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Browse CPS1

Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Mitochondrion Nucleus, nucleolus
Domain PF02786 Carbamoyl-phosphate synthase L chain
PF02787 Carbamoyl-phosphate synthetase large chain
PF00988 Carbamoyl-phosphate synthase small chain
PF00117 Glutamine amidotransferase class-I
PF02142 MGS-like domain
Function

Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.

> Gene Ontology
 
Biological Process GO:0000050 urea cycle
GO:0000052 citrulline metabolic process
GO:0000096 sulfur amino acid metabolic process
GO:0000272 polysaccharide catabolic process
GO:0001101 response to acid chemical
GO:0001889 liver development
GO:0002237 response to molecule of bacterial origin
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005980 glycogen catabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006112 energy reserve metabolic process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006520 cellular amino acid metabolic process
GO:0006525 arginine metabolic process
GO:0006526 arginine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0006638 neutral lipid metabolic process
GO:0006639 acylglycerol metabolic process
GO:0006641 triglyceride metabolic process
GO:0006790 sulfur compound metabolic process
GO:0007494 midgut development
GO:0008015 blood circulation
GO:0008652 cellular amino acid biosynthetic process
GO:0009064 glutamine family amino acid metabolic process
GO:0009084 glutamine family amino acid biosynthetic process
GO:0009112 nucleobase metabolic process
GO:0009251 glucan catabolic process
GO:0009636 response to toxic substance
GO:0009991 response to extracellular stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0014074 response to purine-containing compound
GO:0014075 response to amine
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016042 lipid catabolic process
GO:0016052 carbohydrate catabolic process
GO:0016053 organic acid biosynthetic process
GO:0019240 citrulline biosynthetic process
GO:0019433 triglyceride catabolic process
GO:0019627 urea metabolic process
GO:0019856 pyrimidine nucleobase biosynthetic process
GO:0031667 response to nutrient levels
GO:0031960 response to corticosteroid
GO:0032094 response to food
GO:0032496 response to lipopolysaccharide
GO:0033762 response to glucagon
GO:0034201 response to oleic acid
GO:0035150 regulation of tube size
GO:0042311 vasodilation
GO:0042312 regulation of vasodilation
GO:0042493 response to drug
GO:0042594 response to starvation
GO:0043200 response to amino acid
GO:0043434 response to peptide hormone
GO:0044042 glucan metabolic process
GO:0044057 regulation of system process
GO:0044242 cellular lipid catabolic process
GO:0044247 cellular polysaccharide catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044275 cellular carbohydrate catabolic process
GO:0044283 small molecule biosynthetic process
GO:0044344 cellular response to fibroblast growth factor stimulus
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0045909 positive regulation of vasodilation
GO:0046112 nucleobase biosynthetic process
GO:0046209 nitric oxide metabolic process
GO:0046394 carboxylic acid biosynthetic process
GO:0046461 neutral lipid catabolic process
GO:0046464 acylglycerol catabolic process
GO:0046486 glycerolipid metabolic process
GO:0046503 glycerolipid catabolic process
GO:0046683 response to organophosphorus
GO:0048545 response to steroid hormone
GO:0048565 digestive tract development
GO:0048732 gland development
GO:0050667 homocysteine metabolic process
GO:0050880 regulation of blood vessel size
GO:0051384 response to glucocorticoid
GO:0051591 response to cAMP
GO:0055081 anion homeostasis
GO:0055123 digestive system development
GO:0060416 response to growth hormone
GO:0061008 hepaticobiliary system development
GO:0070365 hepatocyte differentiation
GO:0070408 carbamoyl phosphate metabolic process
GO:0070409 carbamoyl phosphate biosynthetic process
GO:0071320 cellular response to cAMP
GO:0071375 cellular response to peptide hormone stimulus
GO:0071377 cellular response to glucagon stimulus
GO:0071396 cellular response to lipid
GO:0071400 cellular response to oleic acid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071548 response to dexamethasone
GO:0071774 response to fibroblast growth factor
GO:0071941 nitrogen cycle metabolic process
GO:0072527 pyrimidine-containing compound metabolic process
GO:0072528 pyrimidine-containing compound biosynthetic process
GO:0072593 reactive oxygen species metabolic process
GO:0090066 regulation of anatomical structure size
GO:1901605 alpha-amino acid metabolic process
GO:1901607 alpha-amino acid biosynthetic process
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1990267 response to transition metal nanoparticle
GO:2001057 reactive nitrogen species metabolic process
Molecular Function GO:0004070 aspartate carbamoyltransferase activity
GO:0004087 carbamoyl-phosphate synthase (ammonia) activity
GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO:0004151 dihydroorotase activity
GO:0004175 endopeptidase activity
GO:0005543 phospholipid binding
GO:0016595 glutamate binding
GO:0016741 transferase activity, transferring one-carbon groups
GO:0016743 carboxyl- or carbamoyltransferase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0031406 carboxylic acid binding
GO:0043168 anion binding
GO:0072341 modified amino acid binding
Cellular Component GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0009295 nucleoid
GO:0042645 mitochondrial nucleoid
> KEGG and Reactome Pathway
 
KEGG hsa00250 Alanine, aspartate and glutamate metabolism
hsa00910 Nitrogen metabolism
hsa01100 Metabolic pathways
hsa01200 Carbon metabolism
hsa01230 Biosynthesis of amino acids
Reactome R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-351202: Metabolism of polyamines
R-HSA-70635: Urea cycle
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CPS1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CPS1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.5630.016
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.7940.534
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)872.1390.0185
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4640.331
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.7620.618
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.10.95
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2840.71
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5840.657
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2250.887
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-1.1420.398
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.2510.879
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0580.824
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CPS1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.46.80.61
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21179.509.50.492
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91622.2022.20.12
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59400400.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161407.1-7.10.467
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CPS1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CPS1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CPS1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CPS1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CPS1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CPS1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCPS1
Namecarbamoyl-phosphate synthase 1, mitochondrial
Aliases carbamoyl-phosphate synthetase 1, mitochondrial; CPSASE1; PHN; carbamoylphosphate synthetase I; CPSase I; Ca ......
Chromosomal Location2p
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CPS1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CPS1.
ID Name Drug Type Targets #Targets
DB06775Carglumic AcidSmall MoleculeCPS11