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Browse CRCP

Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cell membrane Peripheral membrane protein Cytoplasmic side
Domain PF03874 RNA polymerase Rpb4
Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity). ; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues.

> Gene Ontology
 
Biological Process GO:0001819 positive regulation of cytokine production
GO:0006352 DNA-templated transcription, initiation
GO:0006383 transcription from RNA polymerase III promoter
GO:0006384 transcription initiation from RNA polymerase III promoter
GO:0007218 neuropeptide signaling pathway
GO:0009615 response to virus
GO:0032479 regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0032606 type I interferon production
GO:0051607 defense response to virus
GO:0098542 defense response to other organism
Molecular Function GO:0001056 RNA polymerase III activity
GO:0001635 calcitonin gene-related peptide receptor activity
GO:0001653 peptide receptor activity
GO:0003899 DNA-directed RNA polymerase activity
GO:0008528 G-protein coupled peptide receptor activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 RNA polymerase activity
GO:0097642 calcitonin family receptor activity
Cellular Component GO:0000428 DNA-directed RNA polymerase complex
GO:0001669 acrosomal vesicle
GO:0005666 DNA-directed RNA polymerase III complex
GO:0009360 DNA polymerase III complex
GO:0030141 secretory granule
GO:0030880 RNA polymerase complex
GO:0042575 DNA polymerase complex
GO:0055029 nuclear DNA-directed RNA polymerase complex
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0097223 sperm part
GO:0099503 secretory vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1834949: Cytosolic sensors of pathogen-associated DNA
R-HSA-74160: Gene Expression
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-504046: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
R-HSA-749476: RNA Polymerase III Abortive And Retractive Initiation
R-HSA-73780: RNA Polymerase III Chain Elongation
R-HSA-74158: RNA Polymerase III Transcription
R-HSA-76046: RNA Polymerase III Transcription Initiation
R-HSA-76061: RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066: RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071: RNA Polymerase III Transcription Initiation From Type 3 Promoter
R-HSA-73980: RNA Polymerase III Transcription Termination
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CRCP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CRCP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.54 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CRCP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0590.769
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.060.974
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1460.915
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1080.716
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.20.886
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0130.993
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1050.752
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0290.985
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.270.87
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0930.948
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.6990.734
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.010.867
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CRCP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CRCP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CRCP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CRCP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CRCP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CRCP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCRCP
NameCGRP receptor component
Aliases CGRP-RCP; RCP9; calcitonin gene-related peptide-receptor component protein; CGRPRCP; CGRP-receptor component ......
Chromosomal Location7q11.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CRCP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.