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Browse DDX20

Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems).
Domain PF00270 DEAD/DEAH box helicase
PF00271 Helicase conserved C-terminal domain
Function

The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).

> Gene Ontology
 
Biological Process GO:0000244 spliceosomal tri-snRNP complex assembly
GO:0000375 RNA splicing, via transesterification reactions
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
GO:0000387 spliceosomal snRNP assembly
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0006694 steroid biosynthetic process
GO:0006913 nucleocytoplasmic transport
GO:0007281 germ cell development
GO:0007292 female gamete generation
GO:0008202 steroid metabolic process
GO:0008380 RNA splicing
GO:0010501 RNA secondary structure unwinding
GO:0019216 regulation of lipid metabolic process
GO:0019218 regulation of steroid metabolic process
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022613 ribonucleoprotein complex biogenesis
GO:0022618 ribonucleoprotein complex assembly
GO:0046890 regulation of lipid biosynthetic process
GO:0048477 oogenesis
GO:0050810 regulation of steroid biosynthetic process
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0071826 ribonucleoprotein complex subunit organization
Molecular Function GO:0003724 RNA helicase activity
GO:0004004 ATP-dependent RNA helicase activity
GO:0004386 helicase activity
GO:0008026 ATP-dependent helicase activity
GO:0008134 transcription factor binding
GO:0008186 RNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0030674 protein binding, bridging
GO:0042623 ATPase activity, coupled
GO:0042826 histone deacetylase binding
GO:0060090 binding, bridging
GO:0070035 purine NTP-dependent helicase activity
GO:0070491 repressing transcription factor binding
Cellular Component GO:0016604 nuclear body
GO:0017053 transcriptional repressor complex
GO:0032797 SMN complex
GO:0034719 SMN-Sm protein complex
GO:0090568 nuclear transcriptional repressor complex
GO:0090571 RNA polymerase II transcription repressor complex
GO:0097504 Gemini of coiled bodies
> KEGG and Reactome Pathway
 
KEGG hsa03013 RNA transport
Reactome R-HSA-74160: Gene Expression
R-HSA-194441: Metabolism of non-coding RNA
R-HSA-191859: snRNP Assembly
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DDX20 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DDX20 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.03; FDR: 0.04220 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DDX20 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0050.978
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2420.857
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1870.853
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1230.568
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1130.945
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.1350.949
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.060.847
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1280.926
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0140.993
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1010.905
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5370.638
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0890.169
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DDX20 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 592011.18.91
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DDX20. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DDX20. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DDX20.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DDX20. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DDX20 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DDX20 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDDX20
NameDEAD (Asp-Glu-Ala-Asp) box polypeptide 20
Aliases DP103; GEMIN3; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD box protein 20; DEAD box protein ......
Chromosomal Location1p21.1-p13.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DDX20 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.