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Browse CASK

Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Cytoplasm Cell membrane Peripheral membrane protein
Domain PF00625 Guanylate kinase
PF02828 L27 domain
PF00595 PDZ domain (Also known as DHR or GLGF)
PF00069 Protein kinase domain
PF07653 Variant SH3 domain
Function

Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.

> Gene Ontology
 
Biological Process GO:0001505 regulation of neurotransmitter levels
GO:0001952 regulation of cell-matrix adhesion
GO:0001953 negative regulation of cell-matrix adhesion
GO:0006816 calcium ion transport
GO:0006836 neurotransmitter transport
GO:0007160 cell-matrix adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007269 neurotransmitter secretion
GO:0009116 nucleoside metabolic process
GO:0009119 ribonucleoside metabolic process
GO:0009123 nucleoside monophosphate metabolic process
GO:0009126 purine nucleoside monophosphate metabolic process
GO:0009132 nucleoside diphosphate metabolic process
GO:0009135 purine nucleoside diphosphate metabolic process
GO:0009150 purine ribonucleotide metabolic process
GO:0009161 ribonucleoside monophosphate metabolic process
GO:0009167 purine ribonucleoside monophosphate metabolic process
GO:0009179 purine ribonucleoside diphosphate metabolic process
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0010837 regulation of keratinocyte proliferation
GO:0010839 negative regulation of keratinocyte proliferation
GO:0010959 regulation of metal ion transport
GO:0023061 signal release
GO:0031589 cell-substrate adhesion
GO:0032102 negative regulation of response to external stimulus
GO:0042278 purine nucleoside metabolic process
GO:0043270 positive regulation of ion transport
GO:0043616 keratinocyte proliferation
GO:0046037 GMP metabolic process
GO:0046128 purine ribonucleoside metabolic process
GO:0046710 GDP metabolic process
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0061041 regulation of wound healing
GO:0061045 negative regulation of wound healing
GO:0070509 calcium ion import
GO:0070838 divalent metal ion transport
GO:0072511 divalent inorganic cation transport
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0099531 presynaptic process involved in chemical synaptic transmission
GO:0099643 signal release from synapse
GO:1901068 guanosine-containing compound metabolic process
GO:1901657 glycosyl compound metabolic process
GO:1903034 regulation of response to wounding
GO:1903035 negative regulation of response to wounding
Molecular Function GO:0004385 guanylate kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005516 calmodulin binding
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019201 nucleotide kinase activity
GO:0019205 nucleobase-containing compound kinase activity
GO:0042043 neurexin family protein binding
Cellular Component GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005652 nuclear lamina
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0005929 cilium
GO:0015629 actin cytoskeleton
GO:0016323 basolateral plasma membrane
GO:0016363 nuclear matrix
GO:0030055 cell-substrate junction
GO:0031253 cell projection membrane
GO:0034399 nuclear periphery
GO:0042734 presynaptic membrane
GO:0044420 extracellular matrix component
GO:0044441 ciliary part
GO:0060170 ciliary membrane
GO:0097060 synaptic membrane
GO:0098793 presynapse
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-1500931: Cell-Cell communication
R-HSA-212676: Dopamine Neurotransmitter Release Cycle
R-HSA-1474244: Extracellular matrix organization
R-HSA-6794361: Interactions of neurexins and neuroligins at synapses
R-HSA-373753: Nephrin interactions
R-HSA-112316: Neuronal System
R-HSA-112310: Neurotransmitter Release Cycle
R-HSA-3000171: Non-integrin membrane-ECM interactions
R-HSA-6794362: Protein-protein interactions at synapses
R-HSA-3000170: Syndecan interactions
R-HSA-112315: Transmission across Chemical Synapses
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between CASK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of CASK in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NS NA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen Total # shRNA with >= 4-fold: 1 Resistant to T-cell proliferation
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of CASK in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.1940.473
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.040.973
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.3020.711
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.2020.556
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.1750.931
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.2320.932
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.0550.875
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 151101
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.1530.926
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3520.771
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2280.459
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.130.0814
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of CASK in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)8612.5012.51
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.112.5-1.41
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of CASK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of CASK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by CASK.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of CASK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of CASK expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between CASK and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolCASK
Namecalcium/calmodulin-dependent serine protein kinase (MAGUK family)
Aliases LIN2; CAGH39; FGS4; TNRC8; trinucleotide repeat containing 8; CAMGUK; CMG; MICPCH; MRXSNA; calcium/calmoduli ......
Chromosomal LocationXp11.4
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting CASK collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting CASK.
ID Name Drug Type Targets #Targets
DB01942Formic AcidSmall MoleculeACYP2, CA2, CASK, CTBP1, CYTH2, FGF1, GGACT, GPHN, HMOX1, NOS1, PV ......12