[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse CD1E

Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location T-cell surface glycoprotein CD1e, membrane-associated: Golgi apparatus membrane; Single-pass type I membrane protein. Early endosome. Late endosome. Note=Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.; SUBCELLULAR LOCATION: T-cell surface glycoprotein CD1e, soluble: Lysosome lumen.
Domain PF07654 Immunoglobulin C1-set domain
PF16497 MHC-I family domain
Function

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

> Gene Ontology
 
Biological Process GO:0002250 adaptive immune response
GO:0002475 antigen processing and presentation via MHC class Ib
GO:0019882 antigen processing and presentation
GO:0019884 antigen processing and presentation of exogenous antigen
GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
Molecular Function GO:0003823 antigen binding
GO:0030881 beta-2-microglobulin binding
GO:0030882 lipid antigen binding
GO:0030883 endogenous lipid antigen binding
GO:0030884 exogenous lipid antigen binding
GO:0033218 amide binding
GO:0042277 peptide binding
GO:0071723 lipopeptide binding
Cellular Component GO:0005769 early endosome
GO:0005770 late endosome
GO:0005775 vacuolar lumen
GO:0043202 lysosomal lumen
> KEGG and Reactome Pathway
 
KEGG hsa04530 Tight junction
hsa04640 Hematopoietic cell lineage
Reactome -
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CD1E and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CD1E in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CD1E in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.3890.26
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.2350.679
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.5120.3
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.6440.372
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.0880.94
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.5760.217
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.4080.616
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2490.303
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.5460.669
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 481.1610.185
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 282.4460.0239
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7290.00972
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CD1E in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277322.25.516.70.0222
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275922.26.815.40.0651
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.85.9-1.11
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.79.1-1.41
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916012.5-12.50.52
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221313.6013.60.279
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CD1E. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CD1E. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CD1E.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CD1E. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CD1E expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CD1E and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCD1E
NameCD1e molecule
Aliases CD1E antigen, e polypeptide; CD1e antigen; R2G1; hCD1e; leukocyte differentiation antigen; thymocyte antigen ......
Chromosomal Location1q23.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CD1E collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.