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Browse DDC

Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location -
Domain PF00282 Pyridoxal-dependent decarboxylase conserved domain
Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

> Gene Ontology
 
Biological Process GO:0006520 cellular amino acid metabolic process
GO:0006576 cellular biogenic amine metabolic process
GO:0006584 catecholamine metabolic process
GO:0006586 indolalkylamine metabolic process
GO:0006836 neurotransmitter transport
GO:0007568 aging
GO:0007623 circadian rhythm
GO:0009308 amine metabolic process
GO:0009309 amine biosynthetic process
GO:0009404 toxin metabolic process
GO:0009636 response to toxic substance
GO:0009712 catechol-containing compound metabolic process
GO:0009713 catechol-containing compound biosynthetic process
GO:0009820 alkaloid metabolic process
GO:0010259 multicellular organism aging
GO:0015837 amine transport
GO:0015842 aminergic neurotransmitter loading into synaptic vesicle
GO:0017085 response to insecticide
GO:0018958 phenol-containing compound metabolic process
GO:0019748 secondary metabolic process
GO:0033076 isoquinoline alkaloid metabolic process
GO:0035690 cellular response to drug
GO:0042401 cellular biogenic amine biosynthetic process
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042423 catecholamine biosynthetic process
GO:0042427 serotonin biosynthetic process
GO:0042428 serotonin metabolic process
GO:0042430 indole-containing compound metabolic process
GO:0042435 indole-containing compound biosynthetic process
GO:0042493 response to drug
GO:0043279 response to alkaloid
GO:0044106 cellular amine metabolic process
GO:0046189 phenol-containing compound biosynthetic process
GO:0046219 indolalkylamine biosynthetic process
GO:0046684 response to pyrethroid
GO:0048511 rhythmic process
GO:0052314 phytoalexin metabolic process
GO:0071312 cellular response to alkaloid
GO:0071417 cellular response to organonitrogen compound
GO:0098700 neurotransmitter loading into synaptic vesicle
GO:0099504 synaptic vesicle cycle
GO:1901160 primary amino compound metabolic process
GO:1901162 primary amino compound biosynthetic process
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
Molecular Function GO:0004058 aromatic-L-amino-acid decarboxylase activity
GO:0016597 amino acid binding
GO:0016829 lyase activity
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0031406 carboxylic acid binding
GO:0036468 L-dopa decarboxylase activity
GO:0043168 anion binding
GO:0048037 cofactor binding
Cellular Component GO:0008021 synaptic vesicle
GO:0030133 transport vesicle
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0070382 exocytic vesicle
GO:0098793 presynapse
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04726 Serotonergic synapse
hsa04728 Dopaminergic synapse
hsa00340 Histidine metabolism
hsa00350 Tyrosine metabolism
hsa00360 Phenylalanine metabolism
hsa00380 Tryptophan metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-209776: Amine-derived hormones
R-HSA-209905: Catecholamine biosynthesis
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-209931: Serotonin and melatonin biosynthesis
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between DDC and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of DDC in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of DDC in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.2050.415
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0570.919
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.40.403
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.4390.606
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4030.753
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.4890.282
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.610.493
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.1950.905
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.5770.354
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.9720.665
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.8960.766
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.920.0148
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of DDC in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47500500.109
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of DDC. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of DDC. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by DDC.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of DDC. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of DDC expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between DDC and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolDDC
Namedopa decarboxylase (aromatic L-amino acid decarboxylase)
Aliases AADC; DOPA decarboxylase; Aromatic-L-amino-acid decarboxylase
Chromosomal Location7p12.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting DDC collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting DDC.
ID Name Drug Type Targets #Targets
DB00114Pyridoxal PhosphateSmall MoleculeAADAT, ABAT, AGXT, AGXT2, ALAS1, ALAS2, AZIN2, BCAT1, BCAT2, CBS, ......54
DB00190CarbidopaSmall MoleculeDDC1
DB00968MethyldopaSmall MoleculeADRA2A, DDC2
DB05307CHF-1512Small MoleculeDDC1