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Browse CTNNA1

Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Isoform 1: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries.; SUBCELLULAR LOCATION: Isoform 3: Cell membrane Peripheral membrane protein Cytoplasmic side
Domain PF01044 Vinculin family
Function

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

> Gene Ontology
 
Biological Process GO:0001541 ovarian follicle development
GO:0007015 actin filament organization
GO:0007043 cell-cell junction assembly
GO:0007163 establishment or maintenance of cell polarity
GO:0007224 smoothened signaling pathway
GO:0007229 integrin-mediated signaling pathway
GO:0007405 neuroblast proliferation
GO:0007406 negative regulation of neuroblast proliferation
GO:0007548 sex differentiation
GO:0007568 aging
GO:0008406 gonad development
GO:0008584 male gonad development
GO:0008585 female gonad development
GO:0008589 regulation of smoothened signaling pathway
GO:0010721 negative regulation of cell development
GO:0016264 gap junction assembly
GO:0022602 ovulation cycle process
GO:0031099 regeneration
GO:0031102 neuron projection regeneration
GO:0031103 axon regeneration
GO:0034329 cell junction assembly
GO:0034330 cell junction organization
GO:0034332 adherens junction organization
GO:0038034 signal transduction in absence of ligand
GO:0040013 negative regulation of locomotion
GO:0042475 odontogenesis of dentin-containing tooth
GO:0042476 odontogenesis
GO:0042692 muscle cell differentiation
GO:0042698 ovulation cycle
GO:0043297 apical junction assembly
GO:0043627 response to estrogen
GO:0045137 development of primary sexual characteristics
GO:0045216 cell-cell junction organization
GO:0045880 positive regulation of smoothened signaling pathway
GO:0046545 development of primary female sexual characteristics
GO:0046546 development of primary male sexual characteristics
GO:0046660 female sex differentiation
GO:0046661 male sex differentiation
GO:0048511 rhythmic process
GO:0048608 reproductive structure development
GO:0048678 response to axon injury
GO:0050768 negative regulation of neurogenesis
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051259 protein oligomerization
GO:0051271 negative regulation of cellular component movement
GO:0051291 protein heterooligomerization
GO:0051961 negative regulation of nervous system development
GO:0061351 neural precursor cell proliferation
GO:0061458 reproductive system development
GO:0061564 axon development
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071680 response to indole-3-methanol
GO:0071681 cellular response to indole-3-methanol
GO:0072089 stem cell proliferation
GO:0072091 regulation of stem cell proliferation
GO:0090136 epithelial cell-cell adhesion
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097305 response to alcohol
GO:0097306 cellular response to alcohol
GO:1901099 negative regulation of signal transduction in absence of ligand
GO:1902692 regulation of neuroblast proliferation
GO:2000146 negative regulation of cell motility
GO:2000177 regulation of neural precursor cell proliferation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000647 negative regulation of stem cell proliferation
GO:2001044 regulation of integrin-mediated signaling pathway
GO:2001045 negative regulation of integrin-mediated signaling pathway
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Molecular Function GO:0003779 actin binding
GO:0008013 beta-catenin binding
GO:0017166 vinculin binding
GO:0045295 gamma-catenin binding
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
GO:0098631 protein binding involved in cell adhesion
GO:0098632 protein binding involved in cell-cell adhesion
GO:0098641 cadherin binding involved in cell-cell adhesion
Cellular Component GO:0001669 acrosomal vesicle
GO:0005901 caveola
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0014704 intercalated disc
GO:0015629 actin cytoskeleton
GO:0016342 catenin complex
GO:0016600 flotillin complex
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030027 lamellipodium
GO:0030055 cell-substrate junction
GO:0030141 secretory granule
GO:0031252 cell leading edge
GO:0043296 apical junction complex
GO:0044291 cell-cell contact zone
GO:0044853 plasma membrane raft
GO:0045121 membrane raft
GO:0097223 sperm part
GO:0098589 membrane region
GO:0098857 membrane microdomain
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG hsa04390 Hippo signaling pathway
hsa04520 Adherens junction
hsa04670 Leukocyte transendothelial migration
Reactome R-HSA-418990: Adherens junctions interactions
R-HSA-375170: CDO in myogenesis
R-HSA-446728: Cell junction organization
R-HSA-1500931: Cell-Cell communication
R-HSA-421270: Cell-cell junction organization
R-HSA-1266738: Developmental Biology
R-HSA-525793: Myogenesis
R-HSA-195258: RHO GTPase Effectors
R-HSA-5626467: RHO GTPases activate IQGAPs
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-194138: Signaling by VEGF
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218920: VEGFR2 mediated vascular permeability
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CTNNA1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CTNNA1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.53 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CTNNA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.2190.419
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4180.888
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0680.974
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2570.45
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0970.972
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7070.844
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0740.886
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0620.978
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0840.974
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.1040.963
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.5610.868
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0530.402
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CTNNA1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277301.4-1.41
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275901.7-1.71
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610100-1000.143
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CTNNA1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CTNNA1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CTNNA1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CTNNA1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CTNNA1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CTNNA1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCTNNA1
Namecatenin (cadherin-associated protein), alpha 1, 102kDa
Aliases CAP102; catenin (cadherin-associated protein), alpha 1 (102kD); alpha E-catenin; alpha-E-catenin; alpha-cate ......
Chromosomal Location5q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CTNNA1 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.