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Browse CGA

Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00236 Glycoprotein hormone
Function

-

> Gene Ontology
 
Biological Process GO:0010817 regulation of hormone levels
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0030335 positive regulation of cell migration
GO:0040017 positive regulation of locomotion
GO:0042445 hormone metabolic process
GO:0051272 positive regulation of cellular component movement
GO:0051604 protein maturation
GO:2000147 positive regulation of cell motility
Molecular Function GO:0005179 hormone activity
Cellular Component GO:0005796 Golgi lumen
> KEGG and Reactome Pathway
 
KEGG hsa04080 Neuroactive ligand-receptor interaction
hsa04912 GnRH signaling pathway
hsa04913 Ovarian steroidogenesis
hsa04917 Prolactin signaling pathway
hsa04918 Thyroid hormone synthesis
Reactome R-HSA-209776: Amine-derived hormones
R-HSA-193048: Androgen biosynthesis
R-HSA-446203: Asparagine N-linked glycosylation
R-HSA-373076: Class A/1 (Rhodopsin-like receptors)
R-HSA-418555: G alpha (s) signalling events
R-HSA-388396: GPCR downstream signaling
R-HSA-500792: GPCR ligand binding
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-209822: Glycoprotein hormones
R-HSA-375281: Hormone ligand-binding receptors
R-HSA-1430728: Metabolism
R-HSA-71291: Metabolism of amino acids and derivatives
R-HSA-556833: Metabolism of lipids and lipoproteins
R-HSA-392499: Metabolism of proteins
R-HSA-196071: Metabolism of steroid hormones
R-HSA-193993: Mineralocorticoid biosynthesis
R-HSA-975576: N-glycan antennae elongation in the medial/trans-Golgi
R-HSA-209952: Peptide hormone biosynthesis
R-HSA-2980736: Peptide hormone metabolism
R-HSA-597592: Post-translational protein modification
R-HSA-975578: Reactions specific to the complex N-glycan synthesis pathway
R-HSA-162582: Signal Transduction
R-HSA-372790: Signaling by GPCR
R-HSA-209943: Steroid hormones
R-HSA-8866910: TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-209968: Thyroxine biosynthesis
R-HSA-8864260: Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
R-HSA-948021: Transport to the Golgi and subsequent modification
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CGA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CGA and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
27435394Ovarian CarcinomaPromote immunityFSHR is expressed in gynecologic malignancies of different histologic types but not in nonovarian healthy tissues. T cells redirected against FSHR+ tumor cells with full-length FSH represent a promising therapeutic alternative against a broad range of ovarian malignancies, with negligible toxicity even in the presence of cognate targets in tumor-free ovaries.
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CGA in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CGA in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)141201
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)8701
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-1.5090.124
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.9010.184
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-1.0360.604
729033130MelanomaallAnti-PD-1 (nivolumab) 262301
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 111201
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 4801
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 2801
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0550.864
> Mutation difference between responders and non-responders
 

There is no record.
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CGA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CGA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CGA.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CGA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CGA expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CGA and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCGA
Nameglycoprotein hormones, alpha polypeptide
Aliases GPHa; GPHA1; FSHA; LHA; TSHA; follicle-stimulating hormone alpha subunit; chorionic gonadotropin, alpha poly ......
Chromosomal Location6q14.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CGA collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.