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Browse CD81

Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Basolateral cell membrane Multi-pass membrane protein Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane.
Domain PF00335 Tetraspanin family
Function

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.; FUNCTION: (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.

> Gene Ontology
 
Biological Process GO:0000187 activation of MAPK activity
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0006644 phospholipid metabolic process
GO:0006898 receptor-mediated endocytosis
GO:0007039 protein catabolic process in the vacuole
GO:0009894 regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
GO:0019216 regulation of lipid metabolic process
GO:0030260 entry into host cell
GO:0030888 regulation of B cell proliferation
GO:0030890 positive regulation of B cell proliferation
GO:0031329 regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031623 receptor internalization
GO:0031647 regulation of protein stability
GO:0032147 activation of protein kinase activity
GO:0032943 mononuclear cell proliferation
GO:0032944 regulation of mononuclear cell proliferation
GO:0032946 positive regulation of mononuclear cell proliferation
GO:0033674 positive regulation of kinase activity
GO:0042100 B cell proliferation
GO:0042113 B cell activation
GO:0042176 regulation of protein catabolic process
GO:0043112 receptor metabolic process
GO:0043126 regulation of 1-phosphatidylinositol 4-kinase activity
GO:0043128 positive regulation of 1-phosphatidylinositol 4-kinase activity
GO:0043405 regulation of MAP kinase activity
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043550 regulation of lipid kinase activity
GO:0044406 adhesion of symbiont to host
GO:0044409 entry into host
GO:0044650 adhesion of symbiont to host cell
GO:0045732 positive regulation of protein catabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0046651 lymphocyte proliferation
GO:0046718 viral entry into host cell
GO:0046813 receptor-mediated virion attachment to host cell
GO:0050670 regulation of lymphocyte proliferation
GO:0050671 positive regulation of lymphocyte proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050864 regulation of B cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050871 positive regulation of B cell activation
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051701 interaction with host
GO:0051806 entry into cell of other organism involved in symbiotic interaction
GO:0051828 entry into other organism involved in symbiotic interaction
GO:0055094 response to lipoprotein particle
GO:0055098 response to low-density lipoprotein particle
GO:0061462 protein localization to lysosome
GO:0070661 leukocyte proliferation
GO:0070663 regulation of leukocyte proliferation
GO:0070665 positive regulation of leukocyte proliferation
GO:0071402 cellular response to lipoprotein particle stimulus
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072665 protein localization to vacuole
GO:0090218 positive regulation of lipid kinase activity
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903725 regulation of phospholipid metabolic process
GO:1903727 positive regulation of phospholipid metabolic process
GO:1904350 regulation of protein catabolic process in the vacuole
GO:1904352 positive regulation of protein catabolic process in the vacuole
Molecular Function GO:0003823 antigen binding
GO:0023023 MHC protein complex binding
GO:0023026 MHC class II protein complex binding
GO:1990459 transferrin receptor binding
Cellular Component GO:0001772 immunological synapse
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
> KEGG and Reactome Pathway
 
KEGG hsa04662 B cell receptor signaling pathway
Reactome R-HSA-1280218: Adaptive Immune System
R-HSA-168256: Immune System
R-HSA-198933: Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CD81 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CD81 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26329536Breast Carcinoma; Lung CarcinomaInhibit immunity (T cell function)Tetraspanin CD81 Promotes Tumor Growth and Metastasis by Modulating the Functions of T Regulatory and Myeloid-Derived Suppressor Cells
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CD81 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CD81 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0120.973
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.4610.913
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3110.922
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0770.874
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.3940.876
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.6680.829
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0290.957
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.140.954
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0030.999
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.9090.759
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2790.78
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1570.0506
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD81. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD81. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD81.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD81. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CD81 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CD81 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCD81
NameCD81 molecule
Aliases TAPA-1; TSPAN28; TAPA1; CD81 antigen (target of antiproliferative antibody 1); CVID6; S5.7; 26 kDa cell surf ......
Chromosomal Location11p15.5
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CD81 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.