[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse CHD8

Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Note=Localizes to the promoter regions of several CTNNB1-responsive genes. Also present at known CTCF target sites.
Domain PF07533 BRK domain
PF00385 Chromo (CHRromatin Organisation MOdifier) domain
PF00271 Helicase conserved C-terminal domain
PF00176 SNF2 family N-terminal domain
Function

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

> Gene Ontology
 
Biological Process GO:0001701 in utero embryonic development
GO:0006338 chromatin remodeling
GO:0006359 regulation of transcription from RNA polymerase III promoter
GO:0006383 transcription from RNA polymerase III promoter
GO:0016055 Wnt signaling pathway
GO:0030111 regulation of Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0032392 DNA geometric change
GO:0032508 DNA duplex unwinding
GO:0043044 ATP-dependent chromatin remodeling
GO:0044346 fibroblast apoptotic process
GO:0045945 positive regulation of transcription from RNA polymerase III promoter
GO:0048565 digestive tract development
GO:0055123 digestive system development
GO:0060070 canonical Wnt signaling pathway
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0071103 DNA conformation change
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0198738 cell-cell signaling by wnt
GO:2000269 regulation of fibroblast apoptotic process
GO:2000270 negative regulation of fibroblast apoptotic process
Molecular Function GO:0002039 p53 binding
GO:0003678 DNA helicase activity
GO:0003682 chromatin binding
GO:0004386 helicase activity
GO:0008013 beta-catenin binding
GO:0008094 DNA-dependent ATPase activity
GO:0016887 ATPase activity
GO:0035064 methylated histone binding
GO:0042393 histone binding
GO:0042623 ATPase activity, coupled
GO:0070016 armadillo repeat domain binding
Cellular Component GO:0034708 methyltransferase complex
GO:0035097 histone methyltransferase complex
GO:0044665 MLL1/2 complex
GO:0071339 MLL1 complex
> KEGG and Reactome Pathway
 
KEGG hsa04310 Wnt signaling pathway
Reactome R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-162582: Signal Transduction
R-HSA-195721: Signaling by Wnt
R-HSA-201681: TCF dependent signaling in response to WNT
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CHD8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CHD8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 STARS Score: 3.71; FDR: 0.047 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CHD8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1380.542
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.4770.746
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.1130.922
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.1470.553
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0350.989
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.380.908
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.2550.511
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.270.876
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.2290.906
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8180.569
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8270.709
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0160.715
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CHD8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.15.91.21
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 414257.117.90.405
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.14.170.339
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.15.160.373
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.311.82.51
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.118.24.91
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.63.7-1.11
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.27.1-0.91
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CHD8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CHD8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CHD8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CHD8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CHD8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CHD8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCHD8
Namechromodomain helicase DNA binding protein 8
Aliases KIAA1564; DUPLIN; HELSNF1; helicase with SNF2 domain 1; AUTS18; ATP-dependent helicase CHD8; axis duplicatio ......
Chromosomal Location14q11.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CHD8 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.