[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Browse CASP8

Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF01335 Death effector domain
Function

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

> Gene Ontology
 
Biological Process GO:0001701 in utero embryonic development
GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001959 regulation of cytokine-mediated signaling pathway
GO:0002218 activation of innate immune response
GO:0002221 pattern recognition receptor signaling pathway
GO:0002224 toll-like receptor signaling pathway
GO:0002237 response to molecule of bacterial origin
GO:0002521 leukocyte differentiation
GO:0002573 myeloid leukocyte differentiation
GO:0002753 cytoplasmic pattern recognition receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0002757 immune response-activating signal transduction
GO:0002758 innate immune response-activating signal transduction
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002763 positive regulation of myeloid leukocyte differentiation
GO:0002764 immune response-regulating signaling pathway
GO:0006839 mitochondrial transport
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0007006 mitochondrial membrane organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
GO:0008637 apoptotic mitochondrial changes
GO:0009266 response to temperature stimulus
GO:0009409 response to cold
GO:0009612 response to mechanical stimulus
GO:0010035 response to inorganic substance
GO:0010038 response to metal ion
GO:0010466 negative regulation of peptidase activity
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway
GO:0010821 regulation of mitochondrion organization
GO:0010822 positive regulation of mitochondrion organization
GO:0010939 regulation of necrotic cell death
GO:0010950 positive regulation of endopeptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0010952 positive regulation of peptidase activity
GO:0016485 protein processing
GO:0019048 modulation by virus of host morphology or physiology
GO:0019050 suppression by virus of host apoptotic process
GO:0019054 modulation by virus of host process
GO:0030099 myeloid cell differentiation
GO:0030101 natural killer cell activation
GO:0030225 macrophage differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031349 positive regulation of defense response
GO:0031638 zymogen activation
GO:0032025 response to cobalt ion
GO:0032355 response to estradiol
GO:0032496 response to lipopolysaccharide
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033668 negative regulation by symbiont of host apoptotic process
GO:0034612 response to tumor necrosis factor
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035794 positive regulation of mitochondrial membrane permeability
GO:0035821 modification of morphology or physiology of other organism
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0036462 TRAIL-activated apoptotic signaling pathway
GO:0039506 modulation by virus of host molecular function
GO:0039507 suppression by virus of host molecular function
GO:0039513 suppression by virus of host catalytic activity
GO:0039516 modulation by virus of host catalytic activity
GO:0039526 modulation by virus of host apoptotic process
GO:0039650 suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044003 modification by symbiont of host morphology or physiology
GO:0044068 modulation by symbiont of host cellular process
GO:0044359 modulation of molecular function in other organism
GO:0044362 negative regulation of molecular function in other organism
GO:0044531 modulation of programmed cell death in other organism
GO:0044532 modulation of apoptotic process in other organism
GO:0045088 regulation of innate immune response
GO:0045089 positive regulation of innate immune response
GO:0045471 response to ethanol
GO:0045637 regulation of myeloid cell differentiation
GO:0045639 positive regulation of myeloid cell differentiation
GO:0045649 regulation of macrophage differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0046677 response to antibiotic
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0051204 protein insertion into mitochondrial membrane
GO:0051205 protein insertion into membrane
GO:0051259 protein oligomerization
GO:0051291 protein heterooligomerization
GO:0051346 negative regulation of hydrolase activity
GO:0051604 protein maturation
GO:0051701 interaction with host
GO:0051702 interaction with symbiont
GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction
GO:0051851 modification by host of symbiont morphology or physiology
GO:0052040 modulation by symbiont of host programmed cell death
GO:0052041 negative regulation by symbiont of host programmed cell death
GO:0052053 negative regulation by symbiont of host catalytic activity
GO:0052055 modulation by symbiont of host molecular function
GO:0052056 negative regulation by symbiont of host molecular function
GO:0052148 modulation by symbiont of host catalytic activity
GO:0052150 modulation by symbiont of host apoptotic process
GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction
GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction
GO:0052204 negative regulation of molecular function in other organism involved in symbiotic interaction
GO:0052205 modulation of molecular function in other organism involved in symbiotic interaction
GO:0052248 modulation of programmed cell death in other organism involved in symbiotic interaction
GO:0052422 modulation by host of symbiont catalytic activity
GO:0052428 modification by host of symbiont molecular function
GO:0052433 modulation by organism of apoptotic process in other organism involved in symbiotic interaction
GO:0052490 negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060711 labyrinthine layer development
GO:0060715 syncytiotrophoblast cell differentiation involved in labyrinthine layer development
GO:0060759 regulation of response to cytokine stimulus
GO:0061458 reproductive system development
GO:0070265 necrotic cell death
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070585 protein localization to mitochondrion
GO:0071214 cellular response to abiotic stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0071356 cellular response to tumor necrosis factor
GO:0071407 cellular response to organic cyclic compound
GO:0071496 cellular response to external stimulus
GO:0071550 death-inducing signaling complex assembly
GO:0071593 lymphocyte aggregation
GO:0072655 establishment of protein localization to mitochondrion
GO:0072657 protein localization to membrane
GO:0090150 establishment of protein localization to membrane
GO:0090559 regulation of membrane permeability
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0097202 activation of cysteine-type endopeptidase activity
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:0097305 response to alcohol
GO:0097345 mitochondrial outer membrane permeabilization
GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:1901028 regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902041 regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902105 regulation of leukocyte differentiation
GO:1902107 positive regulation of leukocyte differentiation
GO:1902108 regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902532 negative regulation of intracellular signal transduction
GO:1902686 mitochondrial outer membrane permeabilization involved in programmed cell death
GO:1903706 regulation of hemopoiesis
GO:1903708 positive regulation of hemopoiesis
GO:1903747 regulation of establishment of protein localization to mitochondrion
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
GO:1903829 positive regulation of cellular protein localization
GO:1904951 positive regulation of establishment of protein localization
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001235 positive regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001267 regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Molecular Function GO:0004175 endopeptidase activity
GO:0004197 cysteine-type endopeptidase activity
GO:0005123 death receptor binding
GO:0005126 cytokine receptor binding
GO:0005164 tumor necrosis factor receptor binding
GO:0008234 cysteine-type peptidase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032813 tumor necrosis factor receptor superfamily binding
GO:0035877 death effector domain binding
GO:0044389 ubiquitin-like protein ligase binding
GO:0097110 scaffold protein binding
GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process
GO:0097199 cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component GO:0005741 mitochondrial outer membrane
GO:0019867 outer membrane
GO:0031264 death-inducing signaling complex
GO:0031265 CD95 death-inducing signaling complex
GO:0031968 organelle outer membrane
GO:0044297 cell body
GO:0044445 cytosolic part
GO:0045121 membrane raft
GO:0097342 ripoptosome
GO:0098589 membrane region
GO:0098857 membrane microdomain
> KEGG and Reactome Pathway
 
KEGG hsa04115 p53 signaling pathway
hsa04210 Apoptosis
hsa04620 Toll-like receptor signaling pathway
hsa04621 NOD-like receptor signaling pathway
hsa04622 RIG-I-like receptor signaling pathway
hsa04668 TNF signaling pathway
Reactome R-HSA-166054: Activated TLR4 signalling
R-HSA-75108: Activation, myristolyation of BID and translocation to mitochondria
R-HSA-109581: Apoptosis
R-HSA-111465: Apoptotic cleavage of cellular proteins
R-HSA-75153: Apoptotic execution phase
R-HSA-5621481: C-type lectin receptors (CLRs)
R-HSA-5218900: CASP8 activity is inhibited
R-HSA-5607764: CLEC7A (Dectin-1) signaling
R-HSA-5660668: CLEC7A/inflammasome pathway
R-HSA-5357769: Caspase activation via extrinsic apoptotic signalling pathway
R-HSA-264870: Caspase-mediated cleavage of cytoskeletal proteins
R-HSA-73887: Death Receptor Signalling
R-HSA-69416: Dimerization of procaspase-8
R-HSA-75157: FasL/ CD95L signaling
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-140534: Ligand-dependent caspase activation
R-HSA-166166: MyD88-independent TLR3/TLR4 cascade
R-HSA-933543: NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
R-HSA-168638: NOD1/2 Signaling Pathway
R-HSA-168643: Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
R-HSA-5357801: Programmed Cell Death
R-HSA-168928: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
R-HSA-5213460: RIPK1-mediated regulated necrosis
R-HSA-5218859: Regulated Necrosis
R-HSA-3371378: Regulation by c-FLIP
R-HSA-5357905: Regulation of TNFR1 signaling
R-HSA-5675482: Regulation of necroptotic cell death
R-HSA-162582: Signal Transduction
R-HSA-75893: TNF signaling
R-HSA-5357786: TNFR1-induced proapoptotic signaling
R-HSA-75158: TRAIL signaling
R-HSA-937061: TRIF-mediated TLR3/TLR4 signaling
R-HSA-2562578: TRIF-mediated programmed cell death
R-HSA-168164: Toll Like Receptor 3 (TLR3) Cascade
R-HSA-166016: Toll Like Receptor 4 (TLR4) Cascade
R-HSA-168898: Toll-Like Receptors Cascades
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CASP8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between CASP8 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
25600646Hepatocellular CarcinomaInhibit immunity (T cell function)TLR2 limits development of hepatocellular carcinoma by reducing IL18-mediated immunosuppression. IL18 production was mediated by caspase-8 insofar as the decrease in its silencing was sufficient to attenuate levels of mature IL18 in Tlr2(-/-) mice.
21282461Bladder CarcinomaPromote immunityWe demonstrate that receptor-interacting protein 1 (RIP1) is an integral component of this complex and is required for CD40 ligand-induced caspase-8 activation and tumor cell killing.
17450141Lung Carcinoma; Esophageal Carcinoma; Gastric Carcinoma; Colorectal Carcinoma; Cervical Carcinoma; Breast CarcinomaInhibit immunity (T cell function)Using a haplotype-tagging SNP approach, we identified a six-nucleotide deletion (-652 6N del) variant in the CASP8 promoter associated with decreased risk of lung cancer. The deletion destroys a stimulatory protein 1 binding site and decreases CASP8 transcription. Biochemical analyses showed that T lymphocytes with the deletion variant had lower caspase-8 activity and activation-induced cell death upon stimulation with cancer cell antigens. Case-control analyses of 4,995 individuals with cancer and 4,972 controls in a Chinese population showed that this genetic variant is associated with reduced susceptibility to multiple cancers, including lung, esophageal, gastric, colorectal, cervical and breast cancers, acting in an allele dose-dependent manner.
17200356Ewing SarcomaPromote immunity (T cell function)Although all tested Ewing sarcoma cell lines expressed cFLIP, resistance to CD95/Fas-mediated apoptosis was only observed in two cell lines lacking caspase-8 expression.
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CASP8 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR Second most enriched score: 0.82 Sensitive to T cell-mediated killing
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CASP8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1860.535
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0030.998
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3340.74
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1660.525
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.4370.796
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.1770.934
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0010.998
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.2490.858
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.230.886
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7030.63
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4650.511
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.140.0616
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CASP8 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59200200.357
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38275.305.30.507
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASP8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASP8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASP8.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASP8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CASP8 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CASP8 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCASP8
Namecaspase 8, apoptosis-related cysteine peptidase
Aliases MCH5; MACH; FLICE; Casp-8; caspase 8, apoptosis-related cysteine protease; ALPS2B; CAP4; FADD-homologous ICE ......
Chromosomal Location2q33-q34
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CASP8 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CASP8.
ID Name Drug Type Targets #Targets
DB12651BardoxoloneSmall MoleculeCASP81