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Browse CHP1

Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Cytoplasm, cytoskeleton Endomembrane system Endoplasmic reticulum-Golgi intermediate compartment Endoplasmic reticulum Cell membrane Membrane Lipid-anchor Note=Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1 at the reticulum endoplasmic and plasma membrane. Colocalizes with STK17B at the plasma membrane.
Domain PF13499 EF-hand domain pair
Function

Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Affects the pH sensitivity of SLC9A1/NHE1 by increasing its sensitivity at acidic pH. Required for the stabilization and localization of SLC9A1/NHE1 at the plasma membrane. Inhibits serum- and GTPase-stimulated Na(+)/H(+) exchange. Plays a role as an inhibitor of ribosomal RNA transcription by repressing the nucleolar UBF1 transcriptional activity. May sequester UBF1 in the nucleoplasm and limit its translocation to the nucleolus. Associates to the ribosomal gene promoter. Acts as a negative regulator of the calcineurin/NFAT signaling pathway. Inhibits NFAT nuclear translocation and transcriptional activity by suppressing the calcium-dependent calcineurin phosphatase activity. Also negatively regulates the kinase activity of the apoptosis-induced kinase STK17B. Inhibits both STK17B auto- and substrate-phosphorylations in a calcium-dependent manner.

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0001578 microtubule bundle formation
GO:0001933 negative regulation of protein phosphorylation
GO:0002028 regulation of sodium ion transport
GO:0006022 aminoglycan metabolic process
GO:0006026 aminoglycan catabolic process
GO:0006027 glycosaminoglycan catabolic process
GO:0006469 negative regulation of protein kinase activity
GO:0006486 protein glycosylation
GO:0006606 protein import into nucleus
GO:0006611 protein export from nucleus
GO:0006612 protein targeting to membrane
GO:0006813 potassium ion transport
GO:0006814 sodium ion transport
GO:0006818 hydrogen transport
GO:0006885 regulation of pH
GO:0006887 exocytosis
GO:0006913 nucleocytoplasmic transport
GO:0009100 glycoprotein metabolic process
GO:0009101 glycoprotein biosynthetic process
GO:0009268 response to pH
GO:0010155 regulation of proton transport
GO:0010447 response to acidic pH
GO:0010559 regulation of glycoprotein biosynthetic process
GO:0010560 positive regulation of glycoprotein biosynthetic process
GO:0010765 positive regulation of sodium ion transport
GO:0010921 regulation of phosphatase activity
GO:0010923 negative regulation of phosphatase activity
GO:0010959 regulation of metal ion transport
GO:0015672 monovalent inorganic cation transport
GO:0015992 proton transport
GO:0016311 dephosphorylation
GO:0017038 protein import
GO:0017156 calcium ion regulated exocytosis
GO:0019722 calcium-mediated signaling
GO:0019932 second-messenger-mediated signaling
GO:0022406 membrane docking
GO:0022898 regulation of transmembrane transporter activity
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030214 hyaluronan catabolic process
GO:0030641 regulation of cellular pH
GO:0031122 cytoplasmic microtubule organization
GO:0031396 regulation of protein ubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0031952 regulation of protein autophosphorylation
GO:0031953 negative regulation of protein autophosphorylation
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032386 regulation of intracellular transport
GO:0032387 negative regulation of intracellular transport
GO:0032388 positive regulation of intracellular transport
GO:0032409 regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0032415 regulation of sodium:proton antiporter activity
GO:0032417 positive regulation of sodium:proton antiporter activity
GO:0033157 regulation of intracellular protein transport
GO:0033173 calcineurin-NFAT signaling cascade
GO:0033673 negative regulation of kinase activity
GO:0034504 protein localization to nucleus
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035303 regulation of dephosphorylation
GO:0035305 negative regulation of dephosphorylation
GO:0035725 sodium ion transmembrane transport
GO:0042306 regulation of protein import into nucleus
GO:0042308 negative regulation of protein import into nucleus
GO:0042326 negative regulation of phosphorylation
GO:0043270 positive regulation of ion transport
GO:0043413 macromolecule glycosylation
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0044744 protein targeting to nucleus
GO:0045055 regulated exocytosis
GO:0046777 protein autophosphorylation
GO:0046822 regulation of nucleocytoplasmic transport
GO:0046823 negative regulation of nucleocytoplasmic transport
GO:0048016 inositol phosphate-mediated signaling
GO:0050821 protein stabilization
GO:0050848 regulation of calcium-mediated signaling
GO:0050849 negative regulation of calcium-mediated signaling
GO:0051051 negative regulation of transport
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051168 nuclear export
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051222 positive regulation of protein transport
GO:0051224 negative regulation of protein transport
GO:0051259 protein oligomerization
GO:0051346 negative regulation of hydrolase activity
GO:0051348 negative regulation of transferase activity
GO:0051453 regulation of intracellular pH
GO:0055067 monovalent inorganic cation homeostasis
GO:0060049 regulation of protein glycosylation
GO:0060050 positive regulation of protein glycosylation
GO:0061025 membrane fusion
GO:0070085 glycosylation
GO:0070884 regulation of calcineurin-NFAT signaling cascade
GO:0070885 negative regulation of calcineurin-NFAT signaling cascade
GO:0070997 neuron death
GO:0071214 cellular response to abiotic stimulus
GO:0071467 cellular response to pH
GO:0071468 cellular response to acidic pH
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090313 regulation of protein targeting to membrane
GO:0090314 positive regulation of protein targeting to membrane
GO:0090316 positive regulation of intracellular protein transport
GO:0090317 negative regulation of intracellular protein transport
GO:0097720 calcineurin-mediated signaling
GO:1900180 regulation of protein localization to nucleus
GO:1900181 negative regulation of protein localization to nucleus
GO:1901136 carbohydrate derivative catabolic process
GO:1901214 regulation of neuron death
GO:1901565 organonitrogen compound catabolic process
GO:1902305 regulation of sodium ion transmembrane transport
GO:1902307 positive regulation of sodium ion transmembrane transport
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1903018 regulation of glycoprotein metabolic process
GO:1903020 positive regulation of glycoprotein metabolic process
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903321 negative regulation of protein modification by small protein conjugation or removal
GO:1903510 mucopolysaccharide metabolic process
GO:1903533 regulation of protein targeting
GO:1903828 negative regulation of cellular protein localization
GO:1903829 positive regulation of cellular protein localization
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904589 regulation of protein import
GO:1904590 negative regulation of protein import
GO:1904950 negative regulation of establishment of protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000649 regulation of sodium ion transmembrane transporter activity
GO:2000651 positive regulation of sodium ion transmembrane transporter activity
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004860 protein kinase inhibitor activity
GO:0008017 microtubule binding
GO:0015459 potassium channel regulator activity
GO:0015631 tubulin binding
GO:0016247 channel regulator activity
GO:0019207 kinase regulator activity
GO:0019210 kinase inhibitor activity
GO:0019887 protein kinase regulator activity
GO:0048306 calcium-dependent protein binding
Cellular Component GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
GO:0030133 transport vesicle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1630316: Glycosaminoglycan metabolism
R-HSA-2142845: Hyaluronan metabolism
R-HSA-2160916: Hyaluronan uptake and degradation
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CHP1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CHP1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CHP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.8720.00296
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)651.1540.65
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.6660.722
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.140.603
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.1160.946
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1720.938
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0850.834
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.3480.858
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.2550.909
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0550.973
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0170.994
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0040.954
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CHP1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHP1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHP1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHP1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHP1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CHP1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CHP1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCHP1
Namecalcineurin-like EF-hand protein 1
Aliases Sid470p; SLC9A1BP; calcineurin homologous protein; EF-hand calcium-binding domain-containing protein p22; SL ......
Chromosomal Location15q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CHP1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CHP1.
ID Name Drug Type Targets #Targets
DB11093Calcium CitrateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29
DB11348Calcium PhosphateSmall MoleculeCADPS, CADPS2, CALB2, CALR, CALR3, CANX, CAPS, CASQ1, CASQ2, CASR, ......29