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Browse CFTR

Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Multi-pass membrane protein Early endosome membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Recycling endosome membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Nucleus Note=The channel is internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:17462998, PubMed:19398555, PubMed:20008117). In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia (PubMed:22207244). In Sertoli cells, a processed product is detected in the nucleus (By similarity).
Domain PF00664 ABC transporter transmembrane region
PF00005 ABC transporter
PF14396 Cystic fibrosis TM conductance regulator (CFTR)
Function

Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis (PubMed:26823428). Mediates the transport of chloride ions across the cell membrane (PubMed:10792060, PubMed:11524016, PubMed:11707463, PubMed:12519745, PubMed:15010471, PubMed:12588899, PubMed:17036051, PubMed:19398555, PubMed:19621064, PubMed:22178883, PubMed:25330774, PubMed:1712898, PubMed:8910473, PubMed:9804160, PubMed:12529365, PubMed:17182731, PubMed:26846474, PubMed:28087700). Channel activity is coupled to ATP hydrolysis (PubMed:8910473). The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration (PubMed:15010471, PubMed:19019741). Exerts its function also by modulating the activity of other ion channels and transporters (PubMed:12403779, PubMed:22178883, PubMed:22121115, PubMed:27941075). Plays an important role in airway fluid homeostasis (PubMed:16645176, PubMed:19621064, PubMed:26823428). Contributes to the regulation of the pH and the ion content of the airway surface fluid layer and thereby plays an important role in defense against pathogens (PubMed:14668433, PubMed:16645176, PubMed:26823428). Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex (PubMed:17434346, PubMed:27941075, PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:17182731). Inhibits the activity of the ENaC channel containing subunits SCNN1D, SCNN1B and SCNN1G, but not of the ENaC channel containing subunits SCNN1A, SCNN1B and SCNN1G (PubMed:27941075). May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7 (PubMed:12403779). Can inhibit the chloride channel activity of ANO1 (PubMed:22178883). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (PubMed:19923167, PubMed:27714810).

> Gene Ontology
 
Biological Process GO:0001678 cellular glucose homeostasis
GO:0002790 peptide secretion
GO:0002791 regulation of peptide secretion
GO:0002793 positive regulation of peptide secretion
GO:0006066 alcohol metabolic process
GO:0006694 steroid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006869 lipid transport
GO:0006885 regulation of pH
GO:0006887 exocytosis
GO:0006904 vesicle docking involved in exocytosis
GO:0007281 germ cell development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007585 respiratory gaseous exchange
GO:0008202 steroid metabolic process
GO:0008203 cholesterol metabolic process
GO:0009306 protein secretion
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0009914 hormone transport
GO:0010359 regulation of anion channel activity
GO:0010469 regulation of receptor activity
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0014074 response to purine-containing compound
GO:0015698 inorganic anion transport
GO:0015701 bicarbonate transport
GO:0015711 organic anion transport
GO:0015833 peptide transport
GO:0015850 organic hydroxy compound transport
GO:0015918 sterol transport
GO:0016125 sterol metabolic process
GO:0016126 sterol biosynthetic process
GO:0017157 regulation of exocytosis
GO:0021700 developmental maturation
GO:0022406 membrane docking
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0022898 regulation of transmembrane transporter activity
GO:0023061 signal release
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0030072 peptide hormone secretion
GO:0030073 insulin secretion
GO:0030301 cholesterol transport
GO:0030641 regulation of cellular pH
GO:0032024 positive regulation of insulin secretion
GO:0032409 regulation of transporter activity
GO:0032411 positive regulation of transporter activity
GO:0032412 regulation of ion transmembrane transporter activity
GO:0032414 positive regulation of ion transmembrane transporter activity
GO:0032844 regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0033500 carbohydrate homeostasis
GO:0034284 response to monosaccharide
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0035773 insulin secretion involved in cellular response to glucose stimulus
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042391 regulation of membrane potential
GO:0042593 glucose homeostasis
GO:0042886 amide transport
GO:0043270 positive regulation of ion transport
GO:0044070 regulation of anion transport
GO:0044283 small molecule biosynthetic process
GO:0045852 pH elevation
GO:0045921 positive regulation of exocytosis
GO:0046165 alcohol biosynthetic process
GO:0046683 response to organophosphorus
GO:0046879 hormone secretion
GO:0046883 regulation of hormone secretion
GO:0046887 positive regulation of hormone secretion
GO:0048232 male gamete generation
GO:0048240 sperm capacitation
GO:0048278 vesicle docking
GO:0048469 cell maturation
GO:0048515 spermatid differentiation
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050796 regulation of insulin secretion
GO:0051047 positive regulation of secretion
GO:0051222 positive regulation of protein transport
GO:0051453 regulation of intracellular pH
GO:0051454 intracellular pH elevation
GO:0051591 response to cAMP
GO:0055067 monovalent inorganic cation homeostasis
GO:0060081 membrane hyperpolarization
GO:0060627 regulation of vesicle-mediated transport
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0071320 cellular response to cAMP
GO:0071322 cellular response to carbohydrate stimulus
GO:0071326 cellular response to monosaccharide stimulus
GO:0071331 cellular response to hexose stimulus
GO:0071333 cellular response to glucose stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0090087 regulation of peptide transport
GO:0090276 regulation of peptide hormone secretion
GO:0090277 positive regulation of peptide hormone secretion
GO:0098656 anion transmembrane transport
GO:0098661 inorganic anion transmembrane transport
GO:1901529 positive regulation of anion channel activity
GO:1901615 organic hydroxy compound metabolic process
GO:1901617 organic hydroxy compound biosynthetic process
GO:1902159 regulation of cyclic nucleotide-gated ion channel activity
GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity
GO:1902476 chloride transmembrane transport
GO:1902652 secondary alcohol metabolic process
GO:1902653 secondary alcohol biosynthetic process
GO:1902941 regulation of voltage-gated chloride channel activity
GO:1902943 positive regulation of voltage-gated chloride channel activity
GO:1903532 positive regulation of secretion by cell
GO:1903793 positive regulation of anion transport
GO:1903795 regulation of inorganic anion transmembrane transport
GO:1903797 positive regulation of inorganic anion transmembrane transport
GO:1903959 regulation of anion transmembrane transport
GO:1903961 positive regulation of anion transmembrane transport
GO:1904951 positive regulation of establishment of protein localization
GO:2000273 positive regulation of receptor activity
GO:2001225 regulation of chloride transport
Molecular Function GO:0005216 ion channel activity
GO:0005217 intracellular ligand-gated ion channel activity
GO:0005224 ATP-binding and phosphorylation-dependent chloride channel activity
GO:0005253 anion channel activity
GO:0005254 chloride channel activity
GO:0005260 channel-conductance-controlling ATPase activity
GO:0008200 ion channel inhibitor activity
GO:0008509 anion transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015103 inorganic anion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016247 channel regulator activity
GO:0016248 channel inhibitor activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0017081 chloride channel regulator activity
GO:0019869 chloride channel inhibitor activity
GO:0022803 passive transmembrane transporter activity
GO:0022804 active transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0022853 active ion transmembrane transporter activity
GO:0030165 PDZ domain binding
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043225 ATPase-coupled anion transmembrane transporter activity
GO:0043492 ATPase activity, coupled to movement of substances
Cellular Component GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005791 rough endoplasmic reticulum
GO:0005798 Golgi-associated vesicle
GO:0010008 endosome membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0031205 endoplasmic reticulum Sec complex
GO:0031901 early endosome membrane
GO:0034702 ion channel complex
GO:0034707 chloride channel complex
GO:0044440 endosomal part
GO:0045177 apical part of cell
GO:0055037 recycling endosome
GO:0098852 lytic vacuole membrane
GO:1902495 transmembrane transporter complex
GO:1990351 transporter complex
> KEGG and Reactome Pathway
 
KEGG hsa02010 ABC transporters
hsa04024 cAMP signaling pathway
hsa04152 AMPK signaling pathway
hsa04530 Tight junction
hsa04971 Gastric acid secretion
hsa04972 Pancreatic secretion
hsa04976 Bile secretion
Reactome R-HSA-5619084: ABC transporter disorders
R-HSA-382556: ABC-family proteins mediated transport
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828: Clathrin-mediated endocytosis
R-HSA-5678895: Defective CFTR causes cystic fibrosis
R-HSA-5688426: Deubiquitination
R-HSA-1643685: Disease
R-HSA-5619115: Disorders of transmembrane transporters
R-HSA-199991: Membrane Trafficking
R-HSA-392499: Metabolism of proteins
R-HSA-597592: Post-translational protein modification
R-HSA-195258: RHO GTPase Effectors
R-HSA-5627083: RHO GTPases regulate CFTR trafficking
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-382551: Transmembrane transport of small molecules
R-HSA-5689880: Ub-specific processing proteases
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CFTR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CFTR in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CFTR in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.0250.927
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5520.345
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.4470.346
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.3810.61
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.5140.733
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2270.885
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.7160.479
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.1180.949
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.5730.387
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.5230.368
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2070.127
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-1.110.00916
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CFTR in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277311.16.84.30.443
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275911.18.52.60.702
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211733.311.821.50.148
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8637.5037.50.209
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131130.818.212.60.649
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382718.43.714.70.126
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221322.77.7150.377
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161412.5012.50.485
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CFTR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CFTR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CFTR.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CFTR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CFTR expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CFTR and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCFTR
Namecystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Aliases ABC35; TNR-CFTR; CFTR/MRP; ATP-binding cassette sub-family C, member 7; CF; ABCC7; cystic fibrosis transmemb ......
Chromosomal Location7q31.2
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CFTR collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CFTR.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB00887BumetanideSmall MoleculeCFTR, SLC12A1, SLC12A2, SLC12A4, SLC12A55
DB01016GlyburideSmall MoleculeABCA1, ABCB11, ABCC8, ABCC9, CFTR, CPT1A, KCNJ11, KCNJ11, KCNJ5, K ......10
DB01050IbuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARA, PPARG, PTGS1, PTGS2, SLC15A1, THBD10
DB02587ColforsinSmall MoleculeADCY2, ADCY5, CFTR3
DB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall MoleculeACTA1, CCT3, CFTR, CSNK2A1, DAPK1, DTYMK, EPHA2, EPHB2, GALK1, GSK ......26
DB04522DexfosfoserineSmall MoleculeCFTR, KCNC4, PDPK1, PIM1, PRKACA, PRKCQ, PYGL, PYGM, REG1A, RHO, S ......13
DB04941CrofelemerSmall MoleculeANO1, CFTR2
DB06266LonidamineSmall MoleculeCFTR, HK12
DB08820IvacaftorSmall MoleculeCFTR1
DB09213DexibuprofenSmall MoleculeBCL2, CFTR, FABP2, PLAT, PPARG, PTGS1, PTGS2, THBD8
DB09280LumacaftorSmall MoleculeCFTR1
DB11712TezacaftorSmall MoleculeCFTR1