steroid biosynthetic process
GO:0007272 ensheathment of neurons
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007530 sex determination
GO:0007548 sex differentiation
GO:0008202 steroid metabolic process
GO:0008366 axon ensheathment
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030238 male sex determination
GO:0032355 response to estradiol
GO:0033327 Leydig cell differentiation
GO:0042552 myelination
GO:0043627 response to estrogen
GO:0045137 development of primary sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046661 male sex differentiation
GO:0046890 regulation of lipid biosynthetic process
GO:0048232 male gamete generation
GO:0048515 spermatid differentiation
GO:0048608 reproductive structure development
GO:0050810 regulation of steroid biosynthetic process
GO:0061458 reproductive system development
Molecular Function GO:0005113 patched binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04340 Hedgehog signaling pathway
Reactome R-HSA-5635838: Activation of SMO
R-HSA-373080: Class B/2 (Secretin family receptors)
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-500792: GPCR ligand binding
R-HSA-5658034: HHAT G278V abrogates palmitoylation of Hh-Np
R-HSA-5632684: Hedgehog 'on' state
R-HSA-5358346: Hedgehog ligand biogenesis
R-HSA-5387390: Hh mutants abrogate ligand secretion
R-HSA-5632681: Ligand-receptor interactions
R-HSA-5362798: Release of Hh-Np from the secreting cell
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-5358351: Signaling by Hedgehog
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DHH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DHH in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.53 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DHH in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.5080.333
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.3490.687
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.620.393
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4250.539
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1570.884
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.7670.529
729033130MelanomaallAnti-PD-1 (nivolumab) 262300.999
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4460.661
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.5620.62
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.080.84
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.1250.825
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1780.328
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DHH in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414250250.222
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277302.7-2.71
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275903.4-3.41
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86016.7-16.70.429
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DHH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DHH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DHH.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DHH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DHH expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DHH and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDHH
Namedesert hedgehog
Aliases HHG-3; MGC35145; desert hedgehog (Drosophila) homolog; GDXYM; SRXY7; desert hedgehog homolog; mutant desert ......
Chromosomal Location12q13.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DHH collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.